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Gene mutations which restrict Vitamin D activation (CYP27B1) results in many health problems – March 2020

Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases

Nutrients, 12 (3) 2020 Mar 18, DOI: 10.3390/nu12030801

VitaminDWiki

CYP27B1 category listing contains the following

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
Blood Test Misses a lot (VDW 3439)

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Maria Latacz 1,2, Jadwiga Snarska 3,4, Elzbieta Kostyra 1, Ewa Fiedorowicz 1, Huub FJ Savelkoul 5, Roman Grzybowski 6,7 and Anna Cieslinska 1, anna.cieslinska at uwm.edu.p. Faculty of Biology and Biotechnology, University of Warmia and Mazury, 10-719 Olsztyn, Poland; mmlatacz at gmail.com (M.L.); elzbieta.kostyra at uwm.edu.pl (E.K.); ewa.kuzbida at uwm.edu.pl (E.F.)

: Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin's lymphoma, oral lichen planus, or multiple sclerosis.

Clipped from PDF
Although the enzyme CYP27B1 initially referred only to renal tissues, its presence has been also been determined in numerous other cells from different systems, including dendritic cells, parathyroid cells, osteoblasts, osteoclasts, keratinocyte, mammary epithelial cells, renal tubular cells, pancreatic beta cells, vascular endothelial cells, and prostate epithelial cells

Sections on
Colorectal Cancer (CRC)
Prostate Cancer
Breast Cancer
Lung Cancer
Pancreatic Cancer
Thyroid Cancer
Liver Cancer
Non-Hodgkin's Lymphoma
Multiple Sclerosis (MS)
Vitamin-D-Dependent Rickets Type 1
Oral Lichen Planus

Conclusion

The process of carcinogenesis is an extremely complex process that is influenced by numerous genetic and environmental factors. It should be noted that the largest impact of the level of 25(OH)D does not come from genetic factors, but from diet and exposure to sunlight only [154]. If there is a correlation between SNPs and a specific cancer, it can only indicate a moderate risk of disease. The greatest effect of polymorphisms was observed in the case of colon cancer. When it comes to the prostate, there was only one polymorphism rs8176345 noticed in the group of African Americans. In breast cancer, a relationship was observed at rs10877012, whereas in some cases rs4646536 contributed to the occurrence of side effects during the treatment of the pathology. The risk of smallcell lung cancer underwent modifications in the case of rs3782130. The two other polymorphisms rs10877012 and rs4646536 have an impact on the development of hepatocellular carcinoma in HCV patients. There was no evidence of dependence for pancreas, thyroid, or non-Hodgkin's lymphoma. The important role of vitamin D in the ethiopathogenesis of multiple sclerosis and vitamin-D- dependent rickets type 1 was based on CYP27B1 polymorphisms. A summary of the role of polymorphisms in CYP27B1 gene in the occurrence of diseases is provided in Table 1.

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