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Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019

Vitamin D status in pregnant women with asthma and its association with adverse respiratory outcomes during infancy.

J Matern Fetal Neonatal Med. 2019 Jun;32(11):1820-1825. doi: 10.1080/14767058.2017.1419176.

Jensen ME1, Murphy VE1, Gibson PG2,3, Mattes J1,4, Camargo CA Jr5.
1 Priority Research Centre Grow Up Well, University of Newcastle and Hunter Medical Research Institute , Newcastle , Australia.
2 Department of Respiratory and Sleep Medicine , John Hunter Hospital , Newcastle , Australia.
3 Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute , Newcastle , Australia.
4 Respiratory Department , John Hunter Children's Hospital , Newcastle , Australia.
5 Dept. of Emergency Medicine , Mass. General Hospital, Harvard Medical School , Boston , MA , USA.

BACKGROUND:
Vitamin D may influence pregnancy and infant outcomes, especially infant respiratory health. This study aimed to examine vitamin D status in pregnant women with asthma, and whether higher vitamin D levels are associated with fewer adverse respiratory outcomes in their infants.

METHODS:
Pregnant women with asthma, recruited from John Hunter Hospital Newcastle Australia (latitude 33°S), had serum total 25-hydroxyvitamin-D (25(OH)D) measured at 16 and 35 weeks gestation. Infant respiratory outcomes were collected at 12 months by parent-report questionnaire. Mother-infant dyads were grouped by serum 25(OH)D during pregnancy: 25(OH)D < 75 nmol/L (at both time-points) versus 25(OH)D ≥ 75 nmol/L (at one or both time-points).

RESULTS:
In 52 pregnant women with asthma, mean serum 25(OH)D levels were

  • 61 (range 26-110) nmol/L at 16 weeks, and
  • 65 (range 32-116) nmol/L at 35 weeks, gestation.

Thirty-one (60%) women had 25(OH)D < 75 nmol/L at both time-points; 21 (40%) had 25(OH)D ≥ 75 nmol/L at one or both time-points.
Maternal 25(OH)D < 75 nmol/L during pregnancy was associated with a higher proportion of infants with "wheeze ever" at 12 months, compared with 25(OH)D ≥ 75 nmol/L (71 versus 43%, p = .04).
Infant acute-care presentations (45% versus 13%, p = .02) and oral corticosteroid use (26 versus 4%, p = .03) due to "asthma/wheezing" were higher in the maternal group with 25(OH)D < 75 nmol/L, versus ≥75 nmol/L.

CONCLUSIONS:
Most pregnant women with asthma had low vitamin D status, which persisted across gestation. Low maternal vitamin D status was associated with greater risk of adverse respiratory outcomes in their infants, a group at high risk of developing childhood asthma.

PMID: 29303025 DOI: 10.1080/14767058.2017.1419176

Created by admin. Last Modification: Saturday June 22, 2019 16:46:46 GMT-0000 by admin. (Version 4)
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