Vitamin D status in pregnant women with asthma and its association with adverse respiratory outcomes during infancy.
J Matern Fetal Neonatal Med. 2019 Jun;32(11):1820-1825. doi: 10.1080/14767058.2017.1419176.
- Overview Asthma and Vitamin D
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
Jensen ME1, Murphy VE1, Gibson PG2,3, Mattes J1,4, Camargo CA Jr5.
1 Priority Research Centre Grow Up Well, University of Newcastle and Hunter Medical Research Institute , Newcastle , Australia.
2 Department of Respiratory and Sleep Medicine , John Hunter Hospital , Newcastle , Australia.
3 Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute , Newcastle , Australia.
4 Respiratory Department , John Hunter Children's Hospital , Newcastle , Australia.
5 Dept. of Emergency Medicine , Mass. General Hospital, Harvard Medical School , Boston , MA , USA.
Vitamin D may influence pregnancy and infant outcomes, especially infant respiratory health. This study aimed to examine vitamin D status in pregnant women with asthma, and whether higher vitamin D levels are associated with fewer adverse respiratory outcomes in their infants.
Pregnant women with asthma, recruited from John Hunter Hospital Newcastle Australia (latitude 33°S), had serum total 25-hydroxyvitamin-D (25(OH)D) measured at 16 and 35 weeks gestation. Infant respiratory outcomes were collected at 12 months by parent-report questionnaire. Mother-infant dyads were grouped by serum 25(OH)D during pregnancy: 25(OH)D < 75 nmol/L (at both time-points) versus 25(OH)D ≥ 75 nmol/L (at one or both time-points).
In 52 pregnant women with asthma, mean serum 25(OH)D levels were
- 61 (range 26-110) nmol/L at 16 weeks, and
- 65 (range 32-116) nmol/L at 35 weeks, gestation.
Thirty-one (60%) women had 25(OH)D < 75 nmol/L at both time-points; 21 (40%) had 25(OH)D ≥ 75 nmol/L at one or both time-points.
Maternal 25(OH)D < 75 nmol/L during pregnancy was associated with a higher proportion of infants with "wheeze ever" at 12 months, compared with 25(OH)D ≥ 75 nmol/L (71 versus 43%, p = .04).
Infant acute-care presentations (45% versus 13%, p = .02) and oral corticosteroid use (26 versus 4%, p = .03) due to "asthma/wheezing" were higher in the maternal group with 25(OH)D < 75 nmol/L, versus ≥75 nmol/L.
Most pregnant women with asthma had low vitamin D status, which persisted across gestation. Low maternal vitamin D status was associated with greater risk of adverse respiratory outcomes in their infants, a group at high risk of developing childhood asthma.
PMID: 29303025 DOI: 10.1080/14767058.2017.1419176