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Those with Asthma or COPD had half the response to Vitamin D – March 2020

Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease

Am J Respir Crit Care Med. 2020 Mar 18, DOI: 10.1164/rccm.201909-1867OC
David A Jolliffe 1, Christos Stefanidis 1, Zhican Wang 2, Nazanin Z Kermani 3, Vassil Dimitrov 4, John H White 5, John E McDonough 6, Wim Janssens 7, Paul Pfeffer 8, Christopher J Griffiths 9, Andrew Bush 10, Yike Guo 3, Stephanie Christenson 11, Ian M Adcock 12, Kian Fan Chung 13, Kenneth E Thummel 2, Adrian R Martineau 14


Stimulus: 120,000 IU of Vitamin D every 2 months for a year
Response: asthmatics 8 ng, COPD 9 ng, controls 16 ng

This has been seen many times: takes 2 to 3X more vitamin D to treat a disease than to prevent it
Possible reasons include

  1. The disease actually consumes Vitamin D
  2. Poor Vitamin D genes ==> both disease and need for higher doses
  3. Poor liver processing
  4. Poor gut processing

Note: #3 and #4 could be checked by by-passing the gut and liver

 Download the PDF from Sci-Hub via VitaminDWiki

Rationale: Vitamin D deficiency is common in patients with asthma and COPD. Low 25-hydroxyvitamin D (25[OH]D) levels may represent a cause or a consequence of these conditions.

Objective: To determine whether vitamin D metabolism is altered in asthma or COPD.

Methods: We conducted a longitudinal study in 186 adults to determine whether the 25(OH)D response to six oral doses of 3 mg vitamin D3, administered over one year, differed between those with asthma or COPD vs. controls. Serum concentrations of vitamin D3, 25(OH)D3 and 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3) were determined pre- and post-supplementation in 93 adults with asthma, COPD or neither condition, and metabolite-to-parent compound molar ratios were compared between groups to estimate hydroxylase activity. Additionally, we analyzed fourteen datasets to compare expression of 1α,25[OH]2D3-inducible gene expression signatures in clinical samples taken from adults with asthma or COPD vs. controls.

Measurements and main results:
The mean post-supplementation 25(OH)D increase in participants with

  • asthma (20.9 nmol/L) and
  • COPD (21.5 nmol/L) was lower than in
  • controls (39.8 nmol/L; P=0.001).

Compared with controls, patients with asthma and COPD had lower molar ratios of 25(OH)D3-to-vitamin D3 and higher molar ratios of 1α,25(OH)2D3-to-25(OH)D3 both pre- and post-supplementation (P≤0.005). Inter-group differences in 1α,25[OH]2D3-inducible gene expression signatures were modest and variable where statistically significant.

Conclusions: Attenuation of the 25(OH)D response to vitamin D supplementation in asthma and COPD associated with reduced molar ratios of 25(OH)D3-to-vitamin D3 and increased molar ratios of 1α,25(OH)2D3-to-25(OH)D3 in serum, suggesting that vitamin D metabolism is dysregulated in these conditions.

4 studies of Asthma and gut (Bifidobacterium infantis 35,624 helps - it is on Amazon)

The Role of the Microbiome in Asthma: The Gut–Lung Axis - Dec 2018
Int J Mol Sci. 2019 Jan; 20(1): 123 online 2018 Dec 30. doi: 10.3390/ijms20010123 FREE PDF
Franco Frati,1 Cristina Salvatori,1 Cristoforo Incorvaia,2 Alessandro Bellucci,1 Giuseppe Di Cara,1 Francesco Marcucci,1 and Susanna Esposito1,*

Asthma is one of the most common chronic respiratory diseases worldwide. It affects all ages but frequently begins in childhood. Initiation and exacerbations may depend on individual susceptibility, viral infections, allergen exposure, tobacco smoke exposure, and outdoor air pollution. The aim of this review was to analyze the role of the gut–lung axis in asthma development, considering all asthma phenotypes, and to evaluate whether microbe-based therapies may be used for asthma prevention. Several studies have confirmed the role of microbiota in the regulation of immune function and the development of atopy and asthma. These clinical conditions have apparent roots in an insufficiency of early life exposure to the diverse environmental microbiota necessary to ensure colonization of the gastrointestinal and/or respiratory tracts. Commensal microbes are necessary for the induction of a balanced, tolerogenic immune system. The identification of commensal bacteria in both the gastroenteric and respiratory tracts could be an innovative and important issue. In conclusion, the function of microbiota in healthy immune response is generally acknowledged, and gut dysbacteriosis might result in chronic inflammatory respiratory disorders, particularly asthma. Further investigations are needed to improve our understanding of the role of the microbiome in inflammation and its influence on important risk factors for asthma, including tobacco smoke and host genetic features.

Probiotics in Children with Asthma - July 2019
Children (Basel). 2022 Jul; 9(7): 978. doi: 10.3390/children9070978 FREE PDF
Giorgio Ciprandi1,* and Maria Angela Tosca2
Pierluigi Marzuillo, Academic Editor, Ming Lim, Academic Editor, Stefano Guarino, Academic Editor, Anna Di Sessa,

A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate airway inflammation. As a result, probiotics may prevent asthma and wheezing relapse. There is evidence that some probiotic strains may improve asthma outcomes in children. In this context, the PROPAM study provided evidence that two specific strains significantly prevented asthma exacerbations and wheezing episodes. Therefore, oral probiotics could be used as add-on asthma therapy in managing children with asthma, but the choice should be based on documented evidence.

Probiotics in asthma management: fiction or truth? - March 2023
Expert Review of Clinical Immunology Volume 19, 2023 - Issue 5 https://doi.org/10.1080/1744666X.2023.2189103 FREE PDF
Giorgio CiprandiORCID Icon,Maria Angela Tosca &Lorenzo Drago
"Very recently, Bifidobacterium infantis 35,624 has been positively tested in asthmatic adults [16]. This study provided interesting results, as evidenced that this probiotic significantly improved asthma control in the subgroup of patients with initial uncontrolled asthma."

Asthma associated with Reflux - Sept 2022

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Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
click on chart to see the study

13 Items in both categories Breathing and non-daily intervention

VitaminDWiki – COPD fought by Vitamin D - many studies contains:


Study was cited 78 times as of Jan 2024

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Created by admin. Last Modification: Thursday January 25, 2024 13:03:25 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
13663 Asthma half.jpg admin 22 Mar, 2020 27.39 Kb 812
13662 Asthma half response.pdf admin 22 Mar, 2020 1.14 Mb 612