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Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018

Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial.

Pediatr Infect Dis J. 2018 Jan 8. doi: 10.1097/INF.0000000000001890.

VitaminDWiki

It appears that they started recording statistics immediately after the trial started, rather than waiting a few months for the Vitamin D levels to achieve a good enough level to provide a benefit. If they only looked at statistics after 2 months it is suspected that the 2X benefit would become something like a 4X benefit

Items in both categories Infant/Child and Immunity are listed here:

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Reduced Fever

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   Note:Flu lasted about half as long for those with vitamin D

Reduced Wheezing

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Reduced Viral load after 2 months in those going to hospital with a fever

This does not indicate the reduced number of children who did not get a fever due to the 1200 IU of vitamin D
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Zhou J1, Du J1, Huang L2, Wang Y3, Shi Y3, Lin H2.
1 Department Of Pediatrics, The First People's Hospital Of Yongkang, China.
2 Dept Of Pediatrics, The Second Affiliated Hospital And Yuying Children's Hospital Of Wenzhou Medical U., Wenzhou, China.
3 Department Of Pediatrics, Jinhua People's Hospital, Jinhua, China.

OBJECTIVES:
This study aimed to evaluate the clinical efficacy and safety of vitamin D for preventing influenza A in 400 infants in a multicenter, randomized, open, controlled clinical trial.

METHODS:
The infants were randomized into low-dose and high-dose vitamin D groups, and serum calcium, inorganic phosphorus and 25-hydroxyvitamin D levels were detected thrice in 4 months. Infants infected with influenza A were monitored for symptoms including fever, cough, and wheezing. Pathogen levels and safety of vitamin D treatment were also evaluated.

RESULTS:
Of 121 cases in total, 78 and 43 cases of influenza A infection occurred in the low-dose and high-dose vitamin D groups, respectively. There was a significant difference between the groups (χ = 14.6324, P = 0.0001). Among the cases of influenza infection, the median durations for fever, cough, and wheezing were shorter in the high-dose vitamin D group than in the low-dose vitamin D group. The viral loads showed a downward trend in both groups, and were significantly different between the groups at the second and third detections. Additionally, the incidences of adverse events and severe adverse events were very low and not significantly different between the two groups.

CONCLUSION:
High-dose vitamin D (1200 IU) is suitable for the prevention of seasonal influenza as evidenced by rapid relief from symptoms, rapid decrease in viral loads, and disease recovery. In addition, high-dose vitamin D is probably safe for infants.

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Created by admin. Last Modification: Friday March 19, 2021 13:58:51 GMT-0000 by admin. (Version 19)
Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018        
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Attached files

ID Name Comment Uploaded Size Downloads
15279 Viral load months.jpg admin 19 Mar, 2021 13:38 33.01 Kb 55
15278 Influenza 1200 IU.pdf admin 19 Mar, 2021 13:14 486.78 Kb 58
14937 Preventive Effects of Vitamin D on Seasonal Influenza A in Infants.pdf admin 28 Jan, 2021 04:02 485.80 Kb 56
9372 Influenza -A fever.jpg admin 17 Feb, 2018 23:06 35.89 Kb 4900
9162 Influenza-A Wheezing.jpg admin 10 Jan, 2018 14:39 29.43 Kb 882
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