Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial.
Pediatr Infect Dis J. 2018 Jan 8. doi: 10.1097/INF.0000000000001890.
It appears that they started recording statistics immediately after the trial started, rather than waiting a few months for the Vitamin D levels to achieve a good enough level to provide a benefit. If they only looked at statistics after 2 months it is suspected that the 2X benefit would become something like a 4X benefit
- Overview Influenza and vitamin D
- Influenza vaccine antibodies not change with Vitamin D – 21 ng or 44 ng – RCT Feb 2019
- 7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
- Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015
- Influenza vaccine meta-analysis found moderate protection – Lancet Oct 2011 “such protection is greatly reduced or absent in some seasons” vs Vitamin D works in all seasons
- 10X reactions to flu vaccine when vitamin D deficient
- Number Needed to Treat: Flu - Vitamin D 4, Vaccination 40 – Feb 2017
- Viral infection reduced 90 percent with 2000 IU of vitamin D – Dec 2010
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
- Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017
- RSV (bronchitis and viral pneumonia) in infants associated with low vitamin D and antibiotics – Aug 2015
Items in both categories Infant/Child and Immunity are listed here:
- 2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022
- Infant and child immunity depends on Vitamin D and two Vitamin D genes – Review April 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- I have a PhD in immunology and this is how I keep my daughter from getting sick during the winter
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- Infection in first six months of life: White 69 percent, Black, 78 percent – Jan 2018
- Vitamin D does not help children (if only use 400 IU of D3 or D2 or quarterly) – Cochrane Nov 2016
- Vitamin D improves a child’s immune system – can now be claimed in Europe – Sept 2016
- Rotavirus diarrhea (nearly every child gets it) is strongly associated with low vitamin D – Aug 2015
- Immune System response of infants is associated with higher levels of vitamin D – RCT Nov 2014
- Infant sepsis strongly associated with low vitamin D – Aug 2014
- Middle ear infection (Otitis Media) and Vitamin D – many studies
- Tonsillectomy may be an indicator of low vitamin D status
- Many infant infections avoided with supplementation with 400 IU of vitamin D – Oct 2012
- TB vaccinations increased vitamin D levels a year later – Jan 2012
Note:Flu lasted about half as long for those with vitamin D
This does not indicate the reduced number of children who did not get a fever due to the 1200 IU of vitamin D
Zhou J1, Du J1, Huang L2, Wang Y3, Shi Y3, Lin H2.
1 Department Of Pediatrics, The First People's Hospital Of Yongkang, China.
2 Dept Of Pediatrics, The Second Affiliated Hospital And Yuying Children's Hospital Of Wenzhou Medical U., Wenzhou, China.
3 Department Of Pediatrics, Jinhua People's Hospital, Jinhua, China.
This study aimed to evaluate the clinical efficacy and safety of vitamin D for preventing influenza A in 400 infants in a multicenter, randomized, open, controlled clinical trial.
The infants were randomized into low-dose and high-dose vitamin D groups, and serum calcium, inorganic phosphorus and 25-hydroxyvitamin D levels were detected thrice in 4 months. Infants infected with influenza A were monitored for symptoms including fever, cough, and wheezing. Pathogen levels and safety of vitamin D treatment were also evaluated.
Of 121 cases in total, 78 and 43 cases of influenza A infection occurred in the low-dose and high-dose vitamin D groups, respectively. There was a significant difference between the groups (χ = 14.6324, P = 0.0001). Among the cases of influenza infection, the median durations for fever, cough, and wheezing were shorter in the high-dose vitamin D group than in the low-dose vitamin D group. The viral loads showed a downward trend in both groups, and were significantly different between the groups at the second and third detections. Additionally, the incidences of adverse events and severe adverse events were very low and not significantly different between the two groups.
High-dose vitamin D (1200 IU) is suitable for the prevention of seasonal influenza as evidenced by rapid relief from symptoms, rapid decrease in viral loads, and disease recovery. In addition, high-dose vitamin D is probably safe for infants.
There have actually been
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