Women who develop type 1 diabetes before age 10 die an average of nearly 18 years earlier than women who do not have diabetes, according to a study published in The Lancet. Men in the corresponding situation lose almost 14 years of life.
The lives of patients diagnosed at age 26 to 30 are shortened by an average of 10 years.
“These are disappointing and previously unknown figures,” said Araz Rawshani, MD, University of Gothenburg, Gothenburg, Sweden. “The study suggests that we must make an even greater effort to aggressively treat patients diagnosed at an early age to reduce the risk of complications and premature death.”
The research is based on extensive material from the Swedish National Diabetes Register, which has monitored 27,195 patients with type 1 diabetes for an average of 10 years. The group was compared with 135,178 controls from the general population who did not have diabetes, maintaining the same distribution regarding gender, age, and county of residence.
While researchers already knew that type 1 diabetes is associated with a lower life expectancy, until now it was unclear whether and how much gender and age at onset of illness affect both life expectancy and the risk of cardiovascular disease.
The study found that patients who developed type 1 diabetes before age 10 had hazard ratios of 4.11 for all-cause mortality, 7.38 for cardiovascular mortality, 3.96 for non-cardiovascular mortality, 11.44 for cardiovascular disease, 30.50 for coronary heart disease, 30.95 for acute myocardial infarction, 6.45 for stroke, 12.90 for heart failure, and 1.17 for atrial fibrillation.
Corresponding hazard ratios for individuals who developed type 1 diabetes at age 26 to 30 were
- 2.83 for all-cause mortality,
- 3.64 for cardiovascular mortality,
- 2.78 for non-cardiovascular mortality,
- 3.85 for cardiovascular disease,
- 6.08 for coronary heart disease,
- 5.77 for acute myocardial infarction,
- 3.22 for stroke,
- 5.07 for heart failure, and
- 1.18 for atrial fibrillation.
One of the highest increases in risk noted in the study involved myocardial infarctions in women who developed type 1 diabetes before age 10.
The risk for these women is 90 times higher than for controls without diabetes.
“The study opens up the potential for individualised care,” said Dr. Rawshani. “We know with certainty that if we maintain good blood sugar control in these patients, we can lower the risk of cardiovascular damage. This makes it important to carefully consider both evidence-based medications and modern technological aids for blood sugar measurements and insulin administration in patients diagnosed with type 1 diabetes at an early age.”
“At the same time, the study must also be viewed in the light of the tremendous progress that has been made in the past few decades,” he concluded. “Management of type 1 diabetes is nowadays highly sophisticated, with modern tools for glucose monitoring, delivery of insulin, and management of cardiovascular risk factors. Those who live with diabetes today, and those who will acquire the disease, will enjoy longer and healthier lives in the years to come.”
Pages listed in BOTH of the VitaminDWiki categories Diabetes and Infant/Child - (a proxy for Type 1)
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019
- Milk Consumption Is strong linked to Type 1 Diabetes – Dr. Greger Nov 2019
- T1 Diabetes treated by Vitamin D and Omega-3 (many other studies agree) Jan 2018
- Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019
- Type 1 diabetes trial having problems getting participants – too many taking Vitamin D or Omega-3 – Aug 2019
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- T1 Diabetes reduction by high Omega-3 and Vitamin D – GRH ongoing observation
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- T1 Diabetes – how it may be prevented and treated by Vitamin D – Dec 2018
- Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
- Type 1 Diabetes is increasing – decreased vitamin D is one of the many possible reasons – Sept 2018
- Early Type 1 Diabetes May Shorten Women’s Lives by 18 Years - Aug 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Type II Diabetes in children in India increased 4 X in 20 years – Nov 2016
- Type 1 diabetes risk not decreased if add 400 IU vitamin D while pregnant (no surprise) – Dec 2016
- Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Diabetes (Type 1) increasing 4 percent per year, now 30,000 in the UK - May 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- T1 Diabetes associated with low vitamin D - Nov 2014
- Type I Diabetes stopped increasing in Finland after Vitamin D levels were raised – July 2014
- Diabetic children often need more than 7,000 IU of vitamin D – June 2014
- T1 Diabetes 35 percent more likely if 10 degrees further from equator (less vitamin D) – June 2014
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- Type 1 diabetes 3.5X more frequent if low vitamin D - Medscape CME Dec 2012
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Like their diabetic mothers, infants had low vitamin D and were slightly diabetic – May 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- Grassroots Health New Project Launch - Type 1 Diabetes Prevention! Aug 2018
Prevent T1D with Vitamin D and Omega-3
T1 diabetes OR type1 diabetes in title 107 as of April 2018