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Recurrent Wheezing in children is associated with low Vitamin D – several studies


Late-onset wheezing 24% less likely for each 5ng higher vitamin D - Sept 2022

Prenatal and child vitamin D levels and allergy and asthma in childhood
Pediatr Res. 2022 Sep 3 doi: 10.1038/s41390-022-02256-9   Behind $35 paywall
Júlia Sangüesa 1 2 3 , Jordi Sunyer 1 2 3 , Raquel Garcia-Esteban 1 2 3 , Alicia Abellan 1 2 3 4 , Ana Esplugues 2 5 6 , Judith Garcia-Aymerich 1 2 3 , Mònica Guxens 1 2 3 7 , Amaia Irizar 2 8 9 , Jordi Júlvez 1 2 3 10 , Leire Luque-García 11 , Ana Cristina Rodríguez-Dehli 2 12 , Adonina Tardón 2 13 , Maties Torrent 2 14 , Jesús Vioque 2 15 16 , Martine Vrijheid 1 2 3 , Maribel Casas 17 18 19

Background: Early-life vitamin D deficiency may impair immune system development contributing to allergy and asthma onset. Findings from prospective studies are inconsistent.

Objective: To examine whether maternal and child vitamin D levels are associated with allergic and asthma-related symptoms throughout childhood in a Spanish birth cohort.

Methods: 25-Hydroxyvitamin D3 (25(OH)D3) levels were measured in the serum of pregnant women (N = 2525) and children (N = 803). Information on allergic and asthma-related symptoms was obtained from repeated questionnaires from 1 to 9 years.

Results: A total of 19% of mothers and 24% of children had deficient 25(OH)D3 levels (<20 ng/ml). Higher child 25(OH)D3 levels at 4 years were associated with lower odds of atopic eczema from 4 to 9 years (adjusted odds ratio = 0.90; 95% CI = 0.84-0.97 per 5 ng/ml).
Higher maternal and child 25(OH)D3 levels were associated with a lower prevalence of late-onset wheezing at the limit of statistical significance (adjusted relative risk ratio (RRRadj) = 0.86; 95% CI = 0.74-1.00 and RRRadj = 0.76; 95% CI = 0.58-1.02 per 5 ng/ml, respectively). All the remaining associations were null.

Conclusion: Child 25(OH)D3 levels at pre-school age are associated with a reduced odds of atopic eczema in later childhood and both maternal and child levels may reduce the prevalence of late-onset wheezing.

Impact: In this Spanish birth cohort, with a total of 19% of mothers and 24% of children with deficient levels of vitamin D, higher child vitamin D at 4 years of age was associated with reduced odds of atopic eczema up to 9 years. There was also some evidence that higher maternal and child vitamin D levels reduced the prevalence of late-onset wheezing. Although these findings need replication, they may imply optimal vitamin D levels at pre-school age to prevent atopic eczema.


The Role of Vitamin D Deficiency in Children With Recurrent Wheezing—Clinical Significance - June 2020

Front Pediatr. 2020; 8: 344.doi: 10.3389/fped.2020.00344
Gavriela Feketea,1,2,*† Corina I. Bocsan,3,† Luminita Aurelia Stanciu,4 Anca Dana Buzoianu,3 and Mihnea Tudor Zdrenghea1,5

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Recurrent wheezing (RW) in infancy is one of the most frequent reasons for parents to consult health care providers and creates a significant global burden. Clinical course of RW is difficult to predict, also which infants will progress to asthma, since no valid biomarkers have been established. Identification of those infants with RW who are at risk of further recurrences and/or severe acute respiratory tract infection (ARTI) could help pediatricians to improve their therapeutic decisions. Increasing research interest is focused on the extra-skeletal actions of vitamin D (VD) and the clinical impact of VD insufficiency/deficiency. As VD deficiency could be a risk factor for causing RW in children, measurement of their serum level of 25-hydroxycholecalciferol [25(OH)D] is recommended. In the case of deficiency, VD administration is recommended in age-appropriate doses for at least 6 weeks, until achievement of normal blood 25(OH)D level, followed by supplementation as long as exposure to sun is inadequate. Higher doses of VD given in an attempt to prevent asthma development appear to be of no additional benefit. In children with severe ARTI, VD level is recommended to be assess.


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VitaminDWiki pages with WHEEZING in title (13 as of Sept 2022)

This list is automatically updated

Items found: 15
Title Modified
Vitamin D levels are low during Recurrent Wheezing - Feb 2024 24 Feb, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Recurrent Wheezing in children is associated with low Vitamin D – several studies 04 Sep, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Gene which predicts wheezing is associated with low vitamin D – Oct 2019 18 Oct, 2019
Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018 06 Dec, 2018
Recurrent wheeze 2X more likely if endotoxin (on some bacteria) and low vitamin D – May 2016 15 Dec, 2017
Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015 10 May, 2016
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015 25 Aug, 2015
Children who wheezed were 2.7X more likely to have little vitamin D – April 2014 18 Apr, 2015
Vitamin D and wheeze – especially in seniors – Aug 2011 26 Apr, 2014
Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 30 Jun, 2013
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Created by admin. Last Modification: Sunday September 4, 2022 10:01:39 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
14075 Recurrent F1.jpg admin 24 Jul, 2020 83.54 Kb 387
14074 Children With Recurrent Wheezing.pdf admin 24 Jul, 2020 292.68 Kb 304