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Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021

Vitamin D and asthma occurrence in children: A systematic review and meta-analysis

Journal of Pediatric Nursing, https://doi.org/10.1016/j.pedn.2021.07.005 PDF costs $14.

VitaminDWiki

Note: 3X average reduction for trials giving
200, 200, 600, 650, 1,000, 1,000, 1,200, 2,000 IU daily   for as little as 6 weeks
   Should have given > 1,500 IU daily for at least 24 weeks

Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
click on chart to see the study

VitaminDWiki pages containing ASTHMA in title

Items found: 134
Title Modified
2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022 04 Jul, 2022
The Sun is the best remedy for Your Lungs (Infection, Asthma and COPD) - video June 2022 27 Jun, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Asthma, Fractures, Prostate Cancer, Lupus, etc associated with low Vitamin D – umbrella review Nov 2021 11 Jan, 2022
Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021 09 Aug, 2021
Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 04 Aug, 2021
Asthma reduced by Vitamin D, even for those using corticosteroids - meta-analysis 2021 03 Aug, 2021
Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019 01 Jul, 2021
Overview Asthma and Vitamin D 01 Jul, 2021
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 28 Jun, 2021
Asthma treated by monthly 100,000 IU of Vitamin D if person had very low levels – RCT Feb 2021 06 Feb, 2021
Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020 12 Dec, 2020
Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017 25 Jul, 2020
Those with Asthma or COPD had half the response to Vitamin D – March 2020 19 Mar, 2020
Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019 31 Dec, 2019
Asthma worse if lower Vitamin D – Dec 2019 10 Dec, 2019
Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 26 Nov, 2019
Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019 07 Nov, 2019
Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 23 Oct, 2019
Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014 15 Oct, 2019
Interactions of Asthma Vitamin D, Pollution and Obesity – July 2019 07 Jul, 2019
Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019 22 Jun, 2019
Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019 20 Jun, 2019
Asthma is poorly controlled if have 4 ng less Vitamin D – April 2019 25 May, 2019
Asthma supplementation by Vitamin D (any amount) reduced attacks by 25 percent – meta-analysis April 2019 11 May, 2019
Perhaps reduce asthma exacerbations with Vitamin D – April 2019 28 Apr, 2019
Not all Vitamin D levels follow the season – Asthma, Rhinitis, … – March 2019 31 Mar, 2019
Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017 12 Mar, 2019
Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019 12 Mar, 2019
Asthma 3X more likely if have Multiple Sclerosis (both have low Vitamin D) – March 2019 08 Mar, 2019
Vitamin D every 14 weeks is not often enough (asthma in this case)– Feb 2019 21 Feb, 2019
Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018 08 Jan, 2019
Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune... 145 slides- 2017 30 Dec, 2018
Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018 22 Nov, 2018
Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018 03 Nov, 2018
Asthma risk reduced by 67 percent with Vitamin D supplementation if level was initially low– meta-analysis Nov 2017 01 Aug, 2018
All asthma problems reduced after 1 year of Vitamin D – Nov 2017 10 Jul, 2018
Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune, etc – slides May 2017 02 Jul, 2018
More lung capacity (bronchial asthma, FEV1) associated with higher vitamin D – July 2013 01 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 24 Jun, 2018
Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018 24 Jun, 2018
Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018 26 Apr, 2018
Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018 02 Apr, 2018
Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018 23 Feb, 2018
Cesarean (associated with low Vitamin D) increased asthma, obesity, miscarriage and stillbirth – meta-analysis Jan 2018 26 Jan, 2018
Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010 10 Jan, 2018
Lots of sugar while pregnant doubles asthma risk – 2017 08 Dec, 2017
Decreased vitamin D in children taking asthma drugs - April 2010 18 Jul, 2017
Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 18 Jul, 2017
Acetaminophen (Tylenol) increases asthma 13 Jun, 2017

Problem
The association between serum 25-Hydroxyvitamin D (25-OHD) level and asthma occurrence in children was controversial.

Eligibility criteria
The Pubmed, Ovid Medline, Embase, Cochrane Library were systematically searched up to April 13th 2020. All the study measured the serum 25-OHD level in children, or classified the children based on the 25-OHD level into severe vitamin D deficiency, insufficient deficiency and comparing the prevalence of asthma in childhood were included in our study.

Sample
A total of 35 studies were included in our meta-analysis. Among them, 24 studies were included for analyzing the association between 25-OHD level and asthma, and 12 studies evaluated the treatment effect of vitamin D.

Results
The children with asthma (5711 participants) had significant lower 25-OHD level than children without asthma (21,561 participants) (21.7 ng/ml versus 26.5 ng/ml, SMD = −1.36, 95% = −2.40 - - 0.32, P = 0.010).
Besides, the children with asthma treated with vitamin D supplement had a significantly lower recurrence rate than the placebo group (18.4% versus 35.9%, RR = 0.35, 95%CI = 0.35–0.79, P = 0.002).

Conclusions
Children with asthma had a lower 25-OHD level than healthy children.
Vitamin D supplement could decrease the asthma recurrence rate in the follow-up years.

Implications
This study implies that lower 25-OHD may cause asthma in childhood.


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