Maternal and Newborn Vitamin D-Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes.
Diabetes Care. 2019 Apr;42(4):553-559. doi: 10.2337/dc18-2176. Epub 2019 Jan 28.
Tapia G1, Mårild K2, Dahl SR3, Lund-Blix NA2,4,5, Viken MK6, Lie BA6,7, Njølstad PR8,9, Joner G5,10, Skrivarhaug T5,10, Cohen AS11, Størdal K2,12, Stene LC2.
Items in both categories Pregnancy and Vitamin D Binding Protein:
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
T1 Diabetes proxie:
Pages listed in BOTH of the categories Diabetes and Infant/Child
- FDA drug to TREAT child Type 2 diabetes (based on 1 trial of only 50) – June 2023
- Vitamin D2 not help – again ( T1 diabetes– which has been helped by D3) – Jan 2022
- Somewhat less Type 1 Diabetes in Wales recently – perhaps more sun or more vitamin D – March 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019
- Milk Consumption Is strongly linked to Type 1 Diabetes – Dr. Greger Nov 2019
- T1 Diabetes treated by Vitamin D and Omega-3 (many other studies agree) Jan 2018
- Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019
- Type 1 diabetes trial having problems getting participants – too many taking Vitamin D or Omega-3 – Aug 2019
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- T1 Diabetes reduction by high Omega-3 and Vitamin D – GRH ongoing observation
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- T1 Diabetes – how it may be prevented and treated by Vitamin D – Dec 2018
- Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
- Type 1 Diabetes is increasing – decreased vitamin D is one of the many possible reasons – Sept 2018
- Early Type 1 Diabetes May Shorten Women’s Lives by 18 Years - Aug 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Type II Diabetes in children in India increased 4 X in 20 years – Nov 2016
- Type 1 diabetes risk not decreased if add 400 IU vitamin D while pregnant (no surprise) – Dec 2016
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Diabetes (Type 1) increasing 4 percent per year, now 30,000 in the UK - May 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- T1 Diabetes associated with low vitamin D - Nov 2014
- Type I Diabetes stopped increasing in Finland after Vitamin D levels were raised – July 2014
- Diabetic children often need more than 7,000 IU of vitamin D – June 2014
- T1 Diabetes 35 percent more likely if 10 degrees further from equator (less vitamin D) – June 2014
- Higher vitamin D at birth associated with less diabetes and obesity 35 years later – Jan 2014
- Type 1 diabetes 3.5X more frequent if low vitamin D - Medscape CME Dec 2012
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Like their diabetic mothers, infants had low vitamin D and were slightly diabetic – May 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
Download the PDF from Sci-hub via VitaminDWiki
Table 2 Association between exposures and T1D
P value shown for adjusted analysis. aOR, adjusted OR. *Adjusted for child’s HLA genotype, sex, maternal ethnicity, age, prepregnancy BMI, caesarean section, and smoking. †Using maternal (midpregnancy and postpartum) samples in a mixed model to predict maternal DBP values at gestational week 36. Owing to the reduction of the sampling variation in prediction of maternal DBP, the predicted values have a lower SD of 0.35 (while, e.g., DBP in the postpartum samples has an SD of 1.52). This results in a greater observed estimate, as an increase per unit is roughly equivalent to 3 SD in this analysis. We used bootstrapping (10,000 replications) to obtain unbiased CIs and present bias-corrected CIs. ‡As these results arise from bootstrapping estimations,a P value is not provided. §There was a statistically significant interaction (Pinteraction = 0.01) between rs11568820 and 25(OH)D (Supplementary Table 3).
OBJECTIVE:
Circumstantial evidence links 25-hydroxy vitamin D [25(OH)D], vitamin D-binding protein (DBP), vitamin D-associated genes, and type 1 diabetes (T1D), but no studies have jointly analyzed these. We aimed to investigate whether DBP levels during pregnancy or at birth were associated with offspring T1D and whether vitamin D pathway genetic variants modified associations between DBP, 25(OH)D, and T1D.
RESEARCH DESIGN AND METHODS:
From a cohort of >100,000 mother/child pairs, we analyzed 189 pairs where the child later developed T1D and 576 random control pairs. We measured 25(OH)D using liquid chromatography-tandem mass spectrometry, and DBP using polyclonal radioimmunoassay, in cord blood and maternal plasma samples collected at delivery and midpregnancy. We genotyped mother and child for variants in or near genes involved in vitamin D metabolism (GC, DHCR7, CYP2R1, CYP24A1, CYP27B1, and VDR). Logistic regression was used to estimate odds ratios (ORs) adjusted for potential confounders.
RESULTS:
Higher maternal DBP levels at delivery, but not in other samples, were associated with lower offspring T1D risk (OR 0.86 [95% CI 0.74-0.98] per μmol/L increase). Higher cord blood 25(OH)D levels were associated with lower T1D risk (OR = 0.87 [95% CI 0.77-0.98] per 10 nmol/L increase) in children carrying the VDR rs11568820 G/G genotype (P interaction = 0.01 between 25(OH)D level and rs11568820). We did not detect other gene-environment interactions.
CONCLUSIONS:
Higher maternal DBP level at delivery may decrease offspring T1D risk. Increased 25(OH)D levels at birth may decrease T1D risk, depending on VDR genotype. These findings should be replicated in other studies. Future studies of vitamin D and T1D should include VDR genotype and DBP levels.