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Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022

Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function

J Allergy Clin Immunol . 2022 Nov 15;S0091-6749(22)01512-3. doi: 10.1016/j.jaci.2022.10.030 publisher charges $36 for the pdf
Hanna M Knihtilä 1 , Mengna Huang 2 , Nicole Prince 2 , Benjamin J Stubbs 2 , Vincent J Carey 2 , Nancy Laranjo 2 , Hooman Mirzakhani 2 , Robert S Zeiger 3 , Leonard B Bacharier 4 , George T O'Connor 5 , Augusto A Litonjua 6 , Scott T Weiss 2 , Jessica Lasky-Su 7

Background: Prior studies suggest that vitamin D may modify the effects of environmental exposures, however, none have investigated gestational vitamin D and cumulative tobacco smoke exposure (TSE) throughout pregnancy and early life.

Objective: We investigated the effects of early life TSE on child lung function and the modulatory effects of gestational vitamin D on this association.

Methods: The Vitamin D Antenatal Asthma Reduction Trial recruited nonsmoking pregnant women and followed the mother-child pairs to age 6 years. TSE was assessed with questionnaires and plasma cotinine measurements in the mothers (10-18 and 32-38 gestational weeks) and children (1, 3, and 6 years). Cumulative TSE was calculated from the repeated cotinine measurements. 25-hydroxyvitamin D (25[OH]D) levels were measured at 10-18 and 32-38 gestational weeks. Lung function was assessed at 6 years with spirometry and impulse oscillometry.

Results: Of the 476 mother-child pairs, 205 (43%) had increased cotinine levels at ≥1 time point. Cumulative TSE was associated with decreased FEV1 (β -0.043 L, P=0.018) and increased respiratory resistance (R5; β 0.060 kPa/L/s, P=0.002). This association persisted in subjects with insufficient (<30 ng/ml) 25(OH)D levels throughout pregnancy (β 0.077 kPa/L/s, P=0.016 for R5) but not among those with sufficient levels throughout pregnancy.

Conclusion: Cumulative TSE from pregnancy to childhood is associated with dose- and duration-dependent decreases in child lung function at 6 years even in the absence of reported maternal smoking. Gestational vitamin D may modulate this effect and have therapeutic potential for minimizing the adverse effect of TSE on lung throughout early life.

VitaminDWiki - 35 studies in both categories Pregnancy and Breathing

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See also: Smoking reduces vitamin D - many studies

See also: Overview Asthma and Vitamin D

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