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COVID appears to be treated by many antioxidants (Vitamins D, C, E, K, and Quercetin, Curcumin, etc) – Jan 2023

An emerging natural antioxidant therapy for COVID-19 infection patients: Current and future directions

FoodFrontiers. 2023;1-28. DOI: 10.1002/fft2.207
Amit Kumar Shrivastava1 I Prafulla Kumar Sahu2 I Teresa Cecchi3 I Laxmi Shrestha1 I Sanjay Kumar Shah4 I Anamika Gupta5 I Anjan Palikhey1© Bishal Joshi6 I Pramodkumar P. Gupta7 I Jitendra Upadhyaya8 I
Mahendra Paudel9 I Dr Niranjan Koirala10

  • 1 Department of Pharmacology, Universal College of Medical Sciences Bhairahawa, Rupandehi, Nepal Email:; sr.akshri.ucms.np at gmail.com
  • 2School of Pharmacy, Centurion University of Technology and Management, Bhubaneswar, Odisha, India
  • 3Chemistry Department, ITT MONTANI, Fermo, Italy
  • 4Department of Reproductive Medicine, Joint Inter-national Research Laboratory of Reproduction and Development, Chongquing Medical University, Chongqing, People's Republic of China
  • 5Sharjah Institute for Medical Sciences, University of Sharjah, Sharjah, United Arab Emirates Email: malaparab at gmail.com
  • 6Department of Physiology, Universal College of Medical Sciences Bhairahawa, Rupandehi, Nepal
  • 7School of Biotechnology and Bioinformatics, D. Y. Patil Deemed to be University, CBD Belapur, Navi Mumbai, India

Correspondence: Niranjan Koirala, Gandaki Province Academy of Science and Technology, Gandaki Province, Pokhara, Nepal. Email: koiralaresearchfoundation at gmail.com

PDF Table of Contents
Objective: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) affects millions of people worldwide. The article aims to review the therapeutic perspective on natural antioxidants, their mechanism of action, pharmacokinetics in management and cure of COVID-19/ SARS-CoV-2 infection.

Methods: We conducted a literature search including World Health Organization and National Institute of Health guidelines and clinical trials registered with ClinicalTri- als.gov limited to antioxidants in COVID-19 management.
Results: Elderly, immunocompromised patients, and others with underlying health conditions or multiple comorbidities have a high mortality rate. Disrupted redox homeostasis and oxidative stress seem to be biological pathways that may increase personal vulnerability to infection. Antioxidants like vitamins C, D, E, epigallocatechin-3 gallate, and morin have been reported to protect against COVID-19 disease. Reactive oxygen species are immunological regulatory elements of viral replication. Natural antioxidants exhibit potential action in preventing inflammation and organ dysfunction during viral infection. They also increase glutathione level, oxygenation rate, and immunological responses in the treatment of sepsis and acute respiratory distress syndrome.

Conclusion: No wonder the selection of prevention, treatment, and cure of COVID- 19 and SARS-CoV-2 mainly depends upon the antiviral and immunoregulatory activity which they possess. Yet, their efficacy against COVID-19 is of great concern and demands extensive study.
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VitaminDWiki - Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023

November 2022 https://c19early.org/

Comment by Chambers: all those under $165 are also anti-oxidants

VitaminDWiki - COVID fought by the antioxidants: Vitamin D, Zinc, Vitamin C, and Selenium – Review Sept 2022

Antioxidants and Long Covid - Nov 2022 preprint

Open Access Library Journal, 2022, Volume 9
Patrick Chambers, MD Dept of Pathology, Torrance Memorial Medical Center

Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(fibromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all portend a “long haul” with an antioxidant shortfall and elevated Ca:Mg.

Oxidative stress is the root cause. Linkage between TGF(transforming growth factor)-β, IFN(interferon)-γ, the RAS(renin angiotensin system), and the KKS(kallikrein kinin system) is discussed. Technical explanations for the renin aldosterone paradox in POTS, the betrayal of TGF-β, and the commonality of markers for the Warburg effect are offered. The etiology of the common Long Covid symptoms of post exertional malaise, fatigue, and brain fog as well as anosmia, hair loss, and GI symptoms is technically discussed. Ca:Mg is critical to the glutamate/GABA(gamma amino butyric acid) balance. The role of GABA and butyrates from the “good” intestinal bacteria in the gut-brain axis and its correlation with chronic fatigue diseases are explored. The crosstalk between the ENS(enteric nervous system) and the ANS(autonomic nervous system) and the role of the vagus in both are emphasized. HRV(heart rate variability), the fifth vital sign, points to an expanded gut-brain-heart/lung axis. A suggested approach to all of these - Long Covid, chronic fatigue diseases, post viral fatigue syndrome, and general health - is presented.
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Wonder why the study on this page did not include the antioxidants of Zinc, Magnesium, Selenium etc?

Note: Quercetin, Curcumin also get more Vitamin D to cells (increase activation of Vitamin D Receptor)

VitaminDWiki - 25 studies in both categories Virus and Magnesium

This list is automatically updated

VitaminDWiki Virus pages with ZINC in title (23 as of Sept 2022)

This list is automatically updated

Items found: 26
Title Modified
COVID was associated with low Vitamin D or Zinc – umbrella review Feb 2023 16 Feb, 2023
COVID and Zinc - many studies 12 Feb, 2023
COVID fought by the antioxidants: Vitamin D, Zinc, Vitamin C, and Selenium – Review Sept 2022 14 Sep, 2022
COVID-19 risk reduced 4X by each of: Vitamin D, Omega-3, Curcumin, Zinc (each increases D in cells) 13 Apr, 2022
Vitamin D, Zinc, Magnesium etc. are needed to fight COVID – April 2022 09 Apr, 2022
How vitamins D, C, Zinc, and Selenium might fight COVID - Dec 2021 30 Jan, 2022
Micronutrients for COVID-19: Vitamin D, Vitamin C, Melatonin, Zinc, Se, etc. - Dec 2020 02 Jan, 2022
Florida A.G. recommends Vitamin D, Zinc, Quercetin, etc. to reduce risk of COVID - Dec 12, 2021 13 Dec, 2021
COVID-19 patients had low levels of Zinc, Vitamin A, Vitamin D, and Vitamin C – Sept 2021 27 Sep, 2021
Observations that Vitamin D, Zinc, and Selenium separately reduce COVID-19 – Aug 7, 2020 16 Sep, 2021
Vitamin D, C, A, and E, as well as Iron, Se, and Zinc each augment vaccine response – July 2021 20 Jul, 2021
COVID-19 risks reduced by Vitamin D, Magnesium, Zinc, Resveratrol, Omega-3, etc. (auto-updated) 19 Jul, 2021
How Vitamin D, Magnesium, Omega-3 and Zinc prevent and treat COVID-19 and many other health problems – June 2021 04 Jun, 2021
COVID-19 treatment outside of hospital – Vitamin D, zinc, etc. – May 2021 12 May, 2021
Important Role of Micronutrients during COVID-19 (Zinc, Vitamin D, C, Folate) – May 5, 2021 06 May, 2021
Zinc therapy for COVID-19 – Feb 2021 19 Apr, 2021
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018 03 Mar, 2021
Zinc (which increases vitamin D in tissues) may both prevent and treat COVID-19 15 Feb, 2021
Vitamin D, Zinc, etc. look promising for COVID-19 (Holick) - Jan 25, 2021 28 Jan, 2021
COVID-19 possible therapies: Vitamin D, Selenium, Zinc, Vitamin C, Potassium, Resveratrol , etc.– Aug 5, 2020 09 Aug, 2020
7 reasons to think that Zinc should fight COVID-19 – July 2020 08 Aug, 2020
Mild COVID-19 quickly treated by Zinc lozenges in 4 people – June 6, 2020 29 Jun, 2020
Zinc, respiratory tract infections and COVID-19 – July 2020 07 Jun, 2020
Fight COVID-19 with Vitamin D, Vitamin C, Zinc, Selenium, Resveratrol, etc. - Sardi May 12, 2020 14 May, 2020
Loss of smell may be related to low Zinc or perhaps low vitamin D 11 Nov, 2018
Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015 11 Jun, 2016

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19167 Antioxidants and Long Covid_CompressPdf.pdf admin 01 Feb, 2023 737.35 Kb 114
19166 Anti-oxideants COVID.jpg admin 01 Feb, 2023 45.71 Kb 279
19165 antioxidant COVID_CompressPdf.pdf admin 01 Feb, 2023 484.98 Kb 107