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Overview Asthma and Vitamin D

Did you know?
  • Asthma is one of the most prevalent chronic diseases worldwide
  • Most asthmatics have low Vitamin D levels
  • Adding Vitamin D decreases asthma: proven by many random controlled trials
          (More Asthma info below)

Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
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If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Proof that Vitamin D Works   Getting Vitamin D into your body

Is 50ng enough?   How to restore levels quickly  VitaminDWiki interview and transcript - Jan 2022
Books and Videos 265   Diseases that may be related via low vitamin D
Reasons for low response to vitamin D   Why are doctors reluctant
Cancer studies include:   Breast 253   Colon 141   Lung 55   Prostate 101   Pancreatic 56   Skin 121
Colds and flu   Dark Skin 464   Diabetes 543   Obesity 434   Pregnancy 901   Seniors 431
COVID-19 treated by Vitamin D - studies, reports, videos

Overview VitaminDWiki

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
click on chart to see the study

Related pages in VitaminDWiki

15+ Intervention pages with ASTHMA in title

This list is automatically updated

Items found: 15
Title Modified
Resulting childhood Asthma cut in half if 4,400 IU Vitamin D (5 ways to improve it) - RCT April 2023 20 Apr, 2023
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 28 Jun, 2021
Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017 25 Jul, 2020
Those with Asthma or COPD had half the response to Vitamin D – March 2020 19 Mar, 2020
Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017 12 Mar, 2019
Vitamin D every 14 weeks is not often enough (asthma in this case)– Feb 2019 21 Feb, 2019
All asthma problems reduced after 1 year of Vitamin D – Nov 2017 10 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 24 Jun, 2018
Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 18 Jul, 2017
Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017 02 May, 2017
Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015 15 Jan, 2017
Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016 03 Aug, 2016
Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015 25 Nov, 2015
Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013 14 Sep, 2014
Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014 03 Aug, 2014

5+ Non-Daily Intervention pages with ASTHMA in title

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Items found: 5

2+ Magnesium pages with ASTHMA in title

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Items found: 2

8+ Vitamin D Receptor pages have ASTHMA in the title

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Items found: 9

13+ Meta-analyses in VitaminDWiki have ASTHMA in title

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Items found: 13

Vitamin D is cost-effective to give to asthmatic children in Columbia - Feb 2023

Vitamin D supplementation for children with mild to moderate asthma: an economic evaluation
J Asthma . 2023 Feb 8;1-13. doi: 10.1080/02770903.2023.2178007 PUBLISHER wants $62 for the PDF
Jefferson Antonio Buendía 1, Diana Guerrero Patiño 1, Erika Fernanda Lindarte 1

Introduction A large proportion of asthma patients remain uncontrolled despite using inhaled corticosteroids. Some add-on therapies such as vitamin D supplements have been recommended for this subgroup of patients. The purpose of this study was to assess the cost-utility of vitamin D supplementation in children with mild to moderate persistent asthma in Colombia.

Methods A probabilistic Markov model was created to estimate the cost and quality-adjusted life-years (QALYs) of patients with severe asthma in Colombia. The model was analyzed probabilistically, and a value of information (VOI) analysis was conducted to inform the value of conducting further research to reduce current uncertainties in the evidence base. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180.

Results The mean incremental cost of vitamin D supplementation versus no supplementation is USD $44.60. The mean incremental benefit of vitamin D supplementation versus no supplementation is 0.05 QALY. This position of absolute dominance (vitamin D supplementation has lower costs and higher QALYs than no supplementation) is unnecessary to estimate the incremental cost-effectiveness ratio. Our base-case results were robust to variations in all assumptions and parameters.

Conclusion Add-on therapy with vitamin D supplementation is a cost-effective strategy for patients between 6 and 17 years of age with mild to moderate asthma in Colombia.

4,400 IU of vitamin D during pregnancy did reduce Asthma (VIDDART) - Oct 2023

Unfortunately, the PDF is behind a paywall
Prenatal Vitamin D Supplementation to Prevent Childhood Asthma: 15-Year Results from the Vitamin D Antenatal Asthma Reduction Trial (VDAART)
J Allergy Clin Immunol . 2023 Oct 16:S0091-6749(23)01254-X. doi: 10.1016/j.jaci.2023.10.003
Scott T Weiss, Hooman Mirzakhani, Vincent J Carey, George T O'Connor, Robert S Zeiger, Leonard B Bacharier, Jeffrey Stokes, Augusto A Litonjua

This article provides an overview of the findings obtained from the Vitamin D Antenatal Asthma Reduction Trial (VDAART) spanning a period of 15 years. The review covers various aspects, including the trial's rationale, study design, initial intent-to-treat analyses, and an explanation of why those analyses did not achieve statistical significance. Additionally, the article delves into the post-hoc results obtained from stratified intent-to-treat analyses based on maternal vitamin D baseline levels and genotype stratified analyses.
These results demonstrate a statistically significant reduction in asthma among offspring aged 3 and 6 years when comparing vitamin D supplementation (4400 IU/day) to the standard prenatal multivitamin with vitamin D (400 IU/day). Furthermore, these post-hoc analyses found that vitamin D supplementation led to a decrease in total serum IgE levels and improved lung function in children, in comparison to those whose mothers received a placebo alongside the standard prenatal multivitamin with vitamin D. Lastly, the article concludes with recommendations regarding the optimal dosing of vitamin D for pregnant women to prevent childhood asthma, as well as suggestions for future trials in this field.

See asthma and Vitamin D on the web

5X less likely to be hospitalized for Asthma if adequate vitamin D
 Download the PDF from VitaminDWiki

Children born with higher vitamin D less likely to get asthma later - May 2021

The correlation between neonatal vitamin D levels and the risk of childhood asthma attacks
Transl Pediatr. 2021 Apr;10(4):914-920. doi: 10.21037/tp-21-92.
Wenlin Li 1, Jin Zhou 2, Shen Liu 2, Kaihui Xing 1, Ling Yang 1, Lihua Zhong 1, Qiuli Chen 2, Wei Zhang 1
 Download the PDF from VitaminDWiki

Background: To explore the correlation between neonatal vitamin D levels and the risk of asthma in children aged 3-9 years.

Methods: A total of 1,534 subjects were selected, and clinical and laboratory test data of all subjects were collected at birth, including 25-hydroxyvitamin D3 [25(OH)D3] levels, gender, season of birth, birth weight; whether delivery was premature, cesarean section, or primipara; and parental details including maternal age, ethnicity, level of education, history of smoking, and history of maternal or paternal asthma. The level of 25(OH)D3 was used as a continuous variable to analyze its correlation with the risk of asthma using the Cox proportional regression model. In addition, subjects were divided into four groups according to their 25(OH)D3 quartiles, and the first quantile group was used as a reference to analyze the risk of asthma in the other groups. Further subgroup analysis was conducted according to the patient's gender and birth season.

Results: Among the 1,534 subjects included, there were 107 cases in the asthma-affected group and 1,427 cases in the normal control group. Compared with the control group, the level of 25(OH)D3 in the asthma group was significantly lower (P=0.03), the mother's education level was lower (P=0.002), but the preterm birth rate, cesarean section rate, and parental asthma prevalence rate were significantly higher (all P<0.05). When the neonatal 25(OH)D3 was divided into quartiles to perform a categorical variable analysis, we found that compared with the first quantile (Q1, 0.0-25.1 mmol/L), the risk of asthma in Q4 was reduced by 50% (HR=0.50, 95% CI: 0.38-0.76). The second quantile group (Q2) and the third quantile group (Q3) showed no significant difference in the risk of disease compared with Q1 but showed a trend of decreasing risk as the quantile group increased (the trend P values were both <0.05). This correlation was still valid when a stratified analysis was made based on gender and birth season.

Conclusions: There is a significant correlation between a reduced vitamin D level in newborns and the subsequent risk of asthma in children aged 3-9 years. Moreover, the level of vitamin D is an independent risk factor for childhood asthma.

The worse the asthma in children, the lower their vitamin D level - Feb 2019

Serum 25-hydroxy vitamin D in asthmatic children and its relation to disease severity
International Journal o Community Medicine and Public Health, DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20185510
Ihab Hafez El Sawy, Passant Al-Said Moaz, Ghada Mohamed Farouk El Deriny, Mohamed Sami Abd El Moniem El Kholy

Background: Asthma is a chronic immunological disorder of the lungs. Vitamin D has several effects on the innate and adaptive immune systems. Little is known about vitamin D level and its impact on severity of asthma in children. This study aimed to determine vitamin D levels in asthmatics versus control children; studying the relation if any between these levels and asthma severity.

Methods: This cross-sectional study was conducted on 60 asthmatic children and 20 apparently healthy children as controls. Asthma patients were divided into 3 groups (mild, moderate, severe; 20 each). Asthma severity was based on GINA criteria. Vitamin D level was measured to all study group.

Results: The difference between the mean values of vitamin D level in control and asthmatic patients was statistically significant (p<0.001). This difference between control group and each asthma subgroup and between asthma subgroups versus each other were statistically significant being highest in control and lowest in patients with severe asthma (p<0.001). Differences in vitamin D status in control and all asthmatic patients were statistically significant (p<0.001). The difference between control group and each asthma subgroup according to vitamin D status were statistically significant (p<0.001). Concerning asthma subgroups the difference in vitamin D status between severe versus mild and moderate asthma were statistically significant (p<0.001), while between mild and moderate asthma it was not.

Conclusions: Significantly lower vitamin D level in asthmatic children compared to controls and a differential decrease in vitamin D levels in asthmatic children being lowest in severe asthma was confirmed.
 Download the PDF from VitaminDWiki

Asthma Drug Therapy (nothing about Vitamin D)


Asthma is the most common health problem in children, inhalers not used properly - March 2019

Using an Asthma Inhaler Correctly NYT

  • "Asthma is the most common chronic disease of childhood, and using an asthma inhaler is often a first step toward medical autonomy for a child with asthma"
  • "Once or twice a day, children may take what are called controller therapies, most often inhaled corticosteroids which decrease chronic inflammation in the lungs and make exacerbations less likely. And then, when they feel symptoms coming on, or find themselves in a situation where symptoms seem likely, they use what are called rescue medications, bronchodilators which relax the smooth muscle so that air can move through those tubes."
  • "You have to take off the cap, shake the inhaler for three to five seconds and connect it to the spacer (a chamber between the inhaler and the patient’s mouth that holds the drug suspended and makes it easier to breathe it in). Then you are supposed to exhale completely, and put the mouthpiece or mask in or around your mouth correctly, forming a tight seal. Then you release the medication from the inhaler by pressing the canister down, breathe in slowly and deeply through the spacer (for spacers with a whistle, you do not want to hear the whistle), and hold your breath for 10 seconds. Finally, you exhale again — and then you wait a minute and repeat the process."
  • "Eighty-four percent of the patients did not wait the 30 seconds that the researchers felt was the absolute minimum time between inhalations. More than 50 percent waited less than 15 seconds."

Asthma reduced by Diet, Magnesium, Vitamin D, Tumeric, Breathing Exercises, Pine Bark, Vit B6

8 Proven Ways To Relieve Asthma Naturally GreenMed Info Jan 2019

  • "Asthma affects about 300 million people worldwide.It is growing by 50 percent every decade and causes upwards of 180,000 deaths per year"
  • "In a study of 1,531 children in Manitoba, Canada, researchers found that the risk of developing asthma by the age of seven was cut in half when the first diphtheria, pertussis, tetanus (DPT) immunization was delayed by more than two months. Delaying all three doses of DPT vaccines cut asthma risk by 60 percent."

Asthma Factoids from The Body by Bill Bryson, 2019

  • The U.K.:30 percent of children have shown asthma symptoms.
    • The lowest rates are in China, Greece, Georgia, Romania, and Russia, with just 3 percent.
  • Pearce. “I have spent thirty years studying asthma, and the main thing I have achieved is to show that almost none of the things people think cause asthma actually do. They can provoke attacks if you have asthma already, but they don’t cause it. We have very little idea what the primary causes are. We can do nothing to prevent it.”
  • with some asthmatics if you put their feet in a bucket of ice water, they begin to wheeze immediately. Now, that can’t be due to inflammation, because it happens too fast.
  • Asthma is very different from other lung disorders in that it is normally present only some of the time.
  • Even when there are no symptoms present, other diseases will nearly always be evident in blood or sputum tests. In asthma, in some cases, the disease just vanishes.”

Asthma worse at night - Sept 2021

Why Does Asthma Get Worse at Night?
Had been known for centuries, now a clinical trial documented the reason

Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024

Overview Asthma and Vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
15615 Asthma.jpg admin 21 May, 2021 32.49 Kb 2268
15614 childhood asthma attacks.pdf admin 21 May, 2021 254.20 Kb 512
15048 There’s No ‘One Size Fits All’ Treatment for Asthma - The New York Times.pdf admin 15 Feb, 2021 114.33 Kb 621
15047 Asthma guidelines.pdf admin 15 Feb, 2021 1.21 Mb 1578
11142 Asthma Feb 2019.jpg admin 04 Jan, 2019 31.14 Kb 6175
11141 Asthma.pdf admin 04 Jan, 2019 373.00 Kb 1188
10990 Asthma Drug Therapy.jpg admin 06 Dec, 2018 108.66 Kb 7785
9778 Asthma 2018.pdf admin 26 Apr, 2018 336.88 Kb 1378
9777 MEF25 percent.jpg admin 26 Apr, 2018 16.03 Kb 6849
3277 Astham types.jpg admin 15 Nov, 2013 96.71 Kb 4099
3003 Asthma Sept 2013.jpg admin 15 Sep, 2013 47.55 Kb 20473
3002 Asthma Sept 2013.pdf admin 15 Sep, 2013 237.74 Kb 3002