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Lots of sugar while pregnant doubles asthma risk – 2017

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Maternal intake of sugar during pregnancy and childhood respiratory and atopic outcomes] July 2017

published by European Respiratory Society

  • “After controlling for potential confounders, maternal intake of free sugar was positively associated with atopy (OR for highest versus lowest quintile of sugar intake 1.38, 95% CI 1.06–1.78; per quintile p-trend=0.006) and atopic asthma (OR 2.01, 95% CI 1.23–3.29; per quintile p-trend=0.004). These associations were not confounded by intake of sugar in early childhood, which was unrelated to these outcomes.”

2X increase in atopic asthma if > 60 grams of sugar daily during pregnancy
"Atopy refers to the genetic tendency to develop allergic diseases such as allergic rhinitis, asthma and atopic dermatitis (eczema)." from Google

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Prenatal and Early-Life Fructose, Fructose-Containing Beverages, and Mid-Childhood Asthma - Dec 2017

Annals of the American Thoracic Society https://doi.org/10.1513/AnnalsATS.201707-530OC PubMed: 29219619
Lakiea S Wright ; Sheryl L Rifas-Shiman , Emily Oken , Augusto A Litonjua ; Diane R Gold ;

Rationale: Cross-sectional studies have linked intake of high fructose corn syrup sweetened beverages with asthma in school children.

Objective: To examine associations of maternal prenatal and early childhood intake of sugar sweetened beverages and fructose with current asthma in mid-childhood (median 7.7years).

Methods: We assessed maternal pregnancy (1st and 2nd trimester average) and child (median 3.3 years) intake of sugar sweetened beverages and total fructose using food frequency questionnaires in 1068 mother-child pairs from Project Viva, a prospective pre-birth cohort. In a multivariable analysis, we examined associations of quartiles of maternal and child sugar sweetened beverage, juice, and total fructose intake with child current asthma in mid-childhood, assessed by questionnaire as ever doctor-diagnosed asthma plus taking asthma medications or reporting wheezing in the past 12 months.

Results: Higher maternal pregnancy sugar sweetened beverage consumption (mean 0.6 servings/day; range 0-5) was associated with younger maternal age, non-white race/ethnicity, lower education and income, and higher pre-pregnancy BMI. Adjusting for pre-pregnancy BMI and other covariates, comparing quartile 4 v. quartile 1, higher maternal pregnancy intake of

  • sugar sweetened beverages (OR 1.70; 95%CI 1.08, 2.67) and
  • total fructose (OR 1.58; 0.98, 2.53)

were associated with greater odds of mid-childhood current asthma (prevalence=19%). Higher early childhood fructose intake (quartile 4 v. quartile 1) was also associated with mid-childhood current asthma in models adjusted for maternal sugar sweetened beverages (OR 1.79; 1.07, 2.97) and after additional adjustment for mid-childhood BMI z-score (OR 1.77; 1.06, 2.95).

Conclusion: Higher sugar sweetened beverage and fructose intake during pregnancy and in early childhood may influence childhood asthma development, in part through mechanisms apart from adiposity.
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Lots of sugar while pregnant doubles asthma risk – 2017        
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ID Name Comment Uploaded Size Downloads
17991 Fructose, asthma.pdf admin 28 Jun, 2022 545.29 Kb 129
8895 Atopic asthma.jpg admin 08 Dec, 2017 15.01 Kb 539
8894 Asthma sugar pregnancy.pdf admin 08 Dec, 2017 335.77 Kb 592