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Mild to moderate persistent asthma cost-effectively treated by Vitamin D – Aug 2022


Cost utility of Vitamin D supplementation in adults with mild to moderate asthma

J Asthma. 2022 Aug 3;1-13. doi: 10.1080/02770903.2022.2110113 PDF behind a $59 paywall
Jefferson Antonio Buendía, MD PhD, Carlos E. Rodriguez-Martinez., MD, MSc, PhD & Monica P. Sossa-Briceño, MD., MSc.

Introduction
Uncontrolled asthma significantly impairs health-related quality of life and work productivity. Some add-on therapies, such as vitamin D supplements, safely reduce the rate of asthma exacerbation. The purpose of this study was to assess the cost-utility of vitamin D supplementation in adults with mild to moderate persistent asthma in Colombia.

Methods
A Markov model was created to estimate the cost and quality-adjusted life-years (QALYs) of patients with severe asthma in Colombia. Total costs and QALYs of two therapy strategies, vitamin D supplementation plus ICS versus ICS alone, were calculated over a one-year time horizon. Deterministic and probability sensitivity analyses were conducted, and cost-effectiveness was evaluated at a willingness-to-pay value of $5,180 per QALY gained.

Results
The base-case analysis showed that compared with no supplementation, vitamin D supplementation was associated with higher costs and higher QALYs. The expected annual cost per patient with vitamin D supplementation was US$1338 and without this supplementation it was US$1095. The QALYs per person estimated with vitamin D supplementation was 0,80, and without this supplementation it was 0,63. The estimated incremental cost-effectiveness ratio (ICER) was US$1583 per QALY.

Conclusion
Add-on vitamin D supplement was cost-effective when added to the usual care in patients with mild to moderate persistent asthma. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines.


VitaminDWiki - Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
click on chart to see the study


Intervention pages with ASTHMA in title (14 as of July 2022)

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Items found: 14

Meta-analyses with ASTHMA in title (13 as of July 2022)

This list is automatically updated

Items found: 13

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