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Asthma treated by Vitamin D - 13th Meta-analysis – July 2022

A Meta-Analysis on Vitamin D Supplementation and Asthma Treatment

Frontiers in Nutrition 06 July 2022 doi: 10.3389/fnut.2022.860628
Meiqi Liu1, Jun Wang2 andXinrong Sun1*
1 Department of Respiratory Medicine, Xi’an Chiidren’s Hospital, Xi’an Jiaotong University, Xi’an, China,2 Department and Institute of Infectious Disease, Xi’an Chiidren’s Hospital, Xi’an Jiaotong University, Xi’an, China

Background: Vitamin D, as an immunomodulator, may be related to the therapeutic effect of asthma patients, but the research in this area is still controversial. The aim of this meta-analysis was to analyze the role of vitamin D supplementation in the treatment of asthma patients.

Materials and Methods: Randomized Controlled Trials (RCTs) of vitamin D supplementation in asthma were searched in PubMed, EMBASE, and the Cochrane library. Primary outcomes were forced expiratory volume in one second (FEV1), asthma exacerbations, Asthma Control Test scores (ACT scores), and fractional exhaled nitric oxide (FENO).

Results: A total of 10 RCTs were included, including 1,349 patients. Vitamin D supplementation didn’t affect the ACT scores (SMD = 0.04, 95% CI = -0.13 to 0.21, P = 0.87), FEV1 (SMD = 0.04, 95% CI = -0.35 to 0.43, P < 0.01) and FENO (SMD = -0.01, 95% CI = -0.22 to 0.20, P = 0.27), but reduced the rate of asthma exacerbations (RR = 0.69, 95% CI = 0.41 to 0.88, P < 0.01), especially in subgroups of children (RR = 0.46, 95% CI = 0.30 to 0.70, P = 0.83) and follow up time less than 6 months (RR = 0.45, 95% CI = 0.32 to 0.63, P = 0.95). Additionally, though there was only one study included in the subgroup, it significantly enhanced FEV1 at the last visit for patients whose FEV1 baseline value was less than 70% (SMD = 0.94, 95% CI = 0.47 to 1.41).

Conclusion: Vitamin D supplementation can reduce asthma exacerbations, especially in children, and within 6 months of follow up time. In addition, vitamin D has a positive effect on improving FEV1 of patients whose FEV1 baseline value is less than 70%, but more RCTs are still needed to support this conclusion.

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VitaminDwiki - Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
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VitaminDWiki Meta-analyses with ASTHMA in title (13 as of July 2022)

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Items found: 13

8 Asthma studies noticed the association with a poor vitamin D receptor

VitaminDWiki Vitamin D Receptor pages with ASTHMA in title
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Items found: 9

Attached files

ID Name Comment Uploaded Size Downloads
18047 Asthma meta.jpg admin 08 Jul, 2022 54.87 Kb 273
18046 Asthma meta_CompressPdf.pdf admin 08 Jul, 2022 770.27 Kb 184