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All asthma problems reduced after 1 year of Vitamin D – Nov 2017

Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement.

Nutrients. 2017 Nov 11;9(11). pii: E1234. doi: 10.3390/nu9111234.
Solidoro P1, Bellocchia M2, Aredano I3, Mattei A4, Pivetta E5, Patrucco F6, Boita M7, de Blasio F8, Brussino L9, Rolla G10, Bucca C11,12.

VitaminDWiki

For those asthmatics who had < 20 ng initially
Loading dose injection of 100,000 IU of vitamin D
Weekly 5,000 IU of vitamin D
Daily 400 IU of vitamin D & 1500 mg of Calcium


They would have had even more benefit if they had used high doses
- Initially 400,000 IU
- Weekly 50, 000 IU

Suspect that the injection form of the loading dosde and the daily Calcium were not needed


See also VitaminDWiki

Breathing category starts with the following

311 items in Breathing category

 Download the PDF from VitaminDWiki
Improved in every measure - if complied
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FEV1 (% of total air exhaled in 1 second)
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BACKGROUND: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL.

METHODS: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation.

RESULTS: 25-OHD was low in 111 patients and was negatively related to exacerbations (p < 0.001), inhaled CS dose (p = 0.008) and asthma severity (p = 0.001). Deficiency was found in 90 patients, 55 of whom took the supplement regularly for one year, while 24 discontinued the study and 11 were not adherent. Patients with vitamin D deficiency after 12 months supplementation showed significant decrease of exacerbations (from 2.6 ± 1.2 to 1.6 ± 1.1, p < 0.001), circulating eosinophils (from 395 ± 330 to 272 ± 212 10⁶/L, p < 0.001), and need of oral CS courses (from 35 to 20, p = 0.007) and improvement of airway obstruction.

CONCLUSIONS: Asthma exacerbations are favored by vitamin D deficiency and decrease after long-term vitamin D replacement. Patients who are vitamin D deficient benefit from vitamin D supplementation.

Created by admin. Last Modification: Tuesday July 10, 2018 15:13:03 UTC by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
10145 FEV1.jpg admin 10 Jul, 2018 14:37 26.34 Kb 13
10144 Asthma.jpg admin 10 Jul, 2018 14:37 54.89 Kb 15
10143 Asthmatic Patients with Vitamin D Deficiency.pdf admin 10 Jul, 2018 14:37 969.06 Kb 5
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