Vitamin D supplementation for children with mild to moderate asthma: an economic evaluation
Journal of Asthma Volume 60, 2023 - Issue 9 https://doi.org/10.1080/02770903.2023.2178007 PDF behind paywall
Jefferson Antonio Buendía , MD, PhDORCID Icon,Diana Guerrero Patiño , RN, MSc &Erika Fernanda Lindarte , MSc
Introduction
A large proportion of asthma patients remain uncontrolled despite using inhaled corticosteroids. Some add-on therapies such as vitamin D supplements have been recommended for this subgroup of patients. The purpose of this study was to assess the cost-utility of vitamin D supplementation in children with mild to moderate persistent asthma in Colombia.
Methods
A probabilistic Markov model was created to estimate the cost and quality-adjusted life-years (QALYs) of patients with severe asthma in Colombia. The model was analyzed probabilistically, and a value of information (VOI) analysis was conducted to inform the value of conducting further research to reduce current uncertainties in the evidence base. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180.
Results
The mean incremental cost of vitamin D supplementation versus no supplementation is USD $44.60. The mean incremental benefit of vitamin D supplementation versus no supplementation is 0.05 QALY. This position of absolute dominance (vitamin D supplementation has lower costs and higher QALYs than no supplementation) is unnecessary to estimate the incremental cost-effectiveness ratio. Our base-case results were robust to variations in all assumptions and parameters.
Conclusion
Add-on therapy with vitamin D supplementation is a cost-effective strategy for patients between 6 and 17 years of age with mild to moderate asthma in Colombia.
Overview Asthma and Vitamin D contains
- VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
- Started with 100,000 IU loading dose and has standard-of-care Asthma drug
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
- Those with Asthma need larger doses to get the same response.
- Probably need gut-friendly Vitamin D
- CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
- Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
- Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- CDC list of high-risk for COVID-19 includes Asthma
- Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
- Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
- Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
- Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
- If high vitamin D during pregnancy the child is 5X less likely to get asthma
- Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
- Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
- Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart
click on the chart to see the study
VitaminDWiki -Less Asthma if mother took vitamin D while pregnant – Oct 2023
VitaminDWiki - Cost savings with Vitamin D contains
- Vitamin D has been found to be cost-effective by many studies
- Estimated cost savings of getting most Canadians to 40 ng of Vitamin D - 2016
- Severe asthmatics willing to pay 5180 dollars for relief, Vitamin D needed costs only 45 dollars – Sept 2023
- People with extremely low vitamin D levels consume 2X more health care dollars – 2018
- Reduce 4 health problems by a quarter if increase Vitamin D to 30 ng – Saudi Arabia, Grant March 2023
- The top 10 medical expenses can all be decreased by vitamin D
- VA showed increased vitamin D associated with lower health costs - Lancet May 2012
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- People with extremely low vitamin D levels consume 2X more health care dollars – 2018
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Medical problems are thought to be a cause of 66 percent of bankruptcies – April 2019
- Vitamin D is the 3rd most important contributor to health, following exercise and food
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- Employers gain 10 dollars in productivity for every dollar spent on giving Vitamin D for free
- Employers should give night shift workers free vitamin D – GMB Union June 2019
- Biology of Vitamin D – 30ng min., 50ng preferred, 1000X lower cost than health problem – Feb 2019
- Dutch Vitamin D cost-effectivity Calculations (they prescribe 100,000 IU for Multiple Sclerosis) – Jan 2022
- Vitamin D is needed before most surgeries – many studies and RCTs
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- If you cannot readily get medical treatment, consider Alternative Med such as vitamin D
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