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Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022


Recent advances in vitamin D implications in chronic respiratory diseases

Respir Res. 2022 Sep 19;23(1):252. doi:10.1186/s12931-022-02147-x
Mellissa Gaudet 1 , Maria Plesa 1 , Andrea Mogas 1 , Nour Jalaleddine 2 , Qutayba Hamid 3 4 , Saba Al Heialy 5 6

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Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has been shown to be highly prevalent in patients with chronic airway inflammatory and infectious diseases, correlated with increased disease severity. It has been established that vitamin D modulates ongoing abnormal immune responses in chronic respiratory diseases and is shown to restrict bacterial and viral colonization into the lungs. On the contrary, other studies revealed controversy findings regarding vitamin D efficacy in respiratory diseases. This review aims to update the current evidence regarding the role of vitamin D in airway inflammation and in various respiratory diseases. A comprehensive search of the last five years of literature was conducted using MEDLINE and non-MEDLINE PubMed databases, Ovid MEDLINE, SCOPUS-Elsevier, and data from in vitro and in vivo experiments, including clinical studies. This review highlights the importance of understanding the full range of implications that vitamin D may have on lung inflammation, infection, and disease severity in the context of chronic respiratory diseases.
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PDF references
  1. Maes K, Serré J, Mathyssen C, Janssens W, Gayan-Ramirez G. Targeting vitamin D deficiency to limit exacerbations in respiratory diseases: utopia or strategy with potential? J Calcif Tissue Int. 2020;106(1):76–87. - DOI
  2. Gilbert CR, Arum SM, Smith CM. Vitamin D deficiency and chronic lung disease. J Can Respir J. 2009;16(3):75–80. - PubMed - DOI
  3. Shi Y, Liu T, Yao L, Xing Y, Zhao X, Fu J, et al. Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system. J Sci Rep. 2017;7(1):1–10. - DOI
  4. Maes K, Serre J, Mathyssen C, Janssens W, Gayan-Ramirez G. Targeting vitamin D deficiency to limit exacerbations in respiratory diseases: utopia or strategy with potential? Calcif Tissue Int. 2020;106(1):76–87. - PubMed - DOI
  5. Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, et al. Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients. Cancer Epidemiol Biomark Prevent. 2005;14(10):2303–9. - DOI
  6. Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Kostenberger M, Tmava Berisha A, et al. Vitamin D deficiency 20: an update on the current status worldwide. Eur J Clin Nutr. 2020. https://doi.org/10.1038/s41430-020-0558-y . - DOI - PubMed - PMC
  7. Mulrennan S, Knuiman M, Walsh JP, Hui J, Hunter M, Divitini M, et al. Vitamin D and respiratory health in the Busselton Healthy Ageing Study. Respirology. 2018;23(6):576–82. - PubMed - DOI
  8. Cherrie MPC, Sarran C, Osborne NJ. Association between Serum 25-hydroxy vitamin D levels and the prevalence of adult-onset asthma. Int J Environ Res Public Health. 2018. https://doi.org/10.3390/ijerph15061103 . - DOI - PubMed - PMC
  9. Han YY, Forno E, Celedon JC. Vitamin D insufficiency and asthma in a US nationwide study. J Allergy Clin Immunol Pract. 2017;5(3):790-6 e1. - PubMed - DOI
  10. Niruban SJ, Alagiakrishnan K, Beach J, Senthilselvan A. Association between vitamin D and respiratory outcomes in Canadian adolescents and adults. J asthma. 2015;52(7):653–61. - PubMed - DOI
  11. Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, et al. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res. 2019;20(1):161. - PubMed - PMC - DOI
  12. Martineau AR, Cates CJ, Urashima M, Jensen M, Griffiths AP, Nurmatov U, et al. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016;9: CD011511. - PubMed
  13. Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med. 2017;5(11):881–90. - PubMed - PMC - DOI
  14. Pfeffer PE. Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma? Expert Rev Clin Immunol. 2018;14(4):241–3. - PubMed - DOI
  15. Davidson BL, Alansari K. Vitamin D deficiency can impair respiratory health. Respirology. 2018;23(6):554–5. - PubMed - DOI
  16. Wang M, Liu M, Wang C, Xiao Y, An T, Zou M, et al. Association between vitamin D status and asthma control: a meta-analysis of randomized trials. J Respir Med. 2019;150:85–94. - DOI
  17. Chen Z, Peng C, Mei J, Zhu L, Kong HJNR. Vitamin D can safely reduce asthma exacerbations among corticosteroid-using children and adults with asthma: a systematic review and meta-analysis of randomized controlled trials. J Nutr Res. 2021;92:49–61. - DOI
  18. Rafiq R, Thijs W, Prein R, de Jongh RT, Taube C, Hiemstra PS, et al. Associations of serum 25(OH)D concentrations with lung function, airway inflammation and common cold in the general population. Nutrients. 2018. https://doi.org/10.3390/nu10010035 . - DOI - PubMed - PMC
  19. Anitua E, Tierno R, Alkhraisat MH. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: a need to establish publication guidelines for overcoming the unpublished data. J Clin Nutr. 2022. https://doi.org/10.1016/j.clnu.2022.01.029 . - DOI
  20. Poon AH, Mahboub B, Hamid Q. Vitamin D deficiency and severe asthma. J Pharmacol Ther. 2013;140(2):148–55. - DOI
  21. Mahboub B, Al Heialy S, Hachim MY, Ramakrishnan RK, Alzaabi A, Seliem RM, et al. Vitamin D regulates the expression of glucocorticoid receptors in blood of severe asthmatic patients. J Immunol Res. 2021. https://doi.org/10.1155/2021/9947370 . - DOI - PubMed - PMC
  22. Konstantinopoulou S, Tapia IE. Vitamin D and the lung. Paediatr Respir Rev. 2017;24:39–43. - PubMed
  23. Pfeffer PE, Hawrylowicz CM. Vitamin D in asthma: mechanisms of action and considerations for clinical trials. Chest. 2018;153(5):1229–39. - PubMed - DOI
  24. Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, et al. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res. 2019;20(1):161.
  25. Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, et al. Vitamin D supplementation during pregnancy: effect on the neonatal immune system in a randomized controlled trial. J Allergy Clin Immunol. 2018;141(1):269-78 e1. - PubMed - DOI
  26. Litonjua AA. Vitamin D and childhood asthma: causation and contribution to disease activity. Curr Opin Allergy Clin Immunol. 2019;19(2):126–31. - PubMed - PMC - DOI
  27. Kumar J, Kumar P, Goyal JP, Thakur C, Choudhary P, Meena J, et al. Vitamin D supplementation in childhood asthma: a systematic review and meta-analysis of randomised controlled trials. ERJ Open Res. 2022. https://doi.org/10.1183/23120541.00662-2021 . - DOI - PubMed
  28. Nitzan I, Mimouni FB, Nun AB, Kasirer Y, Mendlovic J. Vitamin D and asthma: a systematic review of clinical trials. J Curr Nutr Rep. 2022. https://doi.org/10.1007/s13668-022-00411-6 . - DOI
  29. Brustad N, Yousef S, Stokholm J, Bønnelykke K, Bisgaard H, Chawes BL. Safety of high-dose vitamin D supplementation among children aged 0 to 6 years: a systematic review and meta-analysis. J JAMA Netw Open. 2022;5(4): e227410-e. - DOI
  30. Amorim CLCGd, Oliveira JMd, Rodrigues A, Furlanetto KC, Pitta FJJBdP. Vitamin D: association with eosinophil counts and IgE levels in children with asthma. J Jornal Brasileiro de Pneumologia. 2020;47:(1):e20200279.
  31. de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol. 2015;135(3):670-5. e3. - PubMed - DOI
  32. Hall SC, Agrawal DK. Vitamin D and bronchial asthma: an overview of data from the past 5 years. Clin Ther. 2017;39(5):917–29. - PubMed - PMC - DOI
  33. Se Wook Cho JHK, Ji Ho Choi, Dae Hyun Lim. Preventive and therapeutic effects of vitamin D in a mouse model of allergic asthma. Asian Pacific J Allergy Immunol. 2018:37(3):130–7.
  34. Souto Filho JTD, de Andrade AS, Ribeiro FM, Alves PAS, Simonini VRF. Impact of vitamin D deficiency on increased blood eosinophil counts. Hematol Oncol Stem Cell Ther. 2018;11(1):25–9. - PubMed - DOI
  35. Szymczak-Pajor I, Kleniewska P, Wieczfinska J, Pawliczak R. Wide-range effects of 1,25(OH)2D3 on Group 4A phospholipases is related to nuclear factor kappa-B and phospholipase-A2 activating protein activity in mast cells. Int Arch Allergy Immunol. 2020;181(1):56–70. - PubMed - DOI
  36. Pfeffer PE, Lu H, Mann EH, Chen YH, Ho TR, Cousins DJ, et al. Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter. PLoS ONE. 2018;13(8): e0200040. - PubMed - PMC - DOI
  37. Plesa M, Gaudet M, Mogas A, Jalaleddine N, Halayko A, Al Heialy S, et al. Vitamin D3 attenuates viral-induced inflammation and fibrotic responses in bronchial smooth muscle cells. J Front Immunol. 2021. https://doi.org/10.3389/fimmu.2021.715848 . - DOI
  38. Sun D, Luo F, Xing JC, Zhang F, Xu JZ, Zhang ZH. 1,25(OH)2 D3 inhibited Th17 cells differentiation via regulating the NF-kappaB activity and expression of IL-17. Cell Prolif. 2018;51(5): e12461. - PubMed - PMC - DOI
  39. Shabana MA, Esawy MM, Ismail NA, Said AM. Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Immunobiology. 2019;224(6):721–7. - PubMed - DOI
  40. Ilyas M, Agussalim A, Megawati M, Massi N, Djaharuddin I, Bakri S, et al. Relationship between vitamin D level and serum TNF-α concentration on the severity of chronic obstructive pulmonary disease. Open Access Maced J Med Sci. 2019;7(14):2298–304. - PubMed - PMC - DOI
  41. Persson LJ, Aanerud M, Hiemstra PS, Michelsen AE, Ueland T, Hardie JA, et al. Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD. PLoS ONE. 2015;10(3): e0121622. - PubMed - PMC - DOI
  42. Mekov E, Slavova Y, Tsakova A, Genova M, Kostadinov D, Minchev D, et al. Vitamin D deficiency and insufficiency in hospitalized COPD patients. PLoS ONE. 2015;10(6): e0129080. - PubMed - PMC - DOI
  43. Zhang L, Yuan QY. Vitamin D should be supplemented more actively in elderly patients with coronary heart disease combined with COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:1359–65. - PubMed - PMC
  44. Martineau AR, James WY, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, et al. Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2015;3(2):120–30. - PubMed - DOI
  45. Sanjari M, Soltani A, Habibi Khorasani A, Zareinejad M. The effect of vitamin D on COPD exacerbation: a double blind randomized placebo-controlled parallel clinical trial. J Diabetes Metab Disord. 2015;15(1):33. - PubMed - DOI
  46. Rafiq R, Aleva FE, Schrumpf JA, Daniels JM, Bet PM, Boersma WG, et al. Vitamin D supplementation in COPD patients with low serum vitamin D: a randomized controlled trial. Am J Clin Nutr. 2022. https://doi.org/10.1093/ajcn/nqac083 . - DOI - PubMed - PMC
  47. Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, et al. High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2012;156(2):105–14. - PubMed - DOI
  48. Seymour JM, Spruit MA, Hopkinson NS, Natanek SA, Man WD, Jackson A, et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J. 2010;36(1):81–8. - PubMed - DOI
  49. Swallow EB, Reyes D, Hopkinson NS, Man WD, Porcher R, Cetti EJ, et al. Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax. 2007;62(2):115–20. - PubMed - DOI
  50. Jones SE, Maddocks M, Kon SS, Canavan JL, Nolan CM, Clark AL, et al. Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax. 2015;70(3):213–8. - PubMed - DOI
  51. Franco C, Paz-Filho G, Gomes P, Nascimento V, Kulak C, Boguszewski C, et al. Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D. Osteoporos Int. 2009;20(11):1881–7. - PubMed - DOI
  52. Sohl E, van Schoor NM. Implementation of the Dutch vitamin D supplementation advice: report of an expert meeting. J Nederlands Tijdschrift Voor Geneeskunde. 2015;159:A8171-A.
  53. Zendedel A, Gholami M, Anbari K, Ghanadi K, Bachari EC, Azargon A. Effects of vitamin D intake on FEV1 and COPD exacerbation: a randomized clinical trial study. Glob J Health Sci. 2015;7(4):243–8. - PubMed - PMC - DOI
  54. Rafiq R, Prins HJ, Boersma WG, Daniels JM, den Heijer M, Lips P, et al. Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial. Int J Chron Obstruct Pulmon Dis. 2017;12:2583–92. - PubMed - PMC - DOI
  55. Heulens N, Korf H, Cielen N, De Smidt E, Maes K, Gysemans C, et al. Vitamin D deficiency exacerbates COPD-like characteristics in the lungs of cigarette smoke-exposed mice. Respir Res. 2015;16:110. - PubMed - PMC - DOI
  56. Cielen N, Heulens N, Maes K, Carmeliet G, Mathieu C, Janssens W, et al. Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model. J Endocrinol. 2016;229(2):97–108. - PubMed - PMC - DOI
  57. Mangas-Sánchez C, Garriga-García M, Serrano-Nieto MJ, García-Romero R, Álvarez-Beltrán M, Crehuá-Gaudiza E, et al. Vitamin D status in pediatric and young adult cystic fibrosis patients. Are the new recommendations effective? J Nutrients. 2021;13(12):4413. - DOI
  58. Pincikova T, Svedin E, Domsgen E, Flodström-Tullberg M, Hjelte LJAP. Cystic fibrosis bronchial epithelial cells have impaired ability to activate vitamin D. J Acta Paediatr. 2016;105(7):851–3. - DOI
  59. Moustaki M, Loukou I, Priftis KN, Douros K. Role of vitamin D in cystic fibrosis and non-cystic fibrosis bronchiectasis. World J Clin Pediatr. 2017. https://doi.org/10.5409/wjcp.v6.i3.132 . - DOI - PubMed - PMC
  60. Abu-Fraiha Y, Elyashar-Earon H, Shoseyov D, Cohen-Cymberknoh M, Armoni S, Kerem E, et al. Increasing vitamin D serum levels is associated with reduced pulmonary exacerbations in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2019;68(1):110–5. - PubMed - DOI
  61. Pincikova T, Paquin-Proulx D, Sandberg JK, Flodstrom-Tullberg M, Hjelte L. Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial. Eur J Clin Nutr. 2017;71(2):203–5. - PubMed - DOI
  62. Loukou I, Moustaki M, Sardeli O, Plyta M, Douros K. Association of vitamin D status with lung function measurements in children and adolescents with cystic fibrosis. Pediatr Pulmonol. 2019. https://doi.org/10.1002/ppul.24460 . - DOI - PubMed
  63. Le TN. Updates in vitamin D therapy in cystic fibrosis. Curr Opin Endocrinol Diabetes Obes. 2018;25(6):361–5. - PubMed - DOI
  64. Hansdottir S, Monick MM, Hinde SL, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol. 2008;181(10):7090–9. - PubMed - DOI
  65. Chishimba L, Thickett DR, Stockley RA, Wood AM. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax. 2010;65(5):456–62. - PubMed - DOI
  66. McNally P, Coughlan C, Bergsson G, Doyle M, Taggart C, Adorini L, et al. Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis. J Cyst Fibros. 2011;10(6):428–34. - PubMed - DOI
  67. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770–3. - PubMed - DOI
  68. Olszowiec-Chlebna M, Koniarek-Maniecka A, Brzozowska A, Blauz A, Rychlik B, Stelmach I. Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa—pilot study. Ital J Pediatr. 2019;45(1):41. - PubMed - PMC - DOI
  69. Dauletbaev N, Herscovitch K, Das M, Chen H, Bernier J, Matouk E, et al. Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1. Br J Pharmacol. 2015;172(19):4757–71. - PubMed - PMC - DOI
  70. Morin G, Orlando V, St-Martin Crites K, Patey N, Mailhot G. Vitamin D attenuates inflammation in CFTR knockdown intestinal epithelial cells but has no effect in cells with intact CFTR. Am J Physiol Gastrointest Liver Physiol. 2016;310(8):G539–49. - PubMed - DOI
  71. Castoldi A, Herr C, Niederstrasser J, Labouta HI, Melero A, Gordon S, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2017;118:62–7. - PubMed - DOI
  72. Chen L, Eapen MS, Zosky GR. Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide. Sci Rep. 2017;7:45172. - PubMed - PMC - DOI
  73. Pincikova T, Paquin-Proulx D, Sandberg JK, Flodstrom-Tullberg M, Hjelte L. Vitamin D treatment modulates immune activation in cystic fibrosis. Clin Exp Immunol. 2017;189(3):359–71. - PubMed - PMC - DOI
  74. DiFranco KM, Mulligan JK, Sumal AS, Diamond G. Induction of CFTR gene expression by 1,25(OH)2 vitamin D3, 25OH vitamin D3, and vitamin D3 in cultured human airway epithelial cells and in mouse airways. J Steroid Biochem Mol Biol. 2017;173:323–32. - PubMed - PMC - DOI
  75. Richeldi L, Collard HR, Jones MG. Idiopathic pulmonary fibrosis. Lancet. 2017;389(10082):1941–52. - PubMed - DOI
  76. Chanda D, Otoupalova E, Smith SR, Volckaert T, De Langhe SP, Thannickal VJ. Developmental pathways in the pathogenesis of lung fibrosis. Mol Aspects Med. 2019;65:56–69. - PubMed - DOI
  77. Chang J, Nie H, Ge X, Du J, Liu W, Li X, et al. Vitamin D suppresses bleomycin-induced pulmonary fibrosis by targeting the local renin–angiotensin system in the lung. J Sci Rep. 2021;11(1):1–12. - DOI
  78. Tzilas V, Bouros E, Barbayianni I, Karampitsakos T, Kourtidou S, Ntassiou M, et al. Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis. Pulm Pharmacol Ther. 2019;55:17–24. - PubMed - DOI
  79. Zumla A, Geore A, Sharma V, Herbert RH, Oxley A, Oliver M, et al. The WHO 2014 global tuberculosis report—further to go. Lancet Glob Health. 2015;3(1):e10–2. - PubMed - DOI
  80. Aibana O, Huang CC, Aboud S, Arnedo-Pena A, Becerra MC, Bellido-Blasco JB, et al. Vitamin D status and risk of incident tuberculosis disease: a nested case-control study, systematic review, and individual-participant data meta-analysis. PLoS Med. 2019;16(9): e1002907. - PubMed - PMC - DOI
  81. Soeharto DA, Rifai DA, Marsudidjadja S, Roekman AE, Assegaf CK, Louisa M. Vitamin D as an adjunctive treatment to standard drugs in pulmonary tuberculosis patients: an evidence-based case report. Adv Prev Med. 2019;2019:5181847. - PubMed - PMC - DOI
  82. Tukvadze N, Sanikidze E, Kipiani M, Hebbar G, Easley KA, Shenvi N, et al. High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial. Am J Clin Nutr. 2015;102(5):1059–69. - PubMed - PMC - DOI
  83. Ganmaa D, Munkhzul B, Fawzi W, Spiegelman D, Willett WC, Bayasgalan P, et al. High-dose vitamin D during tuberculosis treatment in Mongolia: a randomized controlled trial. Am J Respir Crit Care Med. 2017;196(5):628–37. - PubMed - PMC - DOI
  84. Mily A, Rekha RS, Kamal SM, Arifuzzaman AS, Rahim Z, Khan L, et al. Significant effects of oral phenylbutyrate and vitamin D3 adjunctive therapy in pulmonary tuberculosis: a randomized controlled trial. PLoS ONE. 2015;10(9): e0138340. - PubMed - PMC - DOI
  85. Daley P, Jagannathan V, John KR, Sarojini J, Latha A, Vieth R, et al. Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2015;15(5):528–34. - PubMed - DOI
  86. Afzal A, Rathore R, Butt NF, Randhawa FA. Efficacy of Vitamin D supplementation in achieving an early sputum conversion in smear positive pulmonary tuberculosis. Pak J Med Sci. 2018;34(4):849–54. - PubMed - PMC - DOI
  87. Jolliffe DA, Ganmaa D, Wejse C, Raqib R, Haq MA, Salahuddin N, et al. Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data. Eur Respir J. 2019. https://doi.org/10.1183/13993003.02003-2018 . - DOI - PubMed
  88. Daley T, Hughan K, Rayas M, Kelly A, Tangpricha V. Vitamin D deficiency and its treatment in cystic fibrosis. J Cyst Fibros. 2019;18(Suppl 2):S66–73. - PubMed - DOI
  89. Bhatt K, Rafi W, Shah N, Christakos S, Salgame P. Induction of cathelicidin-mediated antimicrobial pathway against intracellular M. tuberculosis by 1,25-dihydroxyvitamin D. Sci Rep. 2016;6:34469. - PubMed - PMC - DOI
  90. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403. - PubMed - DOI
  91. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83(5):584–94. - PubMed - DOI
  92. Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011. https://doi.org/10.1016/j.ccm.2011.09.001 . - DOI - PubMed - PMC
  93. Baldini EH, Barnes PJ, DM D, Jett FJR, Ross ME. Women and lung cancer. Ann Oncol. 2006; p. 17 Suppl 2:ii79-82. https://doi.org/10.1093/annonc/mdj932 .
  94. Park B, Kim Y, Lee J, Lee N, Jang SHJC. Sex difference and smoking effect of lung cancer incidence in Asian population. J Cancers. 2021;13(1):113. - DOI
  95. Samet JM, Avila-Tang E, Boffetta P, Hannan LM, Olivo-Marston S, Thun MJ, et al. Lung cancer in never smokers: clinical epidemiology and environmental risk factors. J Clin Cancer Res. 2009;15(18):5626–45. - DOI
  96. Jeon S-M, Shin E-A. Exploring vitamin D metabolism and function in cancer. J Exp Mol Med. 2018;50(4):1–14.
  97. Wu X, Hu W, Lu L, Zhao Y, Zhou Y, Xiao Z, et al. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment. J Acta Pharmaceutica Sinica B. 2019;9(2):203–19. - DOI
  98. Zhou W, Heist RS, Liu G, Asomaning K, Neuberg DS, Hollis BW, et al. Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients. J Clin Oncol. 2007;25(5):479–85. - PubMed - DOI
  99. Heist RS, Zhou W, Wang Z, Liu G, Neuberg D, Su L, et al. Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer. J Clin Oncol. 2008;26(34):5596–602. - PubMed - PMC - DOI
  100. Akiba T, Morikawa T, Odaka M, Nakada T, Kamiya N, Yamashita M, et al. Vitamin D supplementation and survival of patients with non–small cell lung cancer: a randomized, double-blind, placebo-controlled trial. J Clin Cancer Res. 2018;24(17):4089–97. - DOI
  101. Liu J, Dong Y, Lu C, Wang Y, Peng L, Jiang M, et al. Meta-analysis of the correlation between vitamin D and lung cancer risk and outcomes. J Oncotarget. 2017;8(46):81040. - DOI
  102. Cusato J, Genova C, Tomasello C, Carrega P, Ottonello S, Pietra G, et al. Influence of vitamin D in advanced non-small cell lung cancer patients treated with nivolumab. Cancers (Basel). 2019. https://doi.org/10.3390/cancers11010125 . - DOI - PubMed - PMC
  103. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, et al. Acute respiratory distress syndrome. J Nat Rev Dis Prim. 2019;5(1):1–22. - DOI
  104. Dancer RC, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). J Thorax. 2015;70(7):617–24. - DOI
  105. Dancer RC, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015;70(7):617–24. - PubMed - DOI
  106. Parekh D, Dancer RC, Scott A, D’Souza VK, Howells PA, Mahida RY, et al. Vitamin D to prevent lung injury following esophagectomy—a randomized, placebo-controlled trial. J Crit Care Med. 2018;46(12): e1128. - DOI
  107. Zheng S, Yang J, Hu X, Li M, Wang Q, Dancer RCA, et al. Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition. Biochem Pharmacol. 2020;177: 113955. - PubMed - DOI
  108. Wu D, Wu T, Liu Q, Yang Z. The SARS-CoV-2 outbreak: what we know. Int J Infect Dis. 2020;94:44–8. - PubMed - PMC - DOI
  109. Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020;25(3):278. - PubMed - PMC - DOI
  110. Sungnak W, Huang N, Bécavin C, Berg M, Network HLB. SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways. ArXiv. 2020; arXiv:2003.06122v1 .
  111. Li X, Ma XJCC. Acute respiratory failure in COVID-19: is it “typical” ARDS? J Crit Care. 2020;24(1):1–5. - DOI
  112. Gibson PG, Qin L, Puah SH. COVID-19 acute respiratory distress syndrome (ARDS): clinical features and differences from typical pre-COVID-19 ARDS. Med J Aust. 2020;213(2):54–61. - PubMed - PMC - DOI
  113. Quesada-Gomez JM, Entrenas-Castillo M, Bouillon R. Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections. J Steroid Biochem Mol Biol. 2020;202: 105719. - PubMed - PMC - DOI
  114. Santaolalla A, Beckmann K, Kibaru J, Josephs D, Van Hemelrijck M, Irshad S. Association between vitamin D and novel SARS-CoV-2 respiratory dysfunction—a scoping review of current evidence and its implication for COVID-19 pandemic. J Front Physiol. 2020;11:1527.
  115. Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020;32(7):1195–8. - PubMed - PMC - DOI
  116. Panagiotou G, Tee SA, Ihsan Y, Athar W, Marchitelli G, Kelly D, et al. Low serum 25-hydroxyvitamin D (25OHD) levels in patients hospitalised with COVID-19 are associated with greater disease severity. Clin Endocrinol. 2020;93(4):508–11. - DOI
  117. Crane-Godreau MA, Clem KJ, Payne P, Fiering S. Vitamin D deficiency and air pollution exacerbate COVID-19 through suppression of antiviral peptide LL37. Front Public Health. 2020;8:232. - PubMed - PMC - DOI
  118. Getachew B, Tizabi Y. Vitamin D and COVID-19: role of ACE2, age, gender, and ethnicity. J Med Virol. 2021;93(9):5285–94. - PubMed - PMC - DOI
  119. Xiao D, Li X, Su X, Mu D, Qu Y. Could SARS-CoV-2-induced lung injury be attenuated by vitamin D? Int J Infect Dis. 2021;102:196–202. - PubMed - DOI
  120. Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, et al. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). J Postgrad Med J. 2022;98(1156):87–90. - PubMed
  121. Ramalho MJ, Coelho MAN, Pereira MC. Nanoparticles for delivery of vitamin D: challenges and opportunities. In: Gowder S, editor. A critical evaluation of vitamin D—clinical overview. London: InTech; 2017. https://doi.org/10.5772/64516 . - DOI
  122. Glowka E, Stasiak J, Lulek JJP. Drug delivery systems for vitamin D supplementation and therapy. J Pharm. 2019;11(7):347.
  123. Nasiruddin M, Neyaz M, Das S. Nanotechnology-based approach in tuberculosis treatment. J Tuberc Res Treat. 2017. https://doi.org/10.1155/2017/4920209 . - DOI
  124. Di Pierro F. A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SAR S-CoV-2. Minerva Med. 2020. https://doi.org/10.23736/S0026-4806.20.06570-2 . - DOI - PubMed
  125. He Y, Wen Q, Yao F, Xu D, Huang Y, Wang J. Gut-lung axis: the microbial contributions and clinical implications. Crit Rev Microbiol. 2017;43(1):81–95. - PubMed - DOI
  126. David A Jolliffe CS, Zhican Wang, Nazanin Z Kermani, Vassil Dimitrov, John H White, John E McDonough, Wim Janssens, Paul Pfeffer, Christopher J Griffiths, Andrew Bush, Yike Guo, Stephanie Christenson, Ian M Adcock, Kian Fan Chung, Kenneth E Thummel and Adrian R Martineau. Vitamin D Metabolism is Dysregulated in asthma and Chronic Obstructive Pulmonary Disease. Amer J Respirat Critic Care Med. 2020;202(3):371–82.
  127. Maurya VK, Bashir K, Aggarwal M. Vitamin D microencapsulation and fortification: trends and technologies. J Steroid Biochem Mol Biol. 2020;196: 105489. - PubMed - DOI
  128. Choi M, Gu J, Lee M, Rhim T. A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA. Gene Ther. 2017;24(11):727–34. - PubMed - DOI
  129. Kang Q, Zhang X, Liu S, Huang F. Correlation between the vitamin D levels and asthma attacks in children: evaluation of the effects of combination therapy of atomization inhalation of budesonide, albuterol and vitamin D supplementation on asthmatic patients. Exp Ther Med. 2018;15(1):727–32. - PubMed
  130. Qian J, Xu Y, Yu Z. Budesonide and calcitriol synergistically inhibit airway remodeling in asthmatic mice. Can Respir J. 2018;2018:5259240. - PubMed - PMC - DOI
  131. Mehta AA, Agrawal AD, Appanna V, Chaudagar KK. Vitamin D improves corticosteroid efficacy and attenuates its side-effects in an animal model of asthma. Can J Physiol Pharmacol. 2015;93(1):53–61. - PubMed - DOI
  132. Luo W, Johnson CS, Trump DL. Vitamin D signaling modulators in cancer therapy. Vitam Horm. 2016;100:433–72. - PubMed - DOI
  133. Baud D, Dimopoulou Agri V, Gibson GR, Reid G, Giannoni E. Using probiotics to flatten the curve of coronavirus disease COVID-2019 pandemic. Front Public Health. 2020. https://doi.org/10.3389/fpubh.2020.00186 . - DOI - PubMed - PMC


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