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Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016

Maternal vitamin D status during pregnancy and risk of childhood asthma a meta-analysis of prospective studies

Molecular Nutrition & Food Research, Accepted 16 Dec 2016, DOI: 10.1002/mnfr.20160065
Huihui Song, Lei Yang, Chongqi Jia

VitaminDWiki

The study is behind a $38 paywall
Probably this, like most other meta-analyses, did not consider Vitamin D dose size
   Thus they would assign the same importance to 400 IU as 6,000 IU
Speculate: A good level of vitamin D (> 40 ng with >6,000 IU) would reduce childhood asthma by >40 %

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D - many benefits

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial


Scope
Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma.

Methods and results
A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma. The fixed or random-effect model was selected based on the heterogeneity test among studies. Nonlinear dose–response relationship was assessed by restricted cubic spline model.
Fifteen prospective studies with 12,758 participants and 1,795 cases were included in the meta-analysis. The pooled RR of childhood asthma comparing the highest versus lowest category of maternal 25(OH)D levels was 0.87 (95% confidence interval, CI, 0.75-1.02). For dose–response analysis, evidence of a U-shaped relationship was found between maternal 25(OH)D levels and risk of childhood asthma (P-nonlinearity = 0.02), with the lowest risk at approximately 70 nmol/L of 25(OH)D.

Conclusion
This dose–response meta-analysis suggested a U-shaped relationship between maternal blood 25(OH)D levels and risk of childhood asthma. Further studies are needed to confirm the association.

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