Vitamin D status in pregnant women with asthma and its association with adverse respiratory outcomes during infancy.
J Matern Fetal Neonatal Med. 2018 Jan 5:1-6. doi: 10.1080/14767058.2017.1419176. [Epub ahead of print]
Healthy pregnancies need lots of vitamin D has the following summary
|0. Chance of not conceiving||3.4 times||Observe|
|1. Miscarriage||2.5 times||Observe|
|2. Pre-eclampsia||3.6 times||RCT|
|3. Gestational Diabetes||3 times||RCT|
|4. Good 2nd trimester sleep quality||3.5 times||Observe|
|5. Premature birth||2 times||RCT|
|6. C-section - unplanned||1.6 times||Observe|
|Stillbirth - OMEGA-3||4 times||RCT - Omega-3|
|7. Depression AFTER pregnancy||1.4 times||RCT|
|8. Small for Gestational Age||1.6 times||meta-analysis|
|9. Infant height, weight, head size |
within normal limits
|10. Childhood Wheezing||1.3 times||RCT|
|11. Additional child is Autistic||4 times||Intervention|
|12.Young adult Multiple Sclerosis||1.9 times||Observe|
|13. Preeclampsia in young adult||3.5 times||RCT|
|14. Good motor skills @ age 3||1.4 times||Observe|
|15. Childhood Mite allergy||5 times||RCT|
|16. Childhood Respiratory Tract visits||2.5 times||RCT|
RCT = Randomized Controlled Trial
- Childhood Asthma risk greatly reduced when mothers having high vitamin D were given 4,400 IU daily – RCT 2019
- Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018
- Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018
- Lots of sugar while pregnant doubles asthma risk – 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Birth asphyxia 2.4 times more likely if mother was vitamin D deficient – 2016
- Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Asthmatic pregnant women had 30 percent more preterm births if air pollution (vitamin D not mentioned) – March 2016
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Asthma trial underway - 4,000 IU during pregnancy - March 2014
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013
- Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013
- Dial D for danger – absurd editorial in Thorax – Oct 2012
- High maternal vitamin D resulted in 30 percent less infant problems with breathing – Nov 2011
- Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011
- 800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010
- Vitamin D Newsletter May 2010
- Winter babies are more prone to food allergies
Jensen ME1, Murphy VE1, Gibson PG2,3, Mattes J1,4, Camargo CA Jr5.
1 Priority Research Centre Grow Up Well, University of Newcastle and Hunter Medical Research Institute , Newcastle , Australia.
2 Department of Respiratory and Sleep Medicine , John Hunter Hospital , Newcastle , Australia.
3 Priority Research Centre for Healthy Lungs, University of Newcastle and Hunter Medical Research Institute , Newcastle , Australia.
4 Respiratory Department , John Hunter Children's Hospital , Newcastle , Australia.
5 Department of Emergency Medicine , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.
Vitamin D may influence pregnancy and infant outcomes, especially infant respiratory health. This study aimed to examine vitamin D status in pregnant women with asthma, and whether higher vitamin D levels are associated with fewer adverse respiratory outcomes in their infants.
Pregnant women with asthma, recruited from John Hunter Hospital Newcastle Australia (latitude 33°S), had serum total 25-hydroxyvitamin-D (25(OH)D) measured at 16 and 35 weeks gestation. Infant respiratory outcomes were collected at 12 months by parent-report questionnaire. Mother-infant dyads were grouped by serum 25(OH)D during pregnancy: 25(OH)D < 75 nmol/L (at both time-points) versus 25(OH)D ≥ 75 nmol/L (at one or both time-points).
In 52 pregnant women with asthma, mean serum 25(OH)D levels were 61 (range 26-110) nmol/L at 16 weeks, and 65 (range 32-116) nmol/L at 35 weeks, gestation. Thirty-one (60%) women had 25(OH)D < 75 nmol/L at both time-points; 21 (40%) had 25(OH)D ≥ 75 nmol/L at one or both time-points. Maternal 25(OH)D < 75 nmol/L during pregnancy was associated with a higher proportion of infants with "wheeze ever" at 12 months, compared with 25(OH)D ≥ 75 nmol/L (71 versus 43%, p = .04). Infant acute-care presentations (45 versus 13%, p = .02) and oral corticosteroid use (26 versus 4%, p = .03) due to "asthma/wheezing" were higher in the maternal group with 25(OH)D < 75 nmol/L, versus ≥75 nmol/L.
Most pregnant women with asthma had low vitamin D status, which persisted across gestation. Low maternal vitamin D status was associated with greater risk of adverse respiratory outcomes in their infants, a group at high risk of developing childhood asthma.
PMID: 29303025 DOI: 10.1080/14767058.2017.1419176