Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood
JAMA Pediatr. online April 2, 2018. doi:10.1001/jamapediatrics.2018.0315
Edward Mitre, MD1; Apryl Susi, MS2; Laura E. Kropp, MPH1; et al David J. Schwartz, MD3; Gregory H. Gorman, MD2; Cade M. Nylund, MD2
- Question Does use of medications that disturb the microbiome in infancy increase subsequent risk of developing allergic diseases?
- Findings In this cohort study of 792 130 children, the hazard of developing an allergic disease was significantly increased in those who had received acid-suppressive medications or antibiotics during the first 6 months of life.
- Meaning Exposure to acid-suppressive medications or antibiotics in the first 6 months of life may increase risk of allergic disease development.
- Huge increases in health problems – risk factors include Vitamin D, Antibiotics, and Roundup
- Low-level antibiotics causes weight gain in mice (and most mammals) – Aug 2014
- Antibiotics and Vitamin D are associated with many of the same diseases
- Antibiotic usage US map is very similar to obesity US map - June 2015
- Autism associated with low gut flora (due to antibiotics) – Mercola Oct 2014
Search VitaminDWiki for Acid Suppressive OR PPI 43 items as of April 2018
- Off Topic: Taking a PPI for GERD increases chance of death from heart disease by 2X– Aug 2015 - any age
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017 includes PPI
Note: Not in this study
- Infant Antibiotics upsets gut development
- Infant Antibiotics increases risk of later obesity
- Infant Antibiotic problems are reduced by both Probiotiics and Omega-3
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7 minute audio summary of this study can be downloaded at the bottom of this page
Importance Allergic diseases are prevalent in childhood. Early exposure to medications that can alter the microbiome, including acid-suppressive medications and antibiotics, may influence the likelihood of allergy.
Objective To determine whether there is an association between the use of acid-suppressive medications or antibiotics in the first 6 months of infancy and development of allergic diseases in early childhood.
Design, Setting, and Participants A retrospective cohort study was conducted in 792 130 children who were Department of Defense TRICARE beneficiaries with a birth medical record in the Military Health System database between October 1, 2001, and September 30, 2013, with continued enrollment from within 35 days of birth until at least age 1 year. Children who had an initial birth stay of greater than 7 days or were diagnosed with any of the outcome allergic conditions within the first 6 months of life were excluded from the study. Data analysis was performed from April 15, 2015, to January 4, 2018.
Exposures Exposures were defined as having any dispensed prescription for a histamine-2 receptor antagonist (H2RA), proton pump inhibitor (PPI), or antibiotic.
Main Outcomes and Measures The main outcome was allergic disease, defined as the presence of food allergy, anaphylaxis, asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, urticaria, contact dermatitis, medication allergy, or other allergy.
Results Of 792 130 children (395 215 [49.9%] girls) included for analysis, 60 209 (7.6%) were prescribed an H2RA, 13 687 (1.7%) were prescribed a PPI, and 131 708 (16.6%) were prescribed an antibiotic during the first 6 months of life. Data for each child were available for a median of 4.6 years. Adjusted hazard ratios (aHRs) in children prescribed H2RAs and PPIs, respectively, were 2.18 (95% CI, 2.04-2.33) and 2.59 (95% CI, 2.25-3.00) for food allergy, 1.70 (95% CI, 1.60-1.80) and 1.84 (95% CI, 1.56-2.17) for medication allergy, 1.51 (95% CI, 1.38-1.66) and 1.45 (95% CI, 1.22-1.73) for anaphylaxis, 1.50 (95% CI, 1.46-1.54) and 1.44 (95% CI, 1.36-1.52) for allergic rhinitis, and 1.25 (95% CI, 1.21-1.29) and 1.41 (95% CI, 1.31-1.52) for asthma. The aHRs after antibiotic prescription in the first 6 months of life were 2.09 (95% CI, 2.05-2.13) for asthma, 1.75 (95% CI, 1.72-1.78) for allergic rhinitis, 1.51 (95% CI, 1.38-1.66) for anaphylaxis, and 1.42 (95% CI, 1.34-1.50) for allergic conjunctivitis.
Conclusions and Relevance This study found associations between the use of acid-suppressive medications and antibiotics during the first 6 months of infancy and subsequent development of allergic disease. Acid-suppressive medications and antibiotics should be used during infancy only in situations of clear clinical benefit.
This study is described in NYT - April 2018
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