Impact of Parental Asthma, Prenatal Maternal Asthma Control and Vitamin D Status on Risk of Asthma and Recurrent Wheeze in 3-Year Old Children.
Clin Exp Allergy. 2018 Nov 21. doi: 10.1111/cea.13320. [Epub ahead of print]
Maternal Vitamin D Supplementation to Prevent Childhood Asthma = VDAART
- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Overview Asthma and Vitamin D
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
- Vitamin D supplements could halve risk of serious asthma attacks – Cochrane conclusion – Sept 2016
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Proof that Vitamin D Works 86 health problems prevented/treated as of May 2018
Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- All items in Breathing and Vitamin D
439 items includes Asthma, Pneunomia, RTI, TB, Allergy, COPD
Recent studies in Breathing and Intervention categories (give vitamin D and see what happens) in VitaminDWiki:
- Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
- Resulting childhood Asthma cut in half if 4,400 IU Vitamin D (5 ways to improve it) - RCT April 2023
- Several smoking problems treated by Vitamin D (bi-weekly, 50,000 IU) - RCT Dec 2021
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021
- Colds substantially reduced by Vitamin D or UV during military training – Jan 2021
- Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2021
- Upper Respiratory Tract Infections in adults reduced by just 400 IU of vitamin D – RCT Dec 2020
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019
- COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Childhood colds reduced 25 percent by weekly Vitamin D – RCT Jan 2019
- All asthma problems reduced after 1 year of Vitamin D – Nov 2017
- Asthma treated by daily 50,000 IU of Vitamin D – April 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
PDF is available free at Sci-Hub 10.1111/cea.13320
Mirzakhani H1, Carey VJ1, Zeiger R2, Bacharier LB3, O'Connor GT4, Schatz MX2, Laranjo N1, Weiss ST1,5, Litonjua AA6.
1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
2 Department of Allergy and Research and Evaluation, Kaiser Permanente Southern California Region, San Diego and Pasadena, California.
3 Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, Missouri.
4 Pulmonary Center, Department of Medicine, Boston Medical Center, Boston University, Boston, Massachusetts.
5 Partners Center for Personalized Medicine, Partners Health Care, Boston, MA.
6 Division of Pediatric Pulmonary Medicine, Dept of Pediatrics, Golisano Children's Hospital at Strong, U. of Rochester Medical Center, Rochester, NY.
While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma, and the role of maternal asthma control in pregnancy on the risk for asthma in the child.
We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk of asthma or recurrent wheeze in 3-year old children how prenatal and cord blood vitamin D status might affect this risk.
Data from 806 women, their partners (biologic fathers of the infant), and their children participated in the Vitamin D Antenatal Asthma Reduction Trail (VDAART, clinicaltrialsgov identification number NCT00920621) were used for this cohort analysis. The parental report of physician-diagnosed asthma or recurrent wheeze in offspring was the main outcome. Weibull regression models for interval-censored event times were used to estimate the main variables of interests and additional covariates on the outcome.
The highest risk was observed among children with both parents being asthmatic relative to non-asthmatic parents (aHR=2.30, 95%CI: 1.35-3.84), and less so if only the mother was asthmatic (aHR=1.70, 95%CI: 1.17-2.40). In the subset of children born to asthmatic mothers, the risk for asthma was higher in those who were born to mothers whose asthma was uncontrolled (aHR=1.60, 95%CI: 1.02-2.54). Children whose mothers had sufficient vitamin D status (25Hydroxyvitamin D≥30 ng/mL) at early and late pregnancy and had cord blood vitamin D sufficiency demonstrated a lower risk of asthma/recurrent wheeze than children who had insufficient vitamin D status at birth (aHR=0.47, 95%CI: 0.27-0.83).
CONCLUSION AND CLINICAL RELEVANCE:
Careful attention to maternal asthma control, monitoring vitamin D status and correcting insufficiency at early pregnancy and maintaining the sufficiency status throughout pregnancy have potential preventive roles in offspring asthma or recurrent wheezeAsthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
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