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Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018

Impact of Parental Asthma, Prenatal Maternal Asthma Control and Vitamin D Status on Risk of Asthma and Recurrent Wheeze in 3-Year Old Children.

Clin Exp Allergy. 2018 Nov 21. doi: 10.1111/cea.13320. [Epub ahead of print]

VitaminDWiki

Maternal Vitamin D Supplementation to Prevent Childhood Asthma = VDAART

Recent studies in Breathing and Intervention categories (give vitamin D and see what happens) in VitaminDWiki:

PDF is available free at Sci-Hub  10.1111/cea.13320

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Mirzakhani H1, Carey VJ1, Zeiger R2, Bacharier LB3, O'Connor GT4, Schatz MX2, Laranjo N1, Weiss ST1,5, Litonjua AA6.
1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
2 Department of Allergy and Research and Evaluation, Kaiser Permanente Southern California Region, San Diego and Pasadena, California.
3 Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, Missouri.
4 Pulmonary Center, Department of Medicine, Boston Medical Center, Boston University, Boston, Massachusetts.
5 Partners Center for Personalized Medicine, Partners Health Care, Boston, MA.
6 Division of Pediatric Pulmonary Medicine, Dept of Pediatrics, Golisano Children's Hospital at Strong, U. of Rochester Medical Center, Rochester, NY.

BACKGROUND:
While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma, and the role of maternal asthma control in pregnancy on the risk for asthma in the child.

OBJECTIVE:
We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk of asthma or recurrent wheeze in 3-year old children how prenatal and cord blood vitamin D status might affect this risk.

METHODS:
Data from 806 women, their partners (biologic fathers of the infant), and their children participated in the Vitamin D Antenatal Asthma Reduction Trail (VDAART, clinicaltrialsgov identification number NCT00920621) were used for this cohort analysis. The parental report of physician-diagnosed asthma or recurrent wheeze in offspring was the main outcome. Weibull regression models for interval-censored event times were used to estimate the main variables of interests and additional covariates on the outcome.

RESULTS:
The highest risk was observed among children with both parents being asthmatic relative to non-asthmatic parents (aHR=2.30, 95%CI: 1.35-3.84), and less so if only the mother was asthmatic (aHR=1.70, 95%CI: 1.17-2.40). In the subset of children born to asthmatic mothers, the risk for asthma was higher in those who were born to mothers whose asthma was uncontrolled (aHR=1.60, 95%CI: 1.02-2.54). Children whose mothers had sufficient vitamin D status (25Hydroxyvitamin D≥30 ng/mL) at early and late pregnancy and had cord blood vitamin D sufficiency demonstrated a lower risk of asthma/recurrent wheeze than children who had insufficient vitamin D status at birth (aHR=0.47, 95%CI: 0.27-0.83).

CONCLUSION AND CLINICAL RELEVANCE:
Careful attention to maternal asthma control, monitoring vitamin D status and correcting insufficiency at early pregnancy and maintaining the sufficiency status throughout pregnancy have potential preventive roles in offspring asthma or recurrent wheeze

Created by admin. Last Modification: Thursday November 22, 2018 15:21:38 GMT-0000 by admin. (Version 4)

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