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Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014

Vitamin D and the development of allergic disease: how important is it?

Clinical & Experimental Allergy DOI: 10.1111/cea.12430
Hooman Mirzakhani 1,2, Amal Al-Garawi 1,2, Scott T. Weiss 1,2,4 and Augusto A. Litonjua 1,2,3, augusto.litonjua at channing.harvard.edu
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
2Harvard Medical School, Boston, Massachusetts, United States of America
3Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
4Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America

Vitamin D has known effects on lung development and the immune system that may be important in the development, severity and course of allergic diseases (asthma, eczema and food allergy). Vitamin D deficiency is prevalent worldwide and may partly explain the increases in asthma and allergic diseases that have occurred over the last 50-60 years. In this review we explore past and current knowledge on the effect of vitamin D on lung development and immunomodulation and present the evidence of its role in allergic conditions. While there is growing observational and experimental evidence for the role of vitamin D, well-designed and well-powered clinical trials are needed to determine whether supplementation of vitamin D should be recommended in these disorders.

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