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Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015

Asthma exacerbations in children decrease by 60 percent with vitamin D supplementation – meta-analysis – 2015

1.7X increased risk of Asthma if low vitamin D - April 2015

Association between vitamin D deficiency and insufficiency and the risk of childhood asthma: evidence from a meta-analysis.
Int J Clin Exp Med. 2015 Apr 15;8(4):5699-706. eCollection 2015.
Man L1, Zhang Z2, Zhang M2, Zhang Y1, Li J3, Zheng N1, Cao Y1, Chi M1, Chao Y1, Huang Q1, Song C1, Xu B1.

OBJECTIVE: Whether vitamin D deficiency and insufficiency are associated with childhood asthma remains unclear. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin D deficiency and insufficiency and the risk of childhood asthma.

METHODS: Pertinent studies were identified by searching of PubMed and Web of Knowledge. The random effect model was used to combine the results. Meta-regression and subgroups analyses were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using Egger's regression asymmetry test.

RESULTS: Finally, 14 articles with 15 studies including 3424 cases for vitamin D deficiency and 9 articles with 10 studies including 2756 cases for vitamin D insufficiency were included in this meta-analysis. The relative risk (95% confidence interval) of childhood asthma risk for vitamin D deficiency was 1.684 (1.321-2.148), and the associations were significant in America and Europe. Significant association of childhood asthma between vitamin D insufficiency and childhood asthma risk was found overall [1.577 (1.230-2.023)] and the subgroups of America, Europe and Asia. No evidence of significant publication bias between vitamin D deficiency and insufficiency and childhood asthma risk were found.

CONCLUSIONS: Results from this meta-analysis suggested that vitamin D deficiency and insufficiency might increase the risk of childhood asthma.

PMID: 26131154

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60% Asthma reduction if take 500 - 2000 IU of vitamin D daily - Nov 2014

Efficacy of high-dose vitamin D in pediatric asthma: A systematic review and meta-analysis
J Asthma. 2014 Nov 3:1-29. [Epub ahead of print]
Pojsupap S1, Iliriani K, Sampaio TZ, O'Hearn K, Kin R, Kovesi T, Menon K, McNally JD.
Author information
1Division of Critical Care, Department of Pediatrics, Faculty of Medicine, University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, Canada.

Context: Observational studies have suggested a relationship between vitamin D status and asthma-related respiratory outcomes. The benefit of vitamin D supplementation for pulmonary function, symptoms and exacerbations is not well established.

Objective: To systematically review paediatric clinical trials investigating the role of vitamin D on asthma-related respiratory outcomes.

Data sources: MEDLINE, EMBASE and CENTRAL were searched January 2014. No date or language restrictions. Study selection: Clinical trials reporting asthma-related respiratory outcomes following vitamin D administration at a dose equal or greater than 500 IU per day were included and reviewed independently by two authors for full systematic review eligibility.

Data extraction: Two reviewers independently extracted and verified predefined data fields.

Results: We identified five studies that met study eligibility and assessed final data synthesis.
The median trial size was 48 participants (range 17-430) and the average daily dose of cholecalciferol ranged from 500 to 2,000 IU/day.
Overall study methodological quality was high, but some heterogeneity in population and vitamin D dosing regimen was evident.
Meta-analysis suggested a statistically significant reduction (RR 0.41, CI 0.27 to 0.63) in asthma exacerbation with vitamin D therapy.

Limitations: Due to variability in outcome selection and missing data, it was not possible to perform meta-analysis for pulmonary function testing and asthma symptom scores. Vitamin D-related adverse events were not considered in four of five papers.

Conclusions: Available evidence from this systematic review suggests that high dose vitamin D may prevent asthma exacerbation. This should be confirmed through larger well-designed randomized controlled trials.

PMID: 25365192

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