Can Vitamin D Supplementation in Addition to Asthma Controllers Improve Clinical Outcomes in Patients With Asthma?: A Meta-Analysis.
Medicine (Baltimore). 2015 Dec;94(50):e2185. doi: 10.1097/MD.0000000000002185.
Luo J1, Liu D, Liu CT.
\1From the Departments of Respiratory Medicine (JL, C-TL) and Critical Care Medicine (DL), West China School of Medicine and West China Hospital, Sichuan University, Chengdu, China.
- Overview Asthma and Vitamin D
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Proof that Vitamin D Works
Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
Breathing category starts with the following
- Search VitaminDWiki for "Respiratory Tract Infection" 482 items as of Sept 2017
- Search VitaminDWiki for Pneumoma 521 items as of Oct 2017
- Search VitaminDWiki for BRONCHITIS 314 items as of Sept 2018
- Search VitaminDWiki for ASTHMA in title 184 items - June 2018
- COPD Overview
- Search VitaminDWiki for Wheeze 1150 items as of Dec 2018
- Search VitaminDWiki for "air pollution" 554 items as of May 2018
- Cystic Fibrosis category listing has
34 items along with related searches
- Air Pollution reduces Vitamin D
Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
- Smoking reduces vitamin D
Supplementing with Vitamin D will improve the health of smokers and might decease craving
- Overviews at VitaminDWiki: Allergy Lung Cancer TB Asthma Influenza Colds and flu Pneumonia Respiratory infections
Effects of vitamin D on acute exacerbation, lung function, and fraction of exhaled nitric oxide (FeNO) in patients with asthma are controversial. We aim to further evaluate the roles of vitamin D supplementation in addition to asthma controllers in asthmatics. From 1946 to July 2015, we searched the PubMed, Embase, Medline, Cochrane Central Register of Controlled Trials, and ISI Web of Science using "Vitamin D," "Vit D," or "VitD" and "asthma," and manually reviewed the references listed in the identified articles. Randomized controlled trials which reported rate of asthma exacerbations and adverse events, forced expiratory volume in 1 s (FEV1, % of predicted value), FeNO, asthma control test (ACT), and serum 25-hydroxyvitamin D levels were eligible. We conducted the heterogeneities test and sensitivity analysis of the enrolled studies, and random-effects or fixed-effects model was applied to calculate risk ratio (RR) and mean difference for dichotomous and continuous data, respectively. Cochrane systematic review software Review Manager (RevMan) was used to test the hypothesis by Mann-Whitney U test, which were displayed in Forest plots. Seven trials with a total of 903 patients with asthma were pooled in our final studies. Except for asthma exacerbations (I2 = 81%, χ2 = 10.28, P = 0.006), we did not find statistical heterogeneity in outcome measures. The pooled RR of asthma exacerbation was 0.66 (95% confidence interval: 0.32-1.37), but without significant difference (z = 1.12, P = 0.26), neither was in FEV1 (z = 0.30, P = 0.77), FeNO (z = 0.28, P = 0.78), or ACT (z = 0.92, P = 0.36), although serum 25-hydroxyvitamin D was significantly increased (z = 6.16, P < 0.001). Vitamin D supplementation in addition to asthma controllers cannot decrease asthma exacerbation and FeNO, nor improve lung function and asthma symptoms, although it can be safely applied to increase serum 25-hydroxyvitamin D levels.
1974 visitors, last modified 10 Dec, 2016, URL:
- Air Pollution reduces Vitamin D