The Role of Vitamin D in Respiratory Allergies Prevention. Why the Effect Is So Difficult to Disentangle?
Nutrients. 2020 Jun 17;12(6):E1801. doi: 10.3390/nu12061801.
Hanna Sikorska-Szaflik 1, Barbara Sozańska 1
•dose and formulation of supplemented vitamin D
•duration and time of intervention (winter/summer)
•different laboratory methods to check serum vitamin D levels
•varied approach in defining outcomes (making a diagnose of allergic diseases)
•age of exposure (fetuses/children/adults)
•time spent outdoors
•lifestyle factors (smoking)
- Allergy - Overview
- Overview Asthma and Vitamin D
- Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014
- Vitamin D needed is proportional to weight - yet many studies use the same dose for all participants
- To get Vitamin D into their blood some people need a gut-friendly form of Vitamin D (or topical)
- Vitamin D metabolism requires Magnesium at 8 stages, but many people are Mg deficient
- Reasons for low response to vitamin D
- Some allergies need more than Vitamin D monotherapy
- Some allergies are due to low Vitamin D earlier in life
- Some allergies were the result of other causes
Asthma and allergic rhinitis are the most common chronic childhood diseases with an increasing prevalence worldwide. There is an urgent need to look for methods of preventing allergic diseases from an early age. The relationship between vitamin D status and allergic diseases has been discussed in several studies recently. 25-hydroxyvitamin D (25(OH)D) is suggested to affect the development and/or severity of asthma and allergic rhinitis. Observational studies have seemed to confirm that vitamin D deficiency may contribute to an increase in allergy and asthma. Following interventional studies, however, have yielded ambiguous results. In this review, we describe recent findings regarding 25(OH)D impact on allergic diseases and provide a systematic analysis of the causes of great variability of the achieved results in different studies.