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Vitamin D blocks Vitamins K1, Vitamin A – 2015


Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption

Food Chemistry 172 (2015) 155-160 http://dx.doi.org/10.1016Zj.foodchem.2014.09.0210308-8146
a,b'c, Amelie Dhaussyd, Alain Huertas d,
a INRA, UMR1260 ‘‘Nutrition, Obesity and Risk of Thrombosis'', F-13385 Marseille, France b INSERM, UMR U1062, F-13385 Marseille, France cAix-Marseille Universite, Faculte de Medecine, F-13385 Marseille, France d Lesieur, F-92600 Asnieres-sur-Seine, France


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High dose Vitamin A (black bar) reduces the uptake of Vitamin D


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High dose Vitamin D (black bar) reduces by half the uptake of Vitamin K


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All of the tall bars are part of the "small" intestine (22 feet in length)


The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites. We then investigated the interactions between FSVs during their uptake by Caco-2 cells. Our data show that vitamin A was mostly absorbed in the mouse proximal intestine, while vitamin D was absorbed in the median intestine, and vitamin E and K in the distal intestine. Significant competitive interactions for uptake were then elucidated among vitamin D, E and K, supporting the hypothesis of common absorption pathways. Vitamin A also significantly decreased the uptake of the other FSVs but, conversely, its uptake was not impaired by vitamins D and K and even promoted by vitamin E. These results should be taken into account, especially for supplement formulation, to optimise FSV absorption.


192 studies cited this as of Dec 2023

Google Scholar

  • Impact of pulses, starches and meat on vitamin D and K postprandial responses in mice - Feb 2023 https://doi.org/10.1016/j.foodchem.2022.133922
    • Chickpeas and meat are associated with decreased vitamin K compared to potatoes (40%? 90%?)
  • Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility - 2015
  • Intestinal absorption of vitamin D: a systematic review - 2018
  • Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins - 2019
  • Vitamin D microencapsulation and fortification: Trends and technologies - 2020  In VitaminDWiki: Fortification with Vitamin D

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Attached files

ID Name Comment Uploaded Size Downloads
7675 K blocked by High D.jpg admin 15 Jan, 2017 17.60 Kb 4430
7674 High A blocks D.jpg admin 15 Jan, 2017 20.35 Kb 4750
7673 D vs intestine.jpg admin 15 Jan, 2017 16.64 Kb 4240
7672 Fat-soluble vitamin intestinal absorption.pdf admin 15 Jan, 2017 487.85 Kb 1864