The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System.
Int J Endocrinol. 2017;2017:3206240. doi: 10.1155/2017/3206240. Epub 2017 Aug 23.
Zittermann A1.
Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.
Author includes studies showing problems
with annual and quarterly dosing
Must adjust co-factors
(especially > Magnesium and < Calcium)
- Vitamin D Cofactors in a nutshell
- Review of vitamin D interaction with drugs – Jan 2014
Vitamin D increases the potency of some drugs - which can be deadly with Chemo drugs - Does too much Vitamin D cause problems – possible for allergies, maybe for falls – Review June 2016
- Even if a J curve exists, it is 50X better to give vitamin D than not give it – May 2013
- Is 50 ng of vitamin D too high, just right, or not enough
- Is too much vitamin D bad – possible causes and cures
- Falls and vitamin D – another poor study – RCT Oct 2017
Download the PDF from VitaminDWiki
This narrative review summarizes beneficial and harmful vitamin D effects on the musculoskeletal and cardiovascular system. Special attention is paid to the dose-response relationship of vitamin D with clinical outcomes. In infants and adults, the risk of musculoskeletal diseases is highest at circulating 25-hydroxyvitamin D (25OHD) concentrations below 25 nmol/L and is low if 40-60 nmol/L are achieved. However, evidence is also accumulating that in elderly people the risk of falls and fractures increases again at circulating 25OHD levels > 100 nmol/L. Cohort studies report a progressive increase in cardiovascular disease (CVD) events at 25OHD levels < 50 nmol/L. Nevertheless, meta-analyses of randomized controlled trials suggest only small beneficial effects of vitamin D supplements on surrogate parameters of CVD risk and no reduction in CVD events. Evidence is accumulating for adverse vitamin D effects on CVD outcomes at 25OHD levels > 100 nmol/L, but the threshold may be influenced by the level of physical activity. In conclusion, dose-response relationships indicate deleterious effects on the musculoskeletal system and probably on the cardiovascular system at circulating 25OHD levels < 40-60 nmol/L and >100 nmol/L. Future studies should focus on populations with 25OHD levels < 40 nmol/L and should avoid vitamin D doses achieving 25OHD levels > 100 nmol/L.
PMID: 28912809 PMCID: PMC5587949 DOI: 10.1155/2017/3206240