Intervention = Give Vitamin D to a portion of study participants and see what happens
Typically
- Intervene with the group: one dose size, but sometimes intervene while varying the dose size
- perhaps such that each individual exceeds the desired blood level (say 40 ng)
- Group size: 50 to 500 people, but can be ~ 100,000 individuals ( Turkey- Rickets )
- Vitamin D3, but sometimes an activated form ( Calcidiol, or Calcitriol)
- Disease treatment, but sometimes disease prevention
- Just Vitamin D (monotherapy), even though cofactors are very important, especially if > 4,000 IU
Note - some interventions use loading doses to restore levels quickly (days or weeks instead of months)
Which also includes small single dose of vitamin D - say 100,000 IU
Not listed - Trials which clearly used too little vitamin D or too short of period
The many reasons why Vitamin D trials fail – Oct 2020
US Clinical Trials with Vit D Intervention new since Jan 2018 453 as of Oct 2020
See also
Some Intervention Trials which used Vitamin D a count of some of the trials- by health problem
Loading dose for Vitamin D
Proof that Vitamin D Works
Supplementing Vitamin D
Items in category Meta-analysis
Intervention - Vitamin D by date instead of by health problem
Studies in VitaminDWiki
| Year | Randomized Controlled Trials | Interventions | Meta- analyses |
| 2017 | - | 48 | 52 |
| 2016 | - | 51 | 40 |
| 2015 | 69 | 82 | 35 |
| 2014 | 64 | 63 | 48 |
| 2013 | 81 | 63 | 37 |
| 2012 | 41 | 38 | 39 |
Note: Govt recommendations in 2015 often ignored data after 2011
INTERVENTION categories include
- Most-visited 20 pages in Intervention category in VitaminDWiki
- Intervention AND Autism
- Intervention AND Autoimmune
- Intervention AND Bone (see also Rickets)
- Intervention AND Breathing
- Intervention AND Cancer
- Intervention AND Cancer - Breast
- Intervention AND Cancer - Skin
- Intervention AND Cardiovascular
- Intervention AND Cognitive
- Intervention AND Dental
- Intervention AND Depression
- Intervention AND Diabetes (see also Metabolic Syndrome)
- Intervention AND Fertility/Sperm
- Intervention AND Falls/Fractures
- Intervention AND Gut
- Intervention AND Headache
- Intervention AND Hypertension
- Intervention AND Immune
- Intervention AND Inflammation
- Intervention AND Infant/Child (see also Rickets)
- Intervention AND Kidney
- Intervention AND Liver
- Intervention AND Meta-analysis
- Intervention AND Metabolic Syndrome (see also Diabetes)
- Intervention AND Mortality
- Intervention AND Multiple Sclerosis (see also Autoimmune)
- Intervention AND Obesity (weight)
- Intervention AND Optimum
- Intervention AND Osteoporosis
- Intervention AND Pain
- Intervention AND Parkinson's
- Intervention AND Pregnancy
- Intervention AND Psorasis (see also Skin)
- Intervention AND Rheumatoid Arthritis
- Intervention AND Rickets
- Intervention AND Seniors
- Intervention AND Skin
- Intervention AND Skin - Dark
- Intervention AND Sleep
- Intervention AND Sports
- Intervention AND Stroke
- Intervention AND TB
- Intervention AND Thyroid/Parathyroid
- Intervention AND Trauma/surgery
- Intervention AND Youth (see also Infant-Child)
- Intervention AND Women (see also Pregnancy)
- Intervention AND Loading Dose
- Intervention - sorted by date
Most-visited 20 pages in Intervention category in VitaminDWiki
Intervention AND Autism
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Autistics have half of the response to Vitamin D (perhaps poor genes) – RCT Oct 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
Intervention AND Autoimmune
- Vitamin D not help when not give enough (Graves Disease in this case – 26 ng) – Jan 2020
- Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019
- Hives treatment augmented by 60,000 IU Vitamin D weekly – RCT June 2015
- 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Chronic Hives treated by Vitamin D - many studies
- Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012
Intervention AND Bone (see also Rickets)
- Bones of white children not helped by 1,000 IU of vitamin D (Northern latitudes) – RCT Sept 2018
- Vitamin D and Calcium do not increase bone density (also need exercise, Mg, K2, protein etc.) – RCT Aug 2019
- Fetal bones helped a bit by 1,000 IU of vitamin D – RCT Feb 2019
- Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017
- Bone mineral density somewhat better with 3750 IU vs 600 IU Vitamin D (1 year, with Calcium) – RCT March 2017
- Leg bone (tibia) grew thicker with 4,000 IU of vitamin D and Calcium – RCT Aug 2016
- More calcium in bones in those teenage girls getting 2,000 IUs daily – RCT Jan 2016
- People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014
- Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose – July 2014
- Hip bone loss stopped with 1000 IU of vitamin D, while 400 IU similar to placebo – RCT April 2013
- Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013
- 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
- Statin-induced Myalgias corrected with 100000 weekly Vitamin D2
Intervention AND Breathing
- Asthma treated by monthly 100,000 IU of Vitamin D if person had very low levels – RCT Feb 2021
- Colds substantially reduced by Vitamin D or UV during military training – Jan 2021
- Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2020
- Upper Respiratory Tract Infections in adults reduced by just 400 IU of vitamin D – RCT Dec 2020
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019
- COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Childhood colds reduced 25 percent by weekly Vitamin D – RCT Jan 2019
- All asthma problems reduced after 1 year of Vitamin D – Nov 2017
- Asthma treated by daily 50,000 IU of Vitamin D – April 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls – Nov 2016
- RTI – Feel much better if increase vitamin D level above 40 ng (4000 IU) – RCT Sept 2015
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015
- Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015
- Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015
- Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
- Respiratory infections cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT April 2015
- Respiratory diseases helped by vitamin D if initially have low level – RCT review Jan 2015
- COPD reduced by vitamin D taken once every 60 days – RCT Dec 2014
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- Allergy to House dust mite greatly reduced by adding just 600 IU of vitamin D – RCT Nov 2014
- Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013
- COPD Overview
- Respiratory infections reduced by 63 percent with 4000 IU vitamin D daily - RCT Dec 2012
- Just 300 IU daily of vitamin D reduced respiratory infections by 50% – RCT Aug 2012
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 100000 IU vitamin D monthly helps COPD patients – 3 RCT
Intervention AND Cancer
- 2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 1.7X (normal weight) – VITAL RCT Nov 2020
- Prostate Cancer treatment (Vitamin D, Omega-3, Tumeric) RCT ending Dec 2018
- Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016
- Mayo clinic starting Cancer RCT using grossly inadequate 2,000 IU of vitamin D – Sept 2013
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
- Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011
Intervention AND Cancer - Breast
- Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Perhaps Breast Cancer tumors can be reduced by 7 weeks of 50,000 IU Vitamin D – 2023
- Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016
- Breast Cancer reduced 20 percent by just 400 IU of vitamin D plus Calcium – 2011
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
Intervention AND Cancer - Skin
Intervention AND Cardiovascular
- 50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014
- 50,000 IU of Vitamin D weekly for 9 weeks did not improve CVD – Aug 2018
- Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT May 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017
- Heart Failure not helped by Vitamin D (several strange things about the trial) – RCT May 2017
- Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
- Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D – May 2015
- Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014
- 1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT Oct 2014
- Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014
- Hearts responded to stress better after 5,000 IU of vitamin D for a month - March 2014
- More blood was pumped by those getting 800,000 IU of vitamin D after heart failure – RCT Oct 2013
- Chronic Heart Failure helped with 2,000 IU of vitamin D (PRA reduced) – RCT June 2013
- 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013
- Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
Intervention AND Cognitive
- Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
- Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT Dec 2020
- Methadone cognition improved by 50,000 IU of vitamin D every 2 weeks – RCT May 2019
- Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019
- Cognitive function of adult women improved in 3 months of 50K IU weekly Vitamin D – Jan 2019
- Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018
- Cognition improved a tiny amount with 400 IU of vitamin D (not a surprise) – RCT Oct 2018
- 9,000 dollar prize for RCT which found cognition improved after taking 4,000 IU of Vitamin D for 18 weeks – May 2018
- Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Mental health intervention trials using enough vitamin D for long enough found benefits – Jan 2017
- Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT Jan 2017
- Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015
- 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
- Better memory if take lots of vitamin D (senior rats) – May 2015
- Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Age-related cognitive decline in rats mitigated by Vitamin D intervention – RCT Oct 2012
Intervention AND Dental
- Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019
- Severe tooth decay in children unless supplemented with Vitamin D drops – Oct 2013
- Gingivitis inflammation reduced 88 percent with 2000 IU of vitamin D – RCT Jan 2013
- Dental health improved with more than 800 IU of vitamin D – June 2013
- UVB added in classroom reduced cavities, increased height, increased academics. etc
- Dental caries cut in half by vitamin D, review of 24 old clinical trials – Nov 2012
Intervention AND Depression
- Depression in psychiatric youths reduced 28 percent after just 1 month of vitamin D – RCT Feb 2020
- Yet another study confirms Depression is treated by weekly Vitamin D – RCT Dec 2019
- Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019
- Vitamin D - no cure for depression (when you use only 1200 IU) – Aug 2019
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Women had better sexual desire, orgasm and satisfaction after Vitamin D supplementation – Feb 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013
- Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013
- 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
Intervention AND Diabetes (see also Metabolic Syndrome)
- Little Vitamin D benefit if not achieve a good level (T1D in this cases) – Jan 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- Diabetes not helped by increasing Vitamin D levels to 20 ng (proven again) – RCT March 2020
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Diabetes helped by 5,000 IU of Vitamin D – RCT Sept 2019
- 100,000 IU of Vitamin D3 or D2 given monthly for 4 months to diabetics– RCT Dec 2019
- Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways) June 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Diabetes treated by vitamin D when levels exceeded 61 ng – Sept 2015
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Diabetes decreased in aged mice supplemented with vitamin D – April 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Recent Diabetics treated by supplementation which achieved 60 ng of vitamin D – RCT Sept 2014
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
- Prediabetics 60 percent less likely to become diabetic if given some vitamin D – Jan 2014
- Diabetes prevention RCT kicked off: adding 4,000 IU vitamin D - Oct 2013
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Insulin improvement in obese teens with 4000 IU of vitamin D – RCT Feb 2013
- Insulin resistance helped with 50000 IU of vitamin D weekly – Feb 2013
- Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013
- Prediabetics not helped by 50,000 IU of vitamin D weekly and Calcium– Jan 2013
- 140,000 IU vitamin D monthly reduced probability of diabetes – Nov 2011
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Overview Diabetes and vitamin D
Intervention AND Fertility/Sperm
- In Vitro Fertilization clinical trial using 50,000 IU of Vitamin D bi-weekly – Dec 2024
- Sperm not improved enough by Vitamin D - 50,000 IU weekly for 8 weeks - RCT Aug 2020
- Women had better sexual desire, orgasm and satisfaction after Vitamin D supplementation – Feb 2018
- Testosterone and erectile function increased after vitamin D supplementation – Jan 2018
- Birth rates doubled with Vitamin D - 300,000 loading dose for men – RCT Nov 2017
- Increased Testosterone and Erectile function, decreased weight with Vitamin D – March 2017
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
Intervention AND Falls/Fractures
- Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls – Oct 2020
- Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019
- Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018
- Fell more often with higher doses of vitamin D (not statistically significant) – Oct 2017
- Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017
- Probably Fractures of the Tibia can be healed with 100,000 IU of vitamin D weekly – RCT 2023
- Perhaps fewer bone non-unions with 100,000 IU weekly of vitamin D – RCT 2018
- 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017
- Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017
- Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls – Nov 2016
- Elderly falls reduced 3.6 times by 900 IU of vitamin D and simple exercise – RCT Nov 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- 2X fewer Senior falls in group getting 100,000 IU vitamin D monthly via Meals-on-Wheels – RCT Aug 2015
- Rate of injuries from falls cut in half by just 800 IU of vitamin D and exercise – RCT May 2015
- Seniors need at least 4,000 IU vitamin D, no test needed – Consensus Jan 2014
- Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010
- Hip fracture reduced 38 percent with Calcium and just 400 IU of vitamin D – RCT Feb 2013
- Hip bone loss stopped with 1000 IU of vitamin D, while 400 IU similar to placebo – RCT April 2013
- Vertigo treated by Vitamin D - many studies
- 39% fewer falls with 2000 IU than 800 IU – RCT June 2010
Intervention AND Gut
- Diverticular disease:12X reduction if low Vitamin D and given 100,000 IU monthly – RCT Aug 2020
- Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019
- Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Vitamin D changed microbiota in gut and airway, might reduce cystic fibrosis – RCT Nov 2017
- Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017
- Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016
- IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016
- IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015
- Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015
- Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015
- Irritable Bowel Syndrome - can it be treated by 3000 IU of vitamin D - RCT Feb 2014
- Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013
- Crohn’s helped by 5000 IU vitamin D – April 2013
Intervention AND Headache
- Migraines in youths with low Vitamin D wonderfully treated by Vitamin D – June 2019
- Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018
- Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015
- Childhood migraine in Vitamin D deficient children reduced 6X by addition of daily 5,000 IU and amitriptyline – April 2014
- Cluster headaches substantially reduced by 10,000 IU of Vitamin D in 80 percent of people
Intervention AND Hypertension
- Pulmonary Hypertension deaths prevented by 80 ng of Vitamin D (in rats) – July 2017
- Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018
- Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- Pulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016
- Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016
- 2000 IU of vitamin D for just 2 weeks helped in many ways – RCT June 2016
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- Arterial stiffness reduced by a single dose of 100,000 IU of vitamin D – RCT Dec 2014
- Hypertension not reduced by adding vitamin D to patients who had enough vitamin D – RCT June 2014
- Hypertention (both systolic and diastolic) reduced with 2,000 IU of vitamin D – RCT June 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- 3000 IU reduced hypertension for the vitamin D insufficient – RCT Aug 2012
- Hypertension reduced 6.8 mmHg with 3,000 IU of vitamin D daily – RCT May 2012
- Systolic blood pressure reduced by vitamin D (many studies)
Intervention AND Immune
- Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021
- Sublingual Vitamin D sometimes is better than tablet – April 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Respiratory infections cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
- T-cells increased with monthly doses of 140,000 IU vitamin D – April 2014
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013
- Middle ear infection (Otitis Media) and Vitamin D – many studies
- Viral infection reduced 90 percent with 2000 IU of vitamin D – Dec 2010
- Yet again - more than 10000 IU of vitamin D treats MS – July 2011
Intervention AND Inflammation
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- UTI associated with low Vitamin D, treated by Vit. D, many UTI now resistant to antibiotics
- Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
- Anti-inflamatory cytokines increased when vitamin D levels were raised above 30 ng – RCT Feb 2015
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT Dec 2013
- Gingivitis inflammation reduced 88 percent with 2000 IU of vitamin D – RCT Jan 2013
- 4000 IU vitamin D daily for just 5 days reduced inflammation after heart attack – RCT Jan 2013
- Atopic dermatitis dramatically reduced in Iran with 1600 IU of vitamin D – RCT March 2012
- Vitamin D reduces sepsis
Intervention AND Infant/Child (see also Rickets)
- Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020
- Toddlers with more than 48 ng of vitamin D weighted less and were thinner – RCT Dec 2020
- 6,400 IU of Vitamin D is safe and effective during breastfeeding – RCT Dec, 2020
- Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Bones of white children not helped by 1,000 IU of vitamin D (Northern latitudes) – RCT Sept 2018
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- Tic disorder reduced by Vitamin D supplementation – Aug 2019
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- 400 IU of Vitamin D in food provided virtually no benefit to children - March 2018
- Children need 2000 IU of Vitamin D (India) - RCT May 2019
- Preterm babies have low vitamin D, but recover in 6 weeks with 800 IU supplementation – Jan 2019
- 1200 IU vs 400 IU of vitamin D did not improve bone health or immunity of children who were sufficient – RCT July 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- 400 IU of Vitamin D provided no benefit to children (not a surprise) – RCT March 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Preemies getting 800 IU of vitamin D were 3X less likely to have low bone density 4 weeks later – RCT Oct 2017
- Preemies need 1,000 IU of vitamin D – RCT Sept 2017
- Fatty liver disease in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Breastfeeding mothers and Vitamin D: supplement only themselves usually, 4 out of 10 used monthly rather than daily – Jan 2017
- Premature infants (30 weeks) who got 800-1000 IU of vitamin D were much healthier – March 2017
- Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016
- Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016
- Monthly 120,000 IU of Vitamin D during lactation worked well - May 2016
- Infant infection reduced by half with vitamin D supplementation – RCT May 2016
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Vitamin D improved child muscle mass even without varying dose with weight – RCT Feb 2016
- Breastfeeding mother getting 6400 IU of Vitamin D is similar to infant getting 400 IU – RCT Sept 2015
- Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
- Breast-feeding mothers need 2000 IU of vitamin D to get infants to even 12 ng – July 2015
- 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
- Growing pains reduced 57 percent by vitamin D therapy – May 2015
- T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015
- 50,000 IU Vitamin D one time after birth helped – RCT Jan 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- 2000 IU vitamin D during pregnancy and 800 IU to infant resulted in less use of antibiotics – RCT April 2014
- Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- 800 IU vitamin D for infant and 2000 IU for mother is good, not great – RCT Dec 2013
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
Intervention AND Kidney
- 1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021
- Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021
- Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol – Dec 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017
- Kidney disease helped by active or high dose Vitamin D - Feb 2014
- Peritoneal Dialysis nicely treated by active vitamin D – July 2013
- 7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease – July 2012
- Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT Aug 2012
- Overview Kidney and vitamin D
Intervention AND Liver
- NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018
- Alcoholic liver cirrhosis treated by 1,000 IU of vitamin D – July 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018
- Fatty liver disease in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016
- Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014
- 400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015
- Vitamin D prevents Hepatitis-C and helps treat it (many studies)
Intervention AND Meta-analysis
- RCTs probably not the future gold standard - CDC former head – July 2017
- Overview of Vitamin D Meta-analysis and RCT for Caucasians - July 2017
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Example of a vitamin D meta-analysis which ignored the data – June 2012
- Vitamin D and omega-3 are the only supplements which show benefit in meta-analysis – Jan 2012
Intervention AND Metabolic Syndrome (see also Diabetes)
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Metabolic Syndrome risk reduced 44 percent when vitamin D levels increased by 30 nanograms – Aug 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
Intervention AND Mortality
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- 6 percent less likely to die by taking just a little vitamin D for 3 plus years – RCT Dec 2013
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Should increase life expectancy by 2 years if double vitamin D levels – July 2011
Intervention AND Multiple Sclerosis (see also Autoimmune)
- 53 Multiple Sclerosis patients somewhat helped by 10,000 IU of vitamin D (vs, 30,000 virtually cured by 10X as much) – Jan 2020
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis Relapsing-Remitting rate reduced 30 percent by addition of 14,000 IU vitamin D daily – RCT Nov 2016
- Multiple sclerosis helped some by 10,000 IU of vitamin D daily avg. for 3 months – RCT Sept 2016
- Vitamin D has already cleared 100 percent of lesions from over 1,000 MS patients in Brazil
- Dr. Coimbra explains his treatment with high dose vitamin D for multiple sclerosis – Feb 2015
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013
- Optic neuritis progession into Multiple Sclerosis reduced 68 percent by 50,000 IU of vitamin D weekly
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012
- Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012
- MS helped by average daily 2800 IU vitamin D – RCT Aug 2012
- CureTogether Vitamin D symptoms, treatments, and causes
- Yet again - more than 10000 IU of vitamin D treats MS – July 2011
- Overview MS and vitamin D
Intervention AND Obesity (weight)
- Weight loss on low-calorie diet: 7 lbs more lost if got lots of Vitamin D – June 2021
- Overweight elderly respond well to 3600 IU Vitamin D daily for a year – RCT May 2021
- Little weight loss in obese children from very small amount of vitamin D (1200 IU) – RCT April 2020
- 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
- 2.3 X more weight loss in those who had low vitamin D levels and took some – Dec 2019
- Obese lost 3X more weight with Vitamin D - July 2018
- Severely Obese not helped much by 50,000 IU of vitamin D weekly for 8 weeks – RCT June 2019
- Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks – May 2019
- Obese responded to weekly vitamin D better than non-obese – RCT March 2018
- Daily, monthly Vitamin D had similar great benefits, more than 6 months needed – RCT Dec 2018
- Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs
- Lost 19 lbs more if add vitamin D to calorie restriction and walking program– July 2018
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Response by obese to weekly 50,000 IU of Vitamin D – May 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017
- Fatty liver disease in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Increased Testosterone and Erectile function, decreased weight with Vitamin D – March 2017
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015
- 24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT Feb 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014
- 50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013
- 50,000 IU vitamin D 1-3 times per week helped obese patients in rehab. – May 2013
- Obesity not reduced with 7,000 IU vitamin D daily – April 2013
- Higher BMI decreased response to 700 IU vitamin D – RCT 2008
- Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013
- 7000 IU vitamin D was not enough to reduce obese tissue – Jan 2013
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
Intervention AND Optimum
- 50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021
- Vitamin D RCT using 100,000 IU monthly for a variety of health problems – results of ViDA due in 2016
- Vitamin D supplementation improved quality of life – Aug 2015
- 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013
- Pure North (Calgary) improves health by raising vitamin D to 60 ng
- Sleep disorders cured by 60-80 ng of vitamin D and some B vitamins – March 2013
- Cluster headaches substantially reduced by 10,000 IU of Vitamin D in 80 percent of people
Intervention AND Osteoporosis
Intervention AND Pain
- Chronic pain greatly reduced by 2 dollars of Vitamin D – May 2021
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Dysmenorrhea substantially reduced by Ginger, just 1,000 IU Vitamin D also helped – RCT Nov 2019
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Growing pains reduced 57 percent by vitamin D therapy – May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015
- Pain reduced when enough vitamin D was given – review March 2015
- Less use of musculoskeletal pain drugs if get vitamin D – Feb 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014
- 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014
- Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014
- Quality of Life
- Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013
- 150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012
- Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
- Menstrual Pain reduced by vitamin D – RCT 2012, 2014, 2016
- Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012
Intervention AND Parkinson's
Intervention AND Pregnancy
- 6,400 IU of Vitamin D is safe and effective during breastfeeding – RCT Dec, 2020
- Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU – April 2020
- Massive improvement in vaginal microbiome during pregnancy with Vitamin D – March 2019
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Fetal bones helped a bit by 1,000 IU of vitamin D – RCT Feb 2019
- Adding 1,000 IU vitamin D while pregnant did not help much (no surprise) – RCT Jan 2019
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
- 300,000 IU of Vitamin D is not enough during pregnancy – RCT May 2018
- Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Monthly 120,000 IU Vitamin D plus daily Calcium was great during pregnancies – RCT Sept 2017
- Preterm birth rate reduced by vitamin D – 78 percent if non-white, 39 percent if white – July 2017
- 1,000 IU of Vitamin D while pregnant helped a little bit (4,000 IU helps a lot) – RCT Dec 2016
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- Only a select group of women will get a modest benefit from 800 IU of vitamin D – Jan 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- 3,800 IU Vitamin D during pregnancy did not help much – RCT Jan 2017
- 50,000 IU of vitamin D for 8 weeks of pregnancy raised most above 30 nanograms - RCT Jan 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- Pregnancy – adding 35,000 IU Vitamin D weekly was nice, but not enough – RCT April 2016
- Vitamin D once during pregnancy reduced infant health care costs (300 times ROI) – RCT Dec 2015
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Preterm birth rate reduced 57 percent by Vitamin D – Nov 2015
- Pregnancy supplemented with 2,000 IU vitamin D got most infants to more than 12 nanograms – Aug 2015
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- Clinical trials for pregnancy with Vitamin D intervention – 51 as of Sept 2015
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- 4,000 IU raised vitamin D levels during pregnancy – July 2014
- Pregnant mothers in Quatar needed more than weekly 50,000 IU Vitamin D – Nov 2013
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- Pregnancy helped by single dose of 60,000 IU of Vitamin D – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Improved births with 2,000 IU vitamin D during pregnancy in India - RCT Feb 2015
- 50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015
- Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT Nov 2014
- 2000 IU vitamin D during pregnancy and 800 IU to infant resulted in less use of antibiotics – RCT April 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- 5,000 IU Vitamin D was not enough to reduce preeclampsia but did help future infant – RCT April 2014
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
- Vitamin D intervention for 8 weeks of pregnancy: infants taller, heavier and bigger heads – RCT Oct 2013
- Prenatal Vitamin D (35,000 weekly, 3rd trimester) resulted in 1 cm taller infants at age 1 year – RCT Aug 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
Intervention AND Psorasis (see also Skin)
Intervention AND Rheumatoid Arthritis
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Just 500 IU of vitamin D helped reduce rheumatoid arthritis pain - RCT Oct 2011
Intervention AND Rickets
Intervention AND Seniors
- Overweight elderly respond well to 3600 IU Vitamin D daily for a year – RCT May 2021
- Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2020
- Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls – Oct 2020
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Physical performance of black senior women not improved with 30 ng of Vitamin D – RCT Nov 2018
- Senior quality of life not helped by 800 IU of Vitamin D (not nearly enough) – RCT Oct 2018
- Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018
- Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT Feb 2018
- Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017
- Nursing home residents need Vitamin D 4,000 IU daily or 50,000 IU weekly – Jan 2016
- Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – 2015, 2016
- Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015
- 800 IU vitamin D in capsule form (but not drops) helped nursing home residents – Sept 2014
- 5000 IU of vitamin D in daily bread resulted in 50 ng and improved quality of life– May 2014
- Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013
- Muscle increased 17 percent in vitamin D insufficient elderly getting 4,000 IU for 4 months – RCT Oct 2013
- 1600 IU vitamin D was enough to get all (white, non-obese) elderly to 20 ng – RCT Dec 2012
- Vertigo treated by Vitamin D - many studies
- 5000 IU vitamin D3 added daily to bread raised blood levels to 50 ng – 2009
Intervention AND Skin
- Sunburning reduced by 200,000 IU of Vitamin D – RCT April 2017
- Eczema (Atopic Dermatitis) treated by 1600 IU of vitamin D – meta-analysis Dec 2016
- Warts eliminated by vitamin D injections
- Atopic Dermatitis (Eczema) in Mongolian children reduced with 1,000 IU of vitamin D – RCT Oct 2014
- Skin damaged by sun helped by vitamin D supplementation - pilot study April 2015
- Atopic dermatitis dramatically reduced in Iran with 1600 IU of vitamin D – RCT March 2012
Intervention AND Skin - Dark
- Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018
- Physical performance of black senior women not improved with 30 ng of Vitamin D – RCT Nov 2018
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Less response to 800 IU of Vitamin D by Africans than natives in Finland – RCT March 2018
- Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies
- Monthly vitamin D (120,000 IU) got most overweight African Americans about 35 ng – RCT July 2015
- Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D – May 2015
- Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose – July 2014
- Many healthy African Americans got above 33 ng with 4,000 IU of vitamin D – RCT March 2014
- Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT Dec 2013
- 150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012
- 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
Intervention AND Sleep
- Sleeps disorders nicely treated by Vitamin D (50,000 IU bi-weekly) – RCT May 2017
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Sleep disorders cured by 60-80 ng of vitamin D and some B vitamins – March 2013
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
Intervention AND Sports
- 6,000 IU of vitamin D for 6 weeks helped soccer players somewhat – May 2020
- Only 1 NCAA basketball player getting 10,000 IU vitamin D daily achieved 50 ng goal – Jan 2020
- College swimmers helped by daily 5,000 IU of Vitamin D in the fall – RCT Feb 2020
- 4,000 IU of vitamin D for 1 month does not help (muscles in this case) – RCT Jan 2020
- Muscles not improved by just Vitamin D weekly (also need exercise) – Dec 2019
- Athletes helped by weekly 50,000 IU Vitamin D – RCT Aug 2019
- Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018
- Taekwondo athletes helped by just 1 month of Vitamin D (longer would be better) - RCT May 2018
- Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT Feb 2018
- Elite Athletes do well with weekly 35,000 IU of Vitamin D – RCT Feb 2017
- 2000 IU of vitamin D for just 2 weeks helped in many ways – RCT June 2016
- Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015
- Athletic performance and recovery benefits of Vitamin D (4000-5000 IU and Vitamin K) – Aug 2015
- Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015
- People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014
- Fewer injuries and higher ballet jumps with 2,000 IU of vitamin D – April 2013
- Collegiate Swimmers getting 4000 IU of vitamin D had fewer injuries – March 2013
- Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013
- Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010
Intervention AND Stroke
- Stroke patients getting weekly 50,000 IU Vitamin D did better – trial March 2021
- Stroke not prevented by just 2,000 IU of vitamin D plus 840 mg Omega-3 (VITAL) – Feb 2020
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
Intervention AND TB
- TB not treated by average daily 10,000 IU of vitamin D (previous RCTs disagree) – RCT Sept 2017
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT April 2016
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Tuberculosis not treated by lots of vitamin D for 16 weeks – RCT Sept 2015
- Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013
- TB treatment helped with Vitamin D – RCT Sept 2012
- Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT Aug 2012
- Overview Tuberculosis and Vitamin D
- Evaluating the vitamin D evidence - Heaney Dec 2010
Intervention AND Thyroid/Parathyroid
- Half as many problems if take Vitamin D (300,000 IU) before thyroid surgery – RCT Jan 2021
- Vitamin D not help when not give enough (Graves Disease in this case – 26 ng) – Jan 2020
- Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019
- Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
- 2800 IU of vitamin D before and after parathyroid surgery helped a lot – RCT Jan 2014
- 50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism – Jan 2013
Intervention AND Trauma/surgery
- Half as many problems if take Vitamin D (300,000 IU) before thyroid surgery – RCT Jan 2021
- Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT Dec 2020
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Surgeries outcomes far better if daily 50,000 IU of vitamin D for a week – Oct 2018
- Knee replacement not helped by 2,000 IU of vitamin D (both too late and too little) – RCT July 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- 18 fewer hospital days if given 500,000 IU of vitamin D while ventilated in ICU – RCT June 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Vitamin D reduces sepsis
Intervention AND Youth (see also Infant-Child)
- 2,000 IU of vitamin D daily helped 80 percent of adolescents – Dec 2020
- Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014
- Migraines in youths with low Vitamin D wonderfully treated by Vitamin D – June 2019
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Winter youths need at least 1200 IU of vitamin D to maintain 20 nanograms – RCT 2016
- More calcium in bones in those teenage girls getting 2,000 IUs daily – RCT Jan 2016
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Vitamin D deficiency in adolescents, with 300,000 IU loading dose – Nov 2014
- Girls in India grew much faster when given Vitamin D, Ca, Zn, multi. – RCT Oct 2013
- Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010
Intervention AND Women (see also Pregnancy)
- Endometriosis treated by Vitamin D (50,000 IU bi-weekly) – RCT Jan 2021
- 500 mg of Magnesium for 8 weeks increased Vitamin D about 30 pcnt – RCT July 2020
- Dysmenorrhea substantially reduced by Ginger, just 1,000 IU Vitamin D also helped – RCT Nov 2019
- PMS again significantly reduced by 50,000 IU of vitamin D (This time, every two weeks) – RCT Oct 2019
- Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018
- Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT Feb 2018
- PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018
- Chinese women in tropics needed 50,000 IU of Vitamin D monthly to keep above 30 ng – RCT May 2017
- Only a select group of women will get a modest benefit from 800 IU of vitamin D – Jan 2017
- PMS reduced by half in girls who had low levels of vitamin D – RCT Dec 2015
- Bacterial vaginosis reduced 10 times by 2,000 IU of vitamin D – RCT June 2015
- Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015
- Post menopausal vaginal dryness treated with vitamin D vaginal suppositories – RCT March 2015
- Menstrual Pain reduced by vitamin D – RCT 2012, 2014, 2016
- PMS decreased when Vitamin D was added
Intervention AND Loading Dose
- Stoss (bolus, loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Half as many problems if take Vitamin D (300,000 IU) before thyroid surgery – RCT Jan 2021
- Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT Dec 2020
- 40 percent of successful Vitamin D studies use non-daily dosing - Nov 2020
- Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU – April 2020
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- Far more Vitamin D in breast milk from a 150,000 IU dose than from daily 5,000 IU – RCT May 2018
- Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Birth rates doubled with Vitamin D - 300,000 loading dose for men – RCT Nov 2017
- Promising Vitamin D Clinical Trials - 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016
- Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
- PMS reduced by half in girls who had low levels of vitamin D – RCT Dec 2015
- Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
- Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – 2015, 2016
- 200,000 IU restored levels in HIV children having low vitamin D - Nov 2014
- Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT March 2013
- 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
- 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT April 2015
- Clinical trials using a LOT of vitamin D intervention – Jan 2015
- Vitamin D deficiency in adolescents, with 300,000 IU loading dose – Nov 2014
- Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose – July 2014
- Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
- 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014
- Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013
- Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month – Oct 2012
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
- Grade A recommendations for vitamin D - May 2009
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Intervention - Vitamin D
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