Cardiovascular Disease Death Before Age 65 in 168 Countries Correlated Statistically with Biometrics, Socioeconomic Status, Tobacco, Gender, Exercise, Macronutrients, and Vitamin K
Cureus 8(8): e748. DOI 10.7759/cureus.748
David K. Cundiff 1 dkcundiff at whistleblowerdoctor.org , Paul S. Agutter 2
1. Internal Medicine, LA County + USC Medical Center (Retired) 2. Formerly with Theoretical Medicne and Biology Group, Formerly University of Edinburgh
Low Vitamin K2 is the most easily reduced risk factor
Vitamin D and Magnesium also PREVENT Cardiovascular diseases
All three may also TREAT cardivascular diseases
- Overview Cardiovascular and vitamin D
- Overview Vitamin K and Vitamin D
- Hypertension 1.7 times more likely if low Vitamin D AND K – Sept 2016
- Vitamin D Cofactors in a nutshell includes Magnesium Vitamin K2
- Vitamin D is not a cardiovascular fad like Vitamins C, E, Folic Acid, selenium, beta-caroteen, etc. – Circulation Nov 2013
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Major Heart attacks occur 40 percent more often if vitamin D lower than 7 ng – Feb 2013
- Smoking reduces vitamin D - many studies
Pages listed in BOTH the categories Vitamin K and Cardiovascular
- Vitamin K, cardiovascular health, and stroke - many studies
- Bone loss results in blood vessel plaque if low Vitamin K2, less bone loss if high K2– April 2021
- Cardiovascular Disease prevented by Vitamin K2-4 when enough is used – RCT review Sept 2020
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Vitamin K reduces calcification (reported yet again) – Feb 2019
- Vitamin K (across all dose sizes and types) decrease Vascular Stiffness – meta-analysis - Dec 2018
- Vitamin D and Vitamin K together fight CVD Part 1- Pizzorno
- Vitamin K, Cardiovascular and interactions with Vitamin D and Vitamin A – Pizzorno July 2018
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017
- Decalcify Aortic Valve – 3 year trial with 1 mg of Vitamin K and 5,000 IU of Vitamin D – 2021
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Athletes maximal cardiac output increased 12 percent with Vitamin K2 – RCT July 2017
- Fast blood flow 6.8 X more likely if high vitamin D AND high vitamin K – Aug 2017
- Low Vitamin K2 is as risky as smoking for heart disease - Oct 2016
- Cardiovascular death: 9 percent due to hypertension or air pollution, 7 percent: low Vitamin K2 or smoking – Oct 2016
- Decreased need for warfarin after Vitamin D levels optimized – RCT May 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- The health benefits of vitamin K – Oct 2015
- If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015
- Vitamin K2-7 decreases arterial stiffness (cleans arteries) – RCT Feb 2015
- Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Cholesterol, Vitamins D3 and K2, heart disease, sulfates, LDL, – Masterjohn Interview Jan 2013
- Soft Bones, Hard Arteries, Vitamin D, Vitamin K2 and antibiotics – Sept 2012
- Low Vitamin D and Vitamin K: brittle bones and hardened arteries – LEF Sept 2010
Pages listed in BOTH the categories Magnesium and Cardiovascular
- More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021
- Nitric oxide increased by UVA, Vitamin D, Magnesium, etc,
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies
- Signs of low Magnesium (heart problems in this case) – Jan 2018
- Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018
- Cardiometaboic problems decreased with increased Vitamin D, unless low Magnesium – Aug 2017
- Heart problems in obese increase if deficient in BOTH Vitamin D and Magnesium – Aug 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- More vitamin D makes for better health – dissertation based on Rotterdam studies – Oct 2015
- Atrial Fibrillation - remineralize your heart - Aug 2015
- Magnesium Suppresses Formation of Clogged Arteries - May 2014
- Off Topic: EDTA similar reduction in heart attack as Vitamin C, aspirin and Mg – RCT March 2013
- Death from Coronary Heart Disease related to low Magnesium intake – March 2013
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Hypothesis: Decreasing Magnesium and increasing CaMg ratio are increasing health problems – 2012 - 2013
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
Download the PDF from VitaminDWiki
Background
Nutrition researchers recently recognized that deficiency of vitamin K2 (menaquinone: MK-4- MK-13) is widespread and contributes to cardiovascular disease (CVD). The deficiency of vitamin K2 or vitamin K inhibition with warfarin leads to calcium deposition in the arterial blood vessels.
Methods
Using publicly available sources, we collected food commodity availability data and derived nutrient profiles including vitamin K2 for people from 168 countries. We also collected female and male cohort data on early death from CVD (ages 15-64 years), insufficient physical activity, tobacco, biometric CVD risk markers, socioeconomic risk factors for CVD, and gender. The outcome measures included (1) univariate correlations of early death from CVD with each risk factor, (2) a multiple regression-derived formula relating early death from CVD (dependent variable) to macronutrient profile, vitamin K1 and K2 and other risk factors (independent variables), (3) for each risk factor appearing in the multiple regression formula, the portion of CVD risk attributable to that factor, and (4) similar univariate and multivariate analyses of body mass index (BMI), fasting blood sugar (FBS) (simulated from diabetes prevalence), systolic blood pressure (SBP), and cholesterol/ HDL-C ratio (simulated from serum cholesterol) (dependent variables) and dietary and other risk factors (independent variables).
Results
Female and male cohorts in countries that have vitamin K2 < 5pg per 2000 kcal/day per capita (n = 70) had about 2.2 times the rate of early CVD deaths as people in countries with > 24 pg/day of vitamin K2 per 2000 kcal/day (n = 72). A multiple regression-derived formula relating early death from CVD to dietary nutrients and other risk factors accounted for about 50% of the variance between cohorts in early CVD death. The attributable risks of the variables in the CVD early death formula were:
- too much alcohol (0.38%),
- too little vitamin K2 (6.95%),
- tobacco (6.87%),
- high blood pressure (9.01%),
- air pollution (9.15%),
- early childhood death (3.64%),
- poverty (7.66%), and
- male gender (6.13%)
Conclusions from PDF
These multiple-regression equations relating CVD-associated outcomes to diet and other risk
factors should be confirmed with prospective studies on individuals.
Because of these findings, health regulatory agencies of countries should more inclusively
measure vitamin K2 levels (MK-4–MK-13) in foods and should designate levels for adequate
intakes (AIs) for vitamin K2. In wealthy countries, given the health concerns with excessive
meat, dairy, and eggs (e.g. obesity, type 2 diabetes, and cancer), vitamin K2 should be optimally
boosted from fermented plants containing long chain menaquinones rather than from animal
products. Likewise, for people in poor countries, increasing the intake of fermented foods such
as sauerkraut, miso, and natto would be the most cost-effective and healthful way to boost
vitamin K2 to adequate levels.