Overview Autism and vitamin D

• FACT: Studies have shown many associations of autism to low Vitamin D
• FACT: Clinical trial has prevented Autism with Vitamin D during pregnancy
• FACT: Clinical trial has treated autism in children
• RECOMMENDATION: Take extra vitamin D when pregnant
  There is a tiny risk in taking vitamin D during pregnancy, but a major risk in not doing so if you already have an autistic child

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Autism category in VitaminDWiki starts with:

Autism category has 133 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

• Most Autism Risk factors are associated with low vitamin D - March 2014
• Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
• Premature birth 2.5X more likely if mother had low vitamin D and was having twins – July 2013
• Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
• Having twins takes more vitamin D - May 2011

Autism treated by Vitamin D

• Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
• Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015

Autism reduced by vitamins before and during pregnancy

• Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
• Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
• Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
• Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016

Autism and Vitamin D Receptor (not enough Vit D to the tissues)

Autism - other risk factors

• Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
• Omega-3 probably can decrease Autism and ADHD – March 2019
• Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
• 20 X more Parkinson's and 100X more Autism with GMO soy in China
  • Note >100X increase in Autism while having GMO soy in the US

Vaccines increase the risk

• Does a vaccine increase the risk of Autism – March 2019
• Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
• Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
• Off topic: CDC deleted a 3X increase in black male autism due to vaccination – whistle blowing Aug 2014

Dr. Cannell on Autism and Vitamin D

• Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
• Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
• Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
• Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
• Autism treated by Vitamin D: Dr. Cannell - video June 2013
  • includes his list of 27 reasons to associate Vitamin D with Autism in 2013

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US explosion of Autism

chart is adapted from from http://autisminnb.blogspot.com/2011/01/autism-speaks-cdc-autism-prevalence.html
Autism cases in U.S. jump to 1 in 45 Nov 2015 - based on 2014 data
In 2014, it was 75 % boys, 25 % girls.
Autism – 1 in 40 children in the US (as of 2016) – Nov 2018
CDC update: 1 in 88 as of 2008 Reported March 2012
This is a 78 % increase in (2003-2008) for ALL children
110% increase for Hispanics, and 91% increase for black children (2003-2008) (dark skin strongly points to vitamin D)
CDC PDF of 2008 study which was finally published in 2012 is attached to the bottom of this page
Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016 JAMA 2018
Leveling out? 1.46% (1 in 68) based on survey of parents - has child been diagnosed with Autism

1 child in 68 CDC March 2014
An increase of about 30% from 2008 to 2010, which is also a 120% increase in decade since 2000/2002

Autism prevalence

Recent Autism items by Dr. Cannell of the Vitamin D Council

• Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
• Autism Overview updated Nov 2015
• Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
  50 IU of vitamin D / pound, with a goal of 80 ng/ml. Also, vitamin K2 3 mg/lb, best results before age 8
• Dr. Cannell on Autism – Spring 2013 videos - also mentions nice results of accidentally getting 10X too much vitamin D
• Autism treated by Vitamin D: Dr. Cannell - video June 2013 which includes reasons why Dr. Cannell believes Autism is related to Vitamin D (summarized by VitaminDWiki)

1. Both have strong inheritance features – Vitamin D about 60%
2. Both have gotten substantially worse in last 30 years
3. Vitamin D is known to be involved in brain development
4. All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
5. When giving vitamin D to cure children of rickets “mental dullness” decreases as well
6. Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
7. Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
8. Both associated with weak bones
9. Both worse around the age of weaning
10. Autism is more common in rich families – more likely to apply sun screen and stay indoors
11. Autism increases with drugs which lower levels of vitamin D
12. Seizures are common with Autism - Vitamin D has been shown to reduce seizures
13. Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
14. Both worse with latitude
15. Both vary with Ultraviolet light
16. Both vary with time of year (more birth of autistics in March in Northern hemisphere)
17. 2X more urban autism – less UVB in urban environments
18. Both worse with pollution
19. Both worse with increased clouds and rain
20. Both worse with closely spaced pregnancies
21. Autistics have abnormal immune response – similar to that of vitamin D deficiency
22. Low levels of vitamin D in mother animals reduces brain function in offspring
23. Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
24. Autistic children get less vitamin D in their blood for the same amount of sun exposure
25. The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
26. Both worse in African Americans (A-A 2-3 increased autism rate)
27. Both worse in Dark-skinned immigrants in Europe

•    Note: All articles in Autism category 133 items

Study out of China finds correlation between vitamin D status and autism severity Vitamin D Council Oct 2013
Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. - Oct 2013

Autism and Vitamin D - by John Cannell, MD Life Extension Jan 2014

Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015

• Animal study finds that suggests vitamin D may help prevent and treat autistic symptoms Vitamin D Council Feb 2016
  ". . . "if you want your children to be free of autism, we recommend both mom and dad supplement with 5,000 IU/day of vitamin D for at least 3 months before conception (this dose will also improve both male and female fertility). Then, the pregnant woman should remain on 5,000 IU/day, and perhaps 10,000 IU/day, which is the No Observed Adverse Effects Level (NOAEL) level for vitamin D intake throughout her pregnancy."
  "After the child is born, he or she should supplement with at least 1,000 IU/25 pounds of body weight per day. When the child reaches 125 pounds, he or she should take 5,000 IU/day. If the child shows any signs or symptoms of autism, the dose should be increased to 2,000 IU/per day/per 25 pounds of body weight."

Vitamin D Council Autism Infographic April 2016

See also in VitaminDwiki

• Autism category listing has 133 items along with related searches
• Autism 1.75X more likely if BOTH maternal and infant vitamin D levels were low – Nov 2019
• Autistic irritability reduced by Vitamin D plus Omega-3 – RCT March 2019
• Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis Jan 2019
• Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
• Autism 3X more likely after closely spaced pregnancy vs 3 years apart– Jan 2011
• Many reasons why vitamin D deficiency has become epidemic the same period of time that Autism has increased
• Early lack of vitamin D may trigger autism – Clinical Review April 2012
• 2X more poor language skills associated with low vitamin D during pregnancy – Feb 2012
• Less able to switch attention (an autism test) if mother had low vitamin D – Oct 2012
• Autism and schizophrenia strongly associated in families in Sweden July 2012
  • Example: Schizophrenia increases risk of Autism 2.9X (both are strongly associated with low vitamin D)
• Serotonin regulated by Vitamin D – part 1 autism – Feb 2014
• Autism is one of many health problems that has increased by 2X or more in a decade
• Same inflammation in the brain in half of the autistics, but different causes – May 2011

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See also Autism and Vitamin D on the web

• An Immune Disorder at the Root of Autism - New York Times Aug 2012
  immune dysregulation in the womb. Lists many viral and other problems during pregnancy which increase the probability of autistic child by 2X to 5X
  Moises Velasquez-Manoff is the author of “An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases.”
• Annual cost of autism has more than tripled - $126 billion US MedExpress March 2012
  3X increase since 2006. Costs were based on 0.5% of the population having ASD, however, CDC now reports 0.9% of the population has ASD
• Disease Database has lots of links to Autism
• PubMed Autism and "Vitamin D" 104 studies as of Dec 2016
  • 2X to 4X more children with Autism in Dutch cities which have lots of IT jobs - perhaps those kids to not get out in the sunshine as much
  • Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism Patrick 2014
  • Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children Oct 2016
  • Gestational vitamin D deficiency and autism-related traits: the Generation R Study. Nov 2016
  •    300 IU vitamin D3/kg/day, improved significantly
• Epidemiology - July 2011
  Reduced chance of having an autistic child by 40% by having pre-natal vitamins (most have just 400 IU of vitamin D, some have 800 IU)
  For certain gene types of the mother, the risk reduction due to taking pre-natal vitamins was 2.6X, 4.5X, and 7.2X
• New York Times July 2011 report on a new study of autistic twins
  Autism was due to shared environmental factors 58 % of the time.
• Long interesting blog post on Rickets, Vitamin D deficiency and Autism Feb 2012
• Etiopathogenesis of autism spectrum disorders: Fitting the pieces of the puzzle together Medical Hypothesis, July 2013
  We suggest that ASD are disorders of the immune system that occur in a very early phase of embryonic development.
  In a background of genetic predisposition and environmental predisposition (probably vitamin D deficiency), an infection (notably a viral infection) could trigger , , ,
• Vitamin D Deficiency During Pregnancy Raises Your Child’s Risk for Autism Mercola Dec 2016
  Includes Feb 2016 Interview with Dr.Patrick on Autism - both video and transcript
• New Study Confirms That Mercury Is Linked to Autism GreenMedInfo] Dec 2016
  The higher the mercry level the higher the autism. This DOES NOT prove causation. It could be that Autism ==> higher Mercery level.
• Mercury and Autism Relationship Confirmed in Longitudinal Study July 2017
  Study in: Science of The Total Environment Dec 2017; lots of blood tests
  If mercury level doubled at 2 time points then 31% increase risk of mild to moderate” deficits of social behavior related to autism
• CDC: report in March 2012 of a 2008 study 1 in 88 children in the U.S. in 2008 were diagnosed with an autism spectrum disorder
  a 23 % increase in the last two years and 78 % in (2003-2008) for all children
  110% increase for Hispanics, and 91% increase for black children (2003-2008) (this strongly points to vitamin D)
  Chart of ASD intelligence in 2008 study by CDC - varies a lot around the nation

• Autism on TedTalk March 2014
  good background, nothing about vitamin D, the following chart shows the 200-400 genes associated with different forms of autism

• Solving the Autism Puzzle Jan 2015 MIT Tech Review
  Nothing about vitamin D nor any way to prevent/treat Autism
  300 potential genes, 27 give a heightened risk of autism. Autistics with the same gene have similar symptoms.
  Every child born has roughly 60 new changes in their DNA sequence, and [one in] every 50 children born have at least one large rearrangement.
• Broccoli Sprout Extract (Sulforaphane) reduces symptoms of Autism RCT Aug 2015 (nothing about vitamin D)
  sulforaphane increases Vitamin D gene expression 2010
  Off-topic: Sulfur is very important to health Started on VitaminDWiki Dec 2016
• The Parents Who Jumpstarted Autism Research in California Oct 2016
  Funding many studies to prevent Autism, Nothing about vitamin D - which can prevent and treat
• Toddlers with Autism do not Avoid Eye Contact Scientific American] Dec 2016
  • Excellent study - they do not actively avoid eye contact, but it does not engage them - nothing about vitamin D

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Is it Time to Give Up on a Single Diagnostic Label for Autism? Scientific American May 2018

+"That was the ruling by the editors of the authoritative Diagnostic and Statistical Manual in 2013, but it remains controversial" +"All autistic individuals share core features, including social and communication difficulties, unusually narrow interests, a strong need for repetition and, often, sensory issues. Yet these core features vary enormously in how they are manifested, and in how disabling they are." +"There are huge disparities in many areas, such as language development or IQ, and in the presence or absence of co-occurring medical conditions and disabilities"

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HYPOTHESIS Vaccine ==> increased Autism

The Clear Legal Basis that Vaccines Cause Autism Green Med Info Sept 2018
Lengthy abstract of book How to End the Autism Epidemic Amazon published Sept 2018,
   #1 Best Seller in Pediatics Sept 19, 2018

• The Vaccine Act has a 3-year statute of limitation and virtually all Autisitic behaviour is not detected until after the 3 year limitation
• The one case in which Autism did start within the 3-year time limit was conceded by the govt (and the evidence was sealed), but the 5,500 other Autism claims were thrown out

Table Of Contents

• Vitamin D, Immune Activation and Autism Oct 2016
  Vitamin D blocks the bad effects of the Vaccine
• 10X reactions to flu vaccine when vitamin D deficient
• Vaccinated children had more chronic diseases - Sept 2018

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Around the world

Denmark

Autism and air pollution (no mention of Vitamin D) June 2013

PDF is attached at the bottom of this page

Clinical Review of Autism and Vitamin D 2012 - excellent

CLICK HERE if registered (free) for VitaminDWiki

ADHD strongly associated with Magnesium deficiency

Minerals imbalances influence learning disorders Natural Health 365
84% of kids with ADHD had significantly lower levels of iron compared to only 18% of control group

Autism is associated with lack of pruning in the brain - Aug 2014

Pruning Process May Go Awry in Brains of Children With Autism NY Times
the word vitamin does not occur once in the study which is attached at the bottom of this page

However, a Oct 2011 study associated Autism with TOO MUCH pruning -full text online
Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders.

Perhaps many Females are autistic - but they have very different symptoms than males

• Why It’s So Difficult to Diagnose Autism in Girls Slate Oct 2015
  "Some researchers theorize that girls are better than boys at camouflaging their symptoms, particularly during highly structured interactions such as clinic visits. For instance, a colleague of mine described girls with autism as “caricatures” in social interactions. These girls may be motivated to interact, but their behaviors seem exaggerated."
• The Invisible Women With Autism Atlantic Mag Oct 2015
  Similar article to Slate - very interesting
  Wonder if the perceived ratio of male/female will decrease in the future
• Vitamin D and Autism Spectrum Disorder: A Literature Review - 2016, 35 pages
   Download the PDF from VitaminDWiki

Hypothesis: Autism risk is related to gut bacteria

• Autism's Microbiome Atlantic Nov 2015
• Autism associated with low gut flora (due to antibiotics) – Mercola Oct 2014

Autistic Children slept longer with 2 - 5 mg of Melatonin - Nov 2017

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder
Slept 32 minutes longer than the placebo group. Nothing about Vitamin D
No comparison to non-autistic children

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Autism appears to be somewhat treated by Omega-3, wonder if it might prevent as well

• Autism Research Shows Benefit of Omega-3 Fatty Acids March 2017
  23 references include the following
  "Omega-3 fatty acids in the management of autism spectrum disorders" 2015
  “Role of polyunsaturated fatty acids in the management of Egyptian children with autism.” 2008
  . “A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder.” 2011
• Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: a meta-analysis of randomized controlled trials Oct 2017
   Download the PDF from VitaminDWiki

Items in both categories Autism and Omega-3 are listed here:

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Autism not treated by Gluten-free diet

Summary of Randomized Clinical trials spanning 10 year Examine.com April 2018

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Half of Autistic children have sleep problems such as insomnia

Autism and Sleep - What Parents Need to Know - Nov 2019

• 65% have shorter REM sleep, and many autistic children have sleep apnea
• Bright light in the morning seems to help - similar to helping people with Seaonal Affective Disorder

It appears that Autistics supplemented with Vitamin D sleep better
Items in both categories Autism and Sleep are listed here:

Short url = http://is.gd/DAutism