Rett syndrome associated with low vitamin D, treated by Omega-3

---

Omega-3 greatly helped RETT children - RCT Jan 2012

Partial rescue of Rett syndrome by x-3 polyunsaturated fatty acids (PUFAs) oil


 Download the PDF from VitaminDWiki

Study was cited 83 times by April 2021

---

Vitamin D deficiency in Serbian patients with Rett syndrome

The Journal of Clinical Endocrinology & Metabolism October 8, 2013 jc.2013-2627
Adrijan Sarajlija1, Milena Djuric 2,3, Darija Kisic Tepavcevic 3,4,; Sanja Grkovic 5 and Maja Djordjevic1,2
1Department of Metabolism and Clinical Genetics, Mother and Child Health Institute of Serbia, Belgrade;
2Department of Neurology, Mother and Child Health Institute of Serbia, Belgrade;
3Belgrade University School of Medicine, Serbia;
4Institute of Epidemiology, Belgrade, Serbia;
5Metabolic Laboratory, Mother and Child Health Institute of Serbia, Belgrade
Address all correspondence and requests for reprints to: Adrijan SARAJLIJA, e-mail: adrijans2004 at yahoo.com, Radoja Dakica Street 6–8, 11070 Novi Beograd, Serbia, phone: +381113108276, fax: +381113108276.

INTRODUCTION: Rett syndrome (RTT) is a severe neurodevelopmental disorder. Bone manifestations of RTT include osteopenia and fractures. Studies addressing serum vitamin D levels in RTT patients are scarce.

GOALS: 1. To determine prevalence of vitamin D deficiency in RTT patients, 2. To compare serum vitamin D levels between patients with RTT and other neurological diseases, 3. To explore correlation between demographic and clinical characteristics of RTT patients and vitamin D levels.

METHODS: Demographic and clinical characteristics included age, BMI z-score, mutation status, Clinical Severity Score, presence of epilepsy, number of antiepileptic drugs (AEDs), history of fractures, scoliosis and ambulation ability. Laboratory parameters included serum 25(OH)D, PTH, calcium and alkaline phosphatase.

RESULTS: The study included 35 RTT patients and 35 age-matched females with other neurological diseases. The median serum 25(OH)D in RTT group was 26.25 nmol/L, with values below 75 nmol/L in all participants. Severe deficiency (<25 nmol/L) was detected in 17/35 (48.6%) patients. Median 25(OH)D concentration was significantly lower in RTT patients than in controls. The risk for fracture by 12 years of age in RTT patients was 35.3%. Inverse correlation of 25(OH)D level to age and PTH level was detected. Patients receiving antiepileptic polytherapy had 3.3 times greater chance for severe vitamin D deficiency than patients with monotherapy.

CONCLUSION: Prevalence of vitamin D deficiency in RTT patients is higher than in patients with other neurological diseases.
High risk for vitamin D deficiency should be accounted for in the strategy of antiepileptic treatment in RTT, especially when polytherapy is considered.

---

49% had <10 ng/ml of vitamin D
3.3X more likely to have < 10 ng/ml if taking multiple antiepileptic drugs
Alternate hypothesis: Severe Ritt ==> polytherapy &l low vitamin D
Do vitamin D levels become low only AFTER seizures start (age 3)? (see chart below)

---

Autism category in VitaminDWiki

Start with

Autism category has 149 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

• Most Autism Risk factors are associated with low vitamin D - March 2014
• Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
• Premature birth 2.5X more likely if mother had low vitamin D and was having twins – July 2013
• Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
• Having twins takes more vitamin D - May 2011

Autism treated by Vitamin D

• Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
• Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015

Autism reduced by vitamins before and during pregnancy

• Low maternal Vitamin D results in larger portion of brain associated with autism – Jan 2020
• Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
• Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
• Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
• Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
• Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016

Autism and Vitamin D Receptor (not enough Vit D to the tissues)
This list is automatically updated

Autism - other risk factors

• Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
• Omega-3 probably can decrease Autism and ADHD – March 2019
• Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
• 20 X more Parkinson's and 100X more Autism with GMO soy in China
  • Note >100X increase in Autism while having GMO soy in the US

Autism and Virus/Vaccines
This list is automatically updated

Dr. Cannell on Autism and Vitamin D in VitaminDWiki

• Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
• Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
• Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
• Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
• Autism treated by Vitamin D: Dr. Cannell - video June 2013
  • includes his list of 27 reasons to associate Vitamin D with Autism in 2013

Autism and Omega-3
This list is automatically updated

---

See also VitaminDWiki

• Epilepsy seizures reduced by 40 percent after vitamin D levels normalized – April 2012
• Epilepsy and deficiency of vitamin D and-or Magnesium – Feb 2013
• Children with epilepsy advised to take vitamin D – July 2013
• Overview Autism and vitamin D
• Learning Disabilities, anti-epileptic drugs, and subsequent vitamin D deficiency - Oct 2014

See also web

• https://www.rettsyndrome.org/
• Vitamin D and Rett Syndrome Reverserett.org. Dec 2020
• WikiPedia Rare: 1 in 10,000 girls
  • The signs of this disorder are most easily confused with those of Angelman syndrome, cerebral palsy and autism.
• Fish Oil & Rett Syndrome – Everything I know Jan 2013
  Starts with a study (attached at the bottom of this page) 6 months 10 girls with omega-3 oils had improvements in:
  Growth (body), Motor skills/independent sitting, Walking ability, Purposeful hand use. Non-verbal communication, Breathing irregularities
  No improvements were reported in: Age of onset of regression. Head growth, Scoliosis, Autonomic systems, Onset of stereotypies (e.g. hand movements). Epilepsy/seizure activity

Some images from the web

Title change made April 2021 caused the visitor count to reset.
There have actually been 10281 visitors to this page since it was originally made