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Autistic children have lower levels of Iron, Vitamin D, Magnesium, etc – Oct 2017

Iron and vitamin D levels among autism spectrum disorders children

Ann Afr Med, 2017 Vol 16, Issue : 4, age : 186-191, online 16-Oct-2017, DOI: 10.4103/aam.aam_17_17

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Abdulbari Bener1, Azhar O Khattab2, Dinesh Bhugra3, Georg F Hoffmann4

  • 1 Department of Biostatistics and Medical Informatics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, England, UK
  • 2 Department of Pediatrics, Rumailah and Hamad General Hospital, Hamad Medical Corporation; Department of Pediatrics, Weill Cornell Medical College, Ar-Rayyan, Qatar
  • 3 Institute of Psychiatry, Section of Cultural Psychiatry, King's College London, London, England, UK
  • 4 Department of Pediatrics, University of Heidelberg, Baden-Wurttemberg, Germany

Aim: The aim of this study was to investigate iron deficiency anemia and Vitamin D deficiency among autism children and to assess the importance of risk factors (determinants).

Subjects and Methods: This was a case–control study conducted among children suffering from autism at the Hamad Medical Corporation in Qatar. A total of 308 cases and equal number of controls were enrolled. The Autism Diagnostic Observation Schedule-Generic was the instrument used for diagnosis of Autism.

Results: The mean age (±standard deviation, in years) for autistic versus control children was 5.39 ± 1.66 versus 5.62 ± 1.81, respectively. The mean value of serum iron levels in autistic children was severely reduced and significantly lower than in control children (74.13 ± 21.61 μg/dL with a median 74 in autistic children 87.59 ± 23.36 μg/dL in controls) (P = 0.003). Similarly, the study revealed that Vitamin D deficiency was considerably more common among autistic children (18.79 ± 8.35 ng/mL) as compared to healthy children (22.18 ± 9.00 ng/mL) (P = 0.004).
Finally, mean values of

  • hemoglobin,
  • ferritin,
  • magnesium;
  • potassium,
  • calcium;
  • phosphorous;
  • glucose,
  • alkaline phosphate,
  • hematocrit,
  • white blood cell, and
  • mean corpuscular volume

were all statistically significantly higher (better?) in healthy control children as compared to autistic children (P < 0.001).
Multivariate logistic regression analysis revealed that serum iron deficiency, serum calcium levels, serum Vitamin D levels; ferritin, reduced physical activity; child order, body mass index percentiles, and parental consanguinity can all be considered strong predictors and major factors associated with autism spectrum disorders.

Conclusion: This study suggests that deficiency of iron and Vitamin D as well as anemia were more common in autistic compared to control children.

Created by admin. Last Modification: Saturday May 20, 2023 21:22:32 GMT-0000 by admin. (Version 4)

Attached files

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8573 Autism T3.jpg admin 21 Oct, 2017 42.61 Kb 5130
8572 Autism T2.jpg admin 21 Oct, 2017 67.91 Kb 4708
8571 Austic children low Iron, Vit d, Mg,etc.pdf admin 21 Oct, 2017 165.59 Kb 895