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Low maternal Vitamin D results in larger portion of brain associated with autism – Jan 2020

A Prospective Population-Based Study of Gestational Vitamin D Status and Brain Morphology in Preadolescents

Neuroimage, , 116514 2020 Jan 2, DOI: 10.1016/j.neuroimage.2020.116514
Runyu Zou 1, Hanan El Marroun 2, John J McGrath 3, Ryan L Muetzel 1, Manon Hillegers 1, Tonya White 4, Henning Tiemeier 5


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Increased Putamen Volume in Adults with Autism Spectrum Disorder
Front Hum Neurosci. 2014; 8: 957.Nov 2014 . doi: 10.3389/fnhum.2014.00957 - Free PDF

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Low vitamin D level during pregnancy has been associated with adverse neurodevelopmental outcomes such as autism spectrum disorders (ASD) in children. However, the underlying neurobiological mechanism remains largely unknown. This study investigated the association between gestational 25-hydroxyvitamin D [25(OH)D] concentration and brain morphology in 2597 children at the age of 10 years in the population-based Generation R Study. We studied both 25(OH)D in maternal venous blood in mid-gestation and in umbilical cord blood at delivery, in relation to brain volumetric measures and surface-based cortical metrics including cortical thickness, surface area, and gyrification using linear regression. We found exposure to higher maternal 25(OH)D concentrations in mid-gestation was associated with a larger cerebellar volume in children (b = 0.02, 95%CI 0.001 to 0.04), however this association did not remain after correction for multiple comparisons. In addition, children exposed to persistently deficient (i.e., <25 nmol/L) 25(OH)D concentration from mid-gestation to delivery showed less cerebral gray matter and white matter volumes, as well as smaller surface area and less gyrification at 10 years than those with persistently sufficient (i.e., ≥50 nmol/L) 25(OH)D concentration. These results suggest temporal relationships between gestational vitamin D concentration and brain morphological development in children.

Created by admin. Last Modification: Tuesday January 7, 2020 13:22:26 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
13286 Autistic Brain size and vitamin D.jpg admin 07 Jan, 2020 38.26 Kb 427
13285 Brain D pregnancy.pdf admin 07 Jan, 2020 1.19 Mb 438