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Rett syndrome associated with low vitamin D, treated by Omega-3


Omega-3 greatly helped RETT children - RCT Jan 2012

Partial rescue of Rett syndrome by x-3 polyunsaturated fatty acids (PUFAs) oil
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 Download the PDF from VitaminDWiki

Study was cited 83 times by April 2021


Vitamin D deficiency in Serbian patients with Rett syndrome

The Journal of Clinical Endocrinology & Metabolism October 8, 2013 jc.2013-2627
Adrijan Sarajlija1, Milena Djuric 2,3, Darija Kisic Tepavcevic 3,4,; Sanja Grkovic 5 and Maja Djordjevic1,2
1Department of Metabolism and Clinical Genetics, Mother and Child Health Institute of Serbia, Belgrade;
2Department of Neurology, Mother and Child Health Institute of Serbia, Belgrade;
3Belgrade University School of Medicine, Serbia;
4Institute of Epidemiology, Belgrade, Serbia;
5Metabolic Laboratory, Mother and Child Health Institute of Serbia, Belgrade
Address all correspondence and requests for reprints to: Adrijan SARAJLIJA, e-mail: adrijans2004 at yahoo.com, Radoja Dakica Street 6–8, 11070 Novi Beograd, Serbia, phone: +381113108276, fax: +381113108276.

INTRODUCTION: Rett syndrome (RTT) is a severe neurodevelopmental disorder. Bone manifestations of RTT include osteopenia and fractures. Studies addressing serum vitamin D levels in RTT patients are scarce.

GOALS: 1. To determine prevalence of vitamin D deficiency in RTT patients, 2. To compare serum vitamin D levels between patients with RTT and other neurological diseases, 3. To explore correlation between demographic and clinical characteristics of RTT patients and vitamin D levels.

METHODS: Demographic and clinical characteristics included age, BMI z-score, mutation status, Clinical Severity Score, presence of epilepsy, number of antiepileptic drugs (AEDs), history of fractures, scoliosis and ambulation ability. Laboratory parameters included serum 25(OH)D, PTH, calcium and alkaline phosphatase.

RESULTS: The study included 35 RTT patients and 35 age-matched females with other neurological diseases. The median serum 25(OH)D in RTT group was 26.25 nmol/L, with values below 75 nmol/L in all participants. Severe deficiency (<25 nmol/L) was detected in 17/35 (48.6%) patients. Median 25(OH)D concentration was significantly lower in RTT patients than in controls. The risk for fracture by 12 years of age in RTT patients was 35.3%. Inverse correlation of 25(OH)D level to age and PTH level was detected. Patients receiving antiepileptic polytherapy had 3.3 times greater chance for severe vitamin D deficiency than patients with monotherapy.

CONCLUSION: Prevalence of vitamin D deficiency in RTT patients is higher than in patients with other neurological diseases.
High risk for vitamin D deficiency should be accounted for in the strategy of antiepileptic treatment in RTT, especially when polytherapy is considered.


49% had <10 ng/ml of vitamin D
3.3X more likely to have < 10 ng/ml if taking multiple antiepileptic drugs
Alternate hypothesis: Severe Ritt ==> polytherapy &l low vitamin D

Do vitamin D levels become low only AFTER seizures start (age 3)? (see chart below)


Autism category in VitaminDWiki

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Autism category has 136 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

Autism treated by Vitamin D

Autism reduced by vitamins before and during pregnancy

Autism and Vitamin D Receptor (not enough Vit D to the tissues)

Autism - other risk factors

Vaccines increase the risk

Dr. Cannell on Autism and Vitamin D

Autism and Omega-3


See also VitaminDWiki

See also web

  • https://www.rettsyndrome.org/
  • Vitamin D and Rett Syndrome Reverserett.org. Dec 2020
  • WikiPedia Rare: 1 in 10,000 girls
    • The signs of this disorder are most easily confused with those of Angelman syndrome, cerebral palsy and autism.
  • Fish Oil & Rett Syndrome – Everything I know Jan 2013
    Starts with a study (attached at the bottom of this page) 6 months 10 girls with omega-3 oils had improvements in:
    Growth (body), Motor skills/independent sitting, Walking ability, Purposeful hand use. Non-verbal communication, Breathing irregularities
    No improvements were reported in: Age of onset of regression. Head growth, Scoliosis, Autonomic systems, Onset of stereotypies (e.g. hand movements). Epilepsy/seizure activity

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Created by admin. Last Modification: Monday April 26, 2021 01:48:14 GMT-0000 by admin. (Version 21)

Attached files

ID Name Comment Uploaded Size Downloads
15507 Omega-3 table.jpg admin 26 Apr, 2021 01:18 59.16 Kb 89
15506 RETT Omega-3.jpg admin 26 Apr, 2021 01:17 21.22 Kb 109
3115 Rett vs years.jpg admin 12 Oct, 2013 14:00 45.70 Kb 1680
3114 Rett vs time.jpg admin 12 Oct, 2013 14:00 32.33 Kb 1573
3113 Rett diagram.jpg admin 12 Oct, 2013 13:59 28.86 Kb 1710
3112 Rett chart.jpg admin 12 Oct, 2013 13:59 43.44 Kb 8255
3111 Rett fish oil.pdf PDF 2013 admin 12 Oct, 2013 13:57 390.71 Kb 751
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