Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children.
Nutr Neurosci. 2015 Apr 15. [Epub ahead of print]
Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G, Abdel-Reheim MK, Othman HA, El-Houfey AA, Hashem EA, Abd El-Aziz NH, Abd El-Baseer KA, Ahmed AE, Ali AM.
*Corresponding author: khaled.ali at med.au.edu.eg
57% had < 20 ng of vitamin D
30% had 20-30 ng of vitamin D
Supplemented for 3 months
300 IU/kg/day (not to exceed 5000 IU/day)
80% had significant improved outcome
Autism category in VitaminDWiki starts withAutism category has
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
- Premature birth 2.5X more likely if mother had low vitamin D and was having twins – July 2013
- Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
- Having twins takes more vitamin D - May 2011
Autism treated by Vitamin D
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
Autism reduced by vitamins before and during pregnancy
- Low maternal Vitamin D results in larger portion of brain associated with autism – Jan 2020
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
Autism and Vitamin D Receptor (not enough Vit D to the tissues)
Autism - other risk factors
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- 20 X more Parkinson's and 100X more Autism with GMO soy in China
- Note >100X increase in Autism while having GMO soy in the US
Autism and Virus/Vaccines
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- Does a vaccine increase the risk of Autism – March 2019
- Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
- Vaccinated children had more chronic diseases - Sept 2018
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
Dr. Cannell on Autism and Vitamin D in VitaminDWiki
- Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
- Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
- includes his list of 27 reasons to associate Vitamin D with Autism in 2013
Autism and Omega-3
- Many autistic children are getting some Vitamin D, Omega-3, probiotics, etc. – Aug 2019
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism treated in one person by Omega-3 plus Vitamin D – Dec 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Autism risks include chemicals, deficiency of vitamin D, Omega-3 – mini-review April 2016
- Serotonin regulated by Vitamin D – part 1 autism – Feb 2014
- Rett syndrome associated with low vitamin D, treated by Omega-3
See also web
- Lack of effect of vitamin D3 supplementation in autism: a 20-week, placebo-controlled RCT June 2017
They used only 2,000 IU. Successful trials have found up to 5,000 IU is needed
Objectives Autism spectrum disorder (ASD) is a developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and non-verbal communication, and stereotyped patterns of interests and activities. Vitamin-D deficiency was previously reported in autistic children. However, the data on the relationship between vitamin D deficiency and the severity of autism are limited.
Methods We performed a case-controlled cross-sectional analysis conducted on 122 ASD children, to assess their vitamin D status compared to controls and the relationship between vitamin D deficiency and the severity of autism. We also conducted an open trial of vitamin D supplementation in ASD children.
Results Fifty-seven percent of the patients in the present study had vitamin D deficiency, and 30% had vitamin D insufficiency. The mean 25-OHD levels in patients with severe autism were significantly lower than those in patients with mild/moderate autism. Serum 25-OHD levels had significant negative correlations with Childhood Autism Rating Scale (CARS) scores. Of the ASD group, 106 patients with low-serum 25-OHD levels (<30 ng/ml) participated in the open label trial. They received vitamin D3 (300 IU/kg/day not to exceed 5000 IU/day) for 3 months. Eighty-three subjects completed 3 months of daily vitamin D treatment. Collectively, 80.72% (67/83) of subjects who received vitamin D3 treatment had significantly improved outcome, which was mainly in the sections of the CARS and aberrant behavior checklist subscales that measure behavior, stereotypy, eye contact, and attention span.
Conclusion Vitamin D is inexpensive, readily available and safe. It may have beneficial effects in ASD subjects, especially when the final serum level is more than 40 ng/ml. Trial registration number UMIN-CTR Study Design: trial Number: R000016846.
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Vitamin D deficiency correlates with severity of Autism and shows improvement with supplementation
Autism spectrum disorder (ASD) is a developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and non-verbal communication, and stereotyped patterns of interests and activities. Vitamin D deficiency has been previously reported in autistic children. However, the data on the relationship between Vitamin D deficiency and the severity of autism are limited.
In this study the researchers performed a case-controlled cross-sectional analysis on 122 ASD children, to assess their Vitamin D status compared to controls and the relationship between the degree of Vitamin D deficiency and the severity of autism.
They then conducted an open trial of Vitamin D supplementation in ASD children.
Fifty-seven percent of the patients in the study had Vitamin D deficiency, and 30% had Vitamin D insufficiency. The Vitamin D levels in patients with severe autism were significantly lower than those in patients with mild/moderate autism. Vitamin D levels had significant negative correlations with Childhood Autism Rating Scale (CARS) scores.
106 patients with low serum Vitamin D levels (<30 ng/ml) then participated in an open label trial of Vitamin D supplementation.
Patients were given 300 IU/kg/day (not to exceed 5000 IU/day) for 3 months.
Eighty-three subjects completed 3 months of daily vitamin D treatment.
80.72% (67/83) of subjects who received Vitamin D3 treatment had significantly improved outcome, which was mainly in the sections of the Childhood Autism Rating Scale and aberrant behavior checklist subscales that measure behavior, stereotypye, eye contact, and attention span. Of the 16 parameters measured, 10 showed highly statistically significant improvements (see table below)
|Parameter||P Value |
(* highly statistically significant)
|Relating to people||<0.001*|
|Adaption to change||0.004*|
|Taste, smell, touch||0.1|
|Total CARS score||<.001*|
The authors concluded that as Vitamin D is inexpensive, readily available and safe.
It may have beneficial effects in ASD subjects, especially when the final serum level is more than 40 ng/ml.
It should be noted that these results were achieved after only three months of Vitamin D supplementation. In a condition that is often present at birth and lasts a lifetime, this is a highly significant finding and should be should be fully explored immediately.
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