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Sleep problems reduced by vitamin D - Autistics and controls – July 2016

Sleep disturbances and serum vitamin D levels in children with autism spectrum disorder

Int J Clin Exp Med 2016;9(7):14691-14697 www.iicem.com /ISSN:1940-5901/IJCEM0028304
Received March 15, 2016; Accepted June 8, 2016; Epub July 15, 2016; Published July 30, 2016
Serhat Guler1, Gozde Yesil2, Mine Ozdil3, Bari§ Ekici4, Hasan Onal5
1Department of Pediatric Neurology, Edirne State Hospital Edirne, Turkey; 2Department of Medical Genetics, Bezmialem Vakif University Medical School, Istanbul, Turkey; 3Department of Pediatrics, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey; 4Department of Pediatric Neurology, LIV Hospital, Istanbul, Turkey; 5Department of Pediatric Endocrinologic and Metabolic Diseases, Istanbul, Kanuni Sultan Suleyman Education and Research Hospital, Turkey

Vitamin D improved sleep of both Autistics and Controls


VitaminDWiki Summary

The study supplmented with Vitamin D2 for 3 months
Vitamin D2 given to BOTH Autistics and Controls who had <30 nanograms
Insufficient group got 5,000 IU daily
Deficient group got 50,000 IU weekly ( 7,000 IU average)

  • "The 25(OH)D levels did not improve in 11.7% of ASD patients and 6.7% of controls after the treatment"

Comment: Using D3 and higher doses would have resulted in even better sleep

See also VitaminDWiki

Sleep category listing has 97 items along with related searches Autism category listing has 155 items along with related searches

The items in both Autism and Sleep categories are listed here:

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Sleep problems are among the most prevalent comorbidities experienced by children with Autism Spectrum Disorder (ASD). There is a clinical and physiological basis for a link between 25(OH)D levels and sleep disorders. In this study we aimed to investigate the frequency of sleep disorders in ASD patients and its association with 25(OH) D levels, and whether or not these frequencies changed after 25(OH)D treatment. This prospective study included 60 consecutive patients diagnosed with ASD and matched healthy controls between the ages of 4 and 10. Patients then underwent 25(OH)D replacement therapy according to their deficiency levels. Pre- and post-therapy values were compared. Sleep disturbance was detected in 78.3% of ASD patients (n = 60) and 33.3% of the control group (n = 60). When we compared the pretreatment scores of sleep disturbance between ASD and control groups (n = 60), there were significant differences in bedtime resistance, sleep anxiety, parasomnias, daytime sleepiness, sleep duration, sleep-onset delay, night wakings subscales, and total scale score (p < 0.05); however there were no significant differences with respect to the sleep-disordered breathing subscales (p > 0.05). In ASD patients, there was a significant negative correlation between serum 25(OH)D levels and the night wakings subscale (r = -0.301, p = 0.019). In control patients, there was a significant negative correlation between serum 25(OH)D levels and daytime sleepiness subscales (r = -0.269, p = 0.038). The results indicate that it may be suitable to use 25(OH)D replacement therapy in ASD patients and healthy individuals with sleep disturbances.

Attached files

ID Name Comment Uploaded Size Downloads
7061 Autism sleep and vitamin D.pdf admin 10 Sep, 2016 259.19 Kb 949
7060 Autism sleep T5.jpg admin 10 Sep, 2016 109.59 Kb 1118