Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis
Molecular Psychiatry (2019) https://doi.org/10.1038/s41380-019-0357-9
Azahara M García-Serna & Eva Morales
ADHD
- Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
- ADHD decreased by 11% for each 10 ng increase in vitamin D in early pregnancy – April 2015
- Increased Vitamin D not help nearly as much in mid or late pregnancy
- ADHD and Vitamin D category listing has
44 items along with related searches Items in both categories ADHD and Meta-analysis are listed here:
- Incidence Autism and ADHD reduced 18 percent per 10 ng of Vitamin D during pregnancy – meta-analysis Jan 2022
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Autism risk increased 30 percent by Cesareans (both low vitamin D) – meta-analysis Sept 2019
- Attention-Deficit Hyperactivity Disorder helped by Vitamin D, need more data – meta-analysis July 2019
- Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis Jan 2019
- ADHD associated with low vitamin D in all 8 trials – meta-analysis Oct 2018
- ADHD in children 2.6 X more likely if low vitamin D – meta-analysis Feb 2018
Autism
- Overview Autism and vitamin D
- Autism category listing has
148 items along with related searches Items in both categories Autism and Intervention are listed here:
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Autistics have half of the response to Vitamin D (perhaps poor genes) – RCT Oct 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
Items in both categories Autism and Meta-analysis are listed here:
- Incidence Autism and ADHD reduced 18 percent per 10 ng of Vitamin D during pregnancy – meta-analysis Jan 2022
- Autism associated with low Vitamin D (again) – Meta-Analysis Jan 2021
- Autism 2X more likely if poor Vitamin D Receptor (yet again) – meta-analysis Jan 2020
- Autism risk increased 30 percent by Cesareans (both low vitamin D) – meta-analysis Sept 2019
- Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis Jan 2019
- Autism risk factors – many are associated with low vitamin D – meta-meta-analysis March 2017
- Autism is associated with low vitamin D – meta-analysis Oct 2015
Autism treated by Vitamin D: Dr. Cannell - video June 2013 includes many reasons why he believes Autism is related to Vitamin D
- Both have strong inheritance features – Vitamin D about 60%
- Both have gotten substantially worse in last 30 years
- Vitamin D is known to be involved in brain development
- All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
- When giving vitamin D to cure children of rickets “mental dullness” decreases as well
- Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
- Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
- Both associated with weak bones
- Both worse around the age of weaning
- Autism is more common in rich families – more likely to apply sun screen and stay indoors
- Autism increases with drugs which lower levels of vitamin D
- Seizures are common with Autism - Vitamin D has been shown to reduce seizures
- Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
- Both worse with latitude
- Both vary with Ultraviolet light
- Both vary with time of year (more birth of autistics in March in Northern hemisphere)
- 2X more urban autism – less UVB in urban environments
- Both worse with pollution
- Both worse with increased clouds and rain
- Both worse with closely spaced pregnancies
- Autistics have abnormal immune response – similar to that of vitamin D deficiency
- Low levels of vitamin D in mother animals reduces brain function in offspring
- Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
- Autistic children get less vitamin D in their blood for the same amount of sun exposure
- The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
- Both worse in African Americans (A-A 2-3 increased autism rate)
- Both worse in Dark-skinned immigrants in Europe
- Note: All articles in Autism category
148 items Download the PDF from Sci-Hub via VitaminDWiki
ADHD
AUTISM
Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn blood at birth and neurodevelopmental outcomes, including cognition, psychomotor performance, language development, behavioral difficulties, attention deficit and hyperactivity disorder (ADHD), and autistic traits. PubMed, Web of Science and SCOPUS databases were systematically searched for epidemiologic studies published through May 2018 using keywords. Random-effects meta-analyses were conducted. Of 260 identified articles, 25 were included in the present review. Comparing the highest vs. the lowest category of prenatal 25(OH)D levels, the pooled beta coefficients were 0.95 (95% CI −0.03, 1.93; p = 0.05) for cognition, and 0.88 (95% CI −0.18, 1.93; p = 0.10) for psychomotor development.
The pooled relative risk for- ADHD was 0.72 (95% CI, 0.59, 0.89; p = 0.002), and the pooled odds ratio for
- autism-related traits was 0.42 (95% CI, 0.25, 0.71; p = 0.001).
There was little evidence for protective effects of high prenatal 25(OH)D for language development and behavior difficulties. This meta-analysis provides supporting evidence that increased prenatal exposure to 25(OH)D levels is associated with improved cognitive development and reduced risk of ADHD and autism-related traits later in life. Associations represent a potentially high public health burden given the current prevalence of vitamin D deficiency and insufficiency among childbearing aging and pregnant women.
Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis Jan 2019Printer Friendly Follow this page for updates2947 visitors, last modified 29 Jan, 2019, This page is in the following categories (# of items in each category)