Toggle Health Problems and D

Autistic severity oscillated when giving or not giving vitamin D – need at least 40 ng – April 2018

Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children: Three cases report.

Nutr Neurosci. 2018 Apr 8:1-4. doi: 10.1080/1028415X.2018.1458421. [Epub ahead of print]
Jia F1,2,3, Shan L1, Wang B1, Li H1, Feng J1, Xu Z4, Saad K1,5.
1 Dept of Developmental and Behavioral Pediatrics , The First Hospital of Jilin Univ. , Changchun 130021 , People's Republic of China.
2 Institute of Pediatrics of First Hospital of Jilin University , Changchun 130021 , People's Republic of China.
3 Neurological Research Center of First Hospital of Jilin University , Changchun 130021 , People's Republic of China.
4 Department of Psychiatry , University Medical Center Utrecht , Netherlands.
5 Pediatric Department, Faculty of Medicine , Assiut University , Assiut , Egypt.

 Download the PDF from Sci-Hub via VitaminDWiki


Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by complicated interactions between genetic and environmental factors. Clinical trials, including case reports, case-control studies, and a double-blinded randomized clinical study, have suggested that high-dose vitamin D3 regimens may ameliorate the core symptoms of ASD. Vitamin D3 supplementation was effective in about three-quarters of children with ASD. To further investigate the relationship between vitamin D and ASD symptoms in vitamin D-responsive autistic children, changes in symptoms were assessed in three children with ASD who were given vitamin D3 supplementation followed by a long interruption.

The core symptoms of ASD were remarkably improved during the vitamin D3 supplementation period when serum 25-hydroxyvitamin D [25(OH)]D levels reached over 40.0 ng/mL.

However, symptoms reappeared after the supplementation was stopped, when serum 25(OH)D levels fell below 30.0 ng/mL but were again improved with re-administration of vitamin D3 after the interruption, when serum 25(OH)D levels exceeded 40.0 ng/mL.
Overall, these results showed that the core symptoms of ASD fluctuated in severity with changes in serum 25(OH)D levels in children, indicating that maintaining a responsive 25(OH)D level is important for treating ASD. Maintaining a serum 25(OH)D level between 40.0 and 100.0 ng/ml may be optimal for producing therapeutic effects in vitamin D-responsive individuals with ASD.

PMID: 29629638 DOI: 10.1080/1028415X.2018.1458421

Created by admin. Last Modification: Tuesday April 10, 2018 15:47:52 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
9677 Autism oscillate.jpg admin 10 Apr, 2018 60.54 Kb 648
9676 Autistic severity varied with Vitamin D.pdf admin 10 Apr, 2018 429.66 Kb 576