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Autistic child 2.4 X more likely if less than 10 ng of vitamin D during 2nd trimester – April 2017

BJPsych Open. 2017 Apr 10;3(2):85-90. doi: 10.1192/bjpo.bp.116.004077. eCollection 2017.

Gestational vitamin D deficiency and autism spectrum disorder.

VitaminDWiki Summary

4334 singleton pregnancies of white European women

ASDNot ASD
Deficient 0.24% 0.16%
Insufficient 0.21% 0.26%
Sufficient 0.55% 0.58%
Total 62 3895
See also VitaminDWiki

The items in both Autism and Pregnancy are listed here:


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Vinkhuyzen AAE1, Eyles DW2, Burne THJ2, Blanken LME3, Kruithof CJ4, Verhulst F5, White T5, Jaddoe VW6, Tiemeier H7, McGrath JJ8.
1, PhD, Queensland Brain Institute, The University of Queensland, St Lucia, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
2, PhD, Queensland Brain Institute, The University of Queensland, St Lucia, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia.
3, MD, MSc, The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
4, MSc, The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
5, MD, PhD, Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
6, MD, PhD, The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.
7, MD, PhD, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
8, MD, PhD, Queensland Brain Institute, The University of Queensland, St Lucia, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia.

BACKGROUND:
There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.

AIMS:
To determine the association between gestational vitamin D status and ASD.

METHOD:
Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases).

RESULTS:
Individuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, P=0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only.

CONCLUSIONS:
Mid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency is readily preventable with safe, inexpensive and readily available supplementation, this risk factor warrants closer scrutiny.

PMID: 28446959 PMCID: PMC5385921 DOI: 10.1192/bjpo.bp.116.004077

Attached files

ID Name Comment Uploaded Size Downloads
7948 Gestational D and Autism.pdf PDF 2017 admin 28 Apr, 2017 22:09 205.70 Kb 138
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