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Autism associated with low vitamin D during pregnancy – Nov 2016

See also "Autism, Vitamin D and Early Brain Development" 2016

 Download the attached PDF from VitaminDWiki


Molecular Psychiatry advance online publication 29 November 2016; doi: 10.1038/mp.2016.213
A A E Vinkhuyzen1, D W Eyles1,2, T H J Burne1,2, L M E Blanken3,4, C J Kruithof3,5, F Verhulst4, V W Jaddoe3,5,6, H Tiemeier4,5 and J J McGrath1,2,7

See also VitaminDWiki

The TOP articles in Autism and Vitamin D are listed here:

Items in both categories Autism and Pregnancy are listed here:

Autism treated by Vitamin D: Dr. Cannell - video June 2013
includes many reasons why he believes Autism is related to Vitamin D

  1. Both have strong inheritance features – Vitamin D about 60%
  2. Both have gotten substantially worse in last 30 years
  3. Vitamin D is known to be involved in brain development
  4. All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
  5. When giving vitamin D to cure children of rickets “mental dullness” decreases as well
  6. Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
  7. Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
  8. Both associated with weak bones
  9. Both worse around the age of weaning
  10. Autism is more common in rich families – more likely to apply sun screen and stay indoors
  11. Autism increases with drugs which lower levels of vitamin D
  12. Seizures are common with Autism - Vitamin D has been shown to reduce seizures
  13. Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
  14. Both worse with latitude
  15. Both vary with Ultraviolet light
  16. Both vary with time of year (more birth of autistics in March in Northern hemisphere)
  17. 2X more urban autism – less UVB in urban environments
  18. Both worse with pollution
  19. Both worse with increased clouds and rain
  20. Both worse with closely spaced pregnancies
  21. Autistics have abnormal immune response – similar to that of vitamin D deficiency
  22. Low levels of vitamin D in mother animals reduces brain function in offspring
  23. Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
  24. Autistic children get less vitamin D in their blood for the same amount of sun exposure
  25. The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
  26. Both worse in African Americans (A-A 2-3 increased autism rate)
  27. Both worse in Dark-skinned immigrants in Europe

Social Responsiveness (SRS) of 22,000 Japanese school children - lower score is better
Image


 Download the PDF from VitaminDWiki

1Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia
2Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia
3The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
4Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
5Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
6Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
7National Centre for Register-Based Research, Aarhus University, Aarhus C, Denmark
Correspondence: Professor JJ McGrath, Queensland Brain Institute, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. E-mail: j.mcgrath at uq.edu.au
Image

There is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed in a continuous fashion, share risk factors with ASD, and thus can serve as informative phenotypes in population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency with altered brain development, this common exposure is a candidate modifiable risk factor for ASD and autism-related traits. The association between gestational vitamin D deficiency and a continuous measure of autism-related traits at ~6 years (Social Responsiveness Scale; SRS) was determined in a large population-based cohort of mothers and their children (n=4229). 25-hydroxyvitamin D (25OHD) was assessed from maternal mid-gestation sera and from neonatal sera (collected from cord blood). Vitamin D deficiency was defined as 25OHD concentrations less than 25 nmol l 1. Compared with the 25OHD sufficient group (25OHD>50 nmol l 1), those who were 25OHD deficient had significantly higher (more abnormal) SRS scores (mid-gestation n=2866, β=0.06, P<0.001; cord blood n=1712, β=0.03, P=0.01).
The findings persisted

  • (a) when we restricted the models to offspring with European ancestry,
  • (b) when we adjusted for sample structure using genetic data,
  • (c) when 25OHD was entered as a continuous measure in the models and
  • (d) when we corrected for the effect of season of blood sampling.

Gestational vitamin D deficiency was associated with autism-related traits in a large population-based sample. Because gestational vitamin D deficiency is readily preventable with safe, cheap and accessible supplements, this candidate risk factor warrants closer scrutiny.

Attached files

ID Name Comment Uploaded Size Downloads
8212 autism-vitamin-d-and-early-brain-development.pdf PDF 2016 admin 26 Jul, 2017 09:14 317.02 Kb 58
7410 Pregnancy autism.jpg admin 29 Nov, 2016 13:41 67.33 Kb 342
7409 Gestational vitamin D deficiency, Autism.pdf admin 29 Nov, 2016 13:30 218.50 Kb 221
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