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Increased risk of ADHD (28 pct.) and Autism (58 pct.) if low vitamin D during pregnancy – meta-analysis Jan 2019

Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis

Molecular Psychiatry (2019) https://doi.org/10.1038/s41380-019-0357-9
Azahara M García-Serna & Eva Morales

VitaminDWiki

ADHD

Items in both categories ADHD and Meta-analysis are listed here:


Autism

Items in both categories Autism and Intervention are listed here:

Items in both categories Autism and Meta-analysis are listed here:

Autism treated by Vitamin D: Dr. Cannell - video June 2013 includes many reasons why he believes Autism is related to Vitamin D

  1. Both have strong inheritance features – Vitamin D about 60%
  2. Both have gotten substantially worse in last 30 years
  3. Vitamin D is known to be involved in brain development
  4. All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
  5. When giving vitamin D to cure children of rickets “mental dullness” decreases as well
  6. Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
  7. Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
  8. Both associated with weak bones
  9. Both worse around the age of weaning
  10. Autism is more common in rich families – more likely to apply sun screen and stay indoors
  11. Autism increases with drugs which lower levels of vitamin D
  12. Seizures are common with Autism - Vitamin D has been shown to reduce seizures
  13. Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
  14. Both worse with latitude
  15. Both vary with Ultraviolet light
  16. Both vary with time of year (more birth of autistics in March in Northern hemisphere)
  17. 2X more urban autism – less UVB in urban environments
  18. Both worse with pollution
  19. Both worse with increased clouds and rain
  20. Both worse with closely spaced pregnancies
  21. Autistics have abnormal immune response – similar to that of vitamin D deficiency
  22. Low levels of vitamin D in mother animals reduces brain function in offspring
  23. Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
  24. Autistic children get less vitamin D in their blood for the same amount of sun exposure
  25. The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
  26. Both worse in African Americans (A-A 2-3 increased autism rate)
  27. Both worse in Dark-skinned immigrants in Europe

 Download the PDF from Sci-Hub via VitaminDWiki

ADHD

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AUTISM

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Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn blood at birth and neurodevelopmental outcomes, including cognition, psychomotor performance, language development, behavioral difficulties, attention deficit and hyperactivity disorder (ADHD), and autistic traits. PubMed, Web of Science and SCOPUS databases were systematically searched for epidemiologic studies published through May 2018 using keywords. Random-effects meta-analyses were conducted. Of 260 identified articles, 25 were included in the present review. Comparing the highest vs. the lowest category of prenatal 25(OH)D levels, the pooled beta coefficients were 0.95 (95% CI −0.03, 1.93; p = 0.05) for cognition, and 0.88 (95% CI −0.18, 1.93; p = 0.10) for psychomotor development.
The pooled relative risk for

  • ADHD was 0.72 (95% CI, 0.59, 0.89; p = 0.002), and the pooled odds ratio for
  • autism-related traits was 0.42 (95% CI, 0.25, 0.71; p = 0.001).

There was little evidence for protective effects of high prenatal 25(OH)D for language development and behavior difficulties. This meta-analysis provides supporting evidence that increased prenatal exposure to 25(OH)D levels is associated with improved cognitive development and reduced risk of ADHD and autism-related traits later in life. Associations represent a potentially high public health burden given the current prevalence of vitamin D deficiency and insufficiency among childbearing aging and pregnant women.

Created by admin. Last Modification: Tuesday January 29, 2019 18:00:01 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
11291 Autism.jpg admin 29 Jan, 2019 17:03 28.29 Kb 69
11290 ADHD.jpg admin 29 Jan, 2019 17:02 30.15 Kb 70
11289 ADHD Autism meta sci-hub.pdf PDF 2019 admin 29 Jan, 2019 17:02 1.02 Mb 56
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