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Autism virtually non-existent if vitamin D levels greater than 44 ng while pregnant - Dec 2023

High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10 - A randomized clinical trial

The American Journal of Clinical Nutrition https://doi.org/10.1016/j.ajcnut.2023.12.002
Kristina Aagaard MD 1, Jens Richardt Møllegaard Jepsen MSc PhD 2 3, Astrid Sevelsted MSc PhD 1, David Horner MSc MD 1, Rebecca Vinding MD PhD 1, Julie Bøjstrup Rosenberg MD 1 3, Nicklas Brustad MD PhD 1, Anders Eliasen MSc PhD 1 4, Parisa Mohammadzadeh MD 1 3, Nilofar Følsgaard MD PhD 1, María Hernández-Lorca MSc PhD 1, Birgitte Fagerlund 2 3 5, Birte Y. Glenthøj MD DMSc 3 6, Morten Arendt Rasmussen MSc PhD 1 7, Niels Bilenberg MD PhD 8 9, Jakob Stokholm MD PhD 1 7, Klaus Bønnelykke MD PhD 1 6, Bjørn H. Ebdrup MD PhD 3 6 1, Bo Chawes MD PhD DMSc 1 6 1

Note: They tried supplementing pregnant women with only 2,800 IU of vitamin D - no success
Pregnancies with > 44 ng/mL of vitamin D resulted in virtually no autistic children
Vitamin D deficiency in pregnancy may increase risk of autism and attention deficit hyperactivity disorder (ADHD).

To estimate the effect of vitamin D3 supplementation in pregnancy on risk of autism and ADHD.

This randomized clinical trial was part of the COpenhagen Prospective Study on Neuro-PSYCHiatric Development (COPSYCH) project nested within the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising a population-based sample of 700 healthy mother-child pairs enrolled at week 24 of pregnancy. Maternal 25-hydroxy-vitamin D (25(OH)D) was measured at inclusion and 623 mothers were randomized 1:1 to either high-dose (2800 IU/d) or standard-dose (400 IU/d) vitamin D3 until 1 week postpartum (315 received high-dose, 308 standard dose). At age 10, diagnoses and symptom load of autism and ADHD, respectively, were established using the Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL).

591 children completed the psychopathological evaluation at age 10, sixteen children (2.7%) were diagnosed with autism and 65 (11.0%) with ADHD. Hereof, 496 children participated in the vitamin D3 trial (246 received high-dose, 250 standard dose). Of these, twelve children (2.4%) were diagnosed with autism and 58 (11.7%) with ADHD. Higher maternal pre-intervention 25(OH)D levels were associated with a decreased risk of autism (OR per 10 nmol/L 0.76 (0.59,0.97), p=0.034)), lower autistic symptom load (β per 10 nmol/L -0.03 (-0.05,0.00), p=0.024), and decreased risk of ADHD diagnosis (OR per 10 nmol/L 0.88 (0.78,0.99), p=0.033). High-dose vitamin D3 supplementation was not associated with risk of autism or ADHD.

Higher maternal pre-intervention 25(OH)D was associated with a decreased risk of autism, lower autistic symptom load, and decreased risk of ADHD diagnosis, but high-dose vitamin D3 supplementation in pregnancy had no effect on risk of autism and ADHD.

Clipped from PDF: Previous study used 5,000 IU: Autism 20% ==> 5%
"In a prospective study from 2016, vitamin D supplementation in pregnancy among mothers of children with autism decreased the recurrence rate of autism in newborn siblings from previously reported 20% to 5%.(41) These mothers were prescribed 5000 IU vitamin D3 per day during pregnancy..."
Wonder why this study did not also use 5,000 IU

 Download the PDF from VitaminDWiki

Only a few studies >40 ng/mL with 2,000 IU of Vitamin D daily

Dose/response from 36 studies
Dose Response Dec 2015 (VDW# 7156)
solid line = mean response (50% above, 50% below)
Lower dashed line = 97.5% will have achieved the level
click here for details

VitaminDWiki – Autism category contains:

Autism category has 157 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

Autism treated by Vitamin D

Autism reduced by vitamins before and during pregnancy

Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated

Autism - other risk factors

6 Autism and Virus/Vaccines

Dr. Cannell on Autism and Vitamin D in VitaminDWiki

7 studies: Autism reduced by Omega-3

VitaminDWiki - ADHD and Vitamin D Deficiency

Attached files

ID Name Comment Uploaded Size Downloads
20475 Autism 44 ng.png admin 11 Dec, 2023 186.90 Kb 95
20474 Autim ADHD not reduced by 2,800 IU_CompressPdf.pdf admin 11 Dec, 2023 319.54 Kb 43