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Autism risk increased by 44% if there were pregnancy and labor complications (probably low vitamin D) – Kaiser Jan 2017

Association of Perinatal Risk Factors with Autism Spectrum Disorder.

Am J Perinatol. 2017 Feb;34(3):295-304. doi: 10.1055/s-0036-1597624. Epub 2017 Jan 31.


The PDF is hiding behind a $49 paywall.

  • Fact: Low Vitamin D During Pregnancy increases Autism Risk
  • Fact: Many pregnancy and labor complications are due to low vitamin D
  • Suspect that low vitamin D vitamin D in mother ==> complications ==> Autism

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Items in both of the categories of Pregnancy and Autism are listed here:

Getahun D1, Fassett MJ2, Peltier MR3, Wing DA4, Xiang AH1, Chiu V1, Jacobsen SJ1.
1Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
2Division of Maternal-Fetal Medicine, Department of Obstetrics-Gynecology, Kaiser Permanente Southern California, West Los Angeles, Los Angeles.
3Winthrop University Hospital Research Institute, Winthrop University Hospital, Mineola, New York.
4Department of Obstetrics-Gynecology, University of California, Irvine, California.

Objective To examine the association between exposures to perinatal factors and autism spectrum disorders (ASD).

Study Design A retrospective cohort study of ASD among children born in Kaiser Permanente Southern California hospitals between 1991 and 2009 (n = 594,638). Medical records were used to determine exposure to perinatal (antepartum and intrapartum) complications. ASD was diagnosed using DSM-IV criteria. Multivariable Cox regression was used to estimate hazard ratios (Hrs).

Result Children with ASD were more likely to be exposed to perinatal complications (HR = 1.15, 95% confidence interval [CI]: 1.09-1.21) than neurotypical children. Children exposed to antepartum (HR = 1.22, 95% CI: 1.10-1.36) and intrapartum (HR = 1.10, 95% CI: 1.04-1.17) complications were at increased risk of ASD. The risk was even greater when both antepartum and intrapartum conditions were present (HR = 1.44, 95% CI: 1.26-1.63).

Conclusion Exposure to antepartum or intrapartum complications increases the risk of ASD in the offspring. Therefore, pregnancy complications may help identify children who could benefit from early screening and intervention for this common neurodevelopmental condition.

PMID: 28099978 DOI: 10.1055/s-0036-1597624

Press Release from Kaiser for this study does mention Vitamin D

"In August 2016, a Kaiser Permanente study found that the risk of younger siblings developing an autism spectrum disorder is 14 times higher if an older sibling has ASD. And in 2015, a Kaiser Permanente study found that children whose mothers developed gestational diabetes by the 26th week of pregnancy were at increased risk of developing autism later in life."

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