Association of polymorphisms of vitamin D gene in children with asthma and allergic rhinitis - Hospital based study
Heliyon https://doi.org/10.1016/j.heliyon.2023.e23673
Narmada Ashok, Radha Saraswathy
Vitamin D gene polymorphisms are known to be associated with asthma and allergic rhinitis in children. However, the genetic association of the same in South Indian children with above condition is still unknown. The present study was designed with the objective to analyze the association of polymorphisms of vitamin D receptor gene (VDR) (rs797532, rs154410, rs2258470, rs731236) and transport gene of vitamin D (rs7041) in children with asthma and allergic rhinitis in South India. Children (1-18years) presenting with symptoms suggestive of asthma and allergic rhinitis to hospital based outpatient department, in Vellore, South India were recruited as cases and children presenting with minor illness without respiratory complaints were enrolled as controls during January 2018 to September 2021. Polymorphisms were genotyped using tetraarms PCR. Significant increase in levels of absolute eosinophil counts and serum IgE levels with decrease in vitamin D levels was seen among the cases. Significant association between levels of vitamin D and serum IgE was also observed.
Analysis of polymorphisms showed that, in comparison to homozygous major allele the odds of having heterozygous (OR0.55 (0.3, 0.99) and homozygous minor form (OR0.52 (0.28, 0.97) of rs7975232, homozygous minor (OR 0.51 (0.34, 0.76)) and alternate allele (OR 0.7 (0.53, 0.93)) of rs154410 and homozygous minor form (OR 0.57 (0.37, 0.88) of rs731236 was significantly lesser among the cases.
Genotypic model of rs154410 (p0.023) and allele form of rs7041 (p 0.041) were significantly associated with vitamin D levels however no association of gene blocks with cases was seen in haplotype analysis. There was an apparent gene pool difference noted in comparative analysis between Indian studies. The study is the first in south India to analyze levels of serum IgE, Vitamin D levels, association of VDR polymorphisms, and rs7041 in children with asthma.
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13+ VitaminDWiki pages having HAY FEVER or ALLERGIC RHINITIS in the title
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Items found: 14
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Hay fever decreases productivity, Vitamin D can help - many studies |
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08 Apr, 2024 |
Hay fever and autism 2X more likely if poor Vitamin D Receptor (children in India) - Jan 2024 |
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15 Mar, 2024 |
Allergic rhinitis sublingual therapy was 22X more successful if good level of Vitamin D – Feb 2023 |
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15 Mar, 2023 |
Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019 |
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02 Aug, 2019 |
Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019 |
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23 Jul, 2019 |
6X as many people with allergic rhinitis were severely vitamin D deficient – Jan 2012 |
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30 Jun, 2019 |
Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019 |
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05 Jun, 2019 |
Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018 |
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31 Jan, 2018 |
Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016 |
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23 Aug, 2016 |
Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015 |
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02 Nov, 2015 |
Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 |
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22 Oct, 2015 |
Allergic rhinitis associated with less vitamin D in men yet more in women – Jan 2014 |
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05 Jul, 2015 |
Allergic rhinitis 56 percent more likely if low vitamin D – Nov 2013 |
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23 Oct, 2013 |
Vitamin D supplements increased probability of allergic rhinitis by 66 percent - 2004 |
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23 Oct, 2013 |
9+ VitaminDWiki vitamin D Receptor pages have ASTHMA in the title
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Asthma and Vitamin D Receptor - many pages |
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04 Feb, 2025 |
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21 Dec, 2023 |
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04 Aug, 2021 |
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07 Nov, 2019 |
Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 |
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23 Oct, 2019 |
Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016 |
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12 Nov, 2016 |
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 |
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09 Sep, 2015 |
Strong Vitamin D deficiency associations in Asthma patients – Nov 2014 |
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18 Nov, 2014 |