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Autism and vitamin D: Cannell, Grant – March 2013

What is the role of vitamin D in autism?

Dermato-Endorcrinology January/February/March 2013 Volume 5, Issue 1
John J. Cannell, William B. Grant

A growing body of literature suggests that higher serum 25-hydroxyvitamin D [25(OH)D] concentrations, either in utero or in early life, may reduce the risk of autism. For example, an ecological study in the companion paper inversely correlated solar UV-B doses in the United States with prevalence of autism among those aged 6–17 y. That study proposed that vitamin D deficiency during pregnancy could account for this finding, although the findings are also consistent with childhood vitamin D deficiency contributing to the condition. Also, in a recent study, children with autism had lower serum 25(OH)D concentrations than did control subjects (19 vs. 33 ng/ml), despite parents of each group reporting the same amount of sun exposure. The same study found highly significant inverse correlations between 25(OH)D and autism rating scales and between 25(OH)D and levels of an antineuronal antibody. This finding indicates that higher serum 25(OH)D concentrations may reduce the symptoms of established autism. Because activated vitamin D, a secosteroid, upregulates DNA-repair genes, vitamin D deficiency during development may inhibit the repair of de novo DNA mutations in fetuses and infants and thus contribute to risk of autism. Vitamin D might also reduce the risk or severity of autism through its anti-inflammatory actions, antiautoimmune effects, increasing seizure threshold, increasing T-regulatory cells, protecting the mitochondria, and upregulating glutathione, which scavenges oxidative by-products and chelates (captures and excretes) heavy metals. Vitamin D deficiency during pregnancy and childhood is a widespread and growing epidemic.

PDF is attached at the bottom of this page

See also VitaminDWiki

  • Overview Autism and vitamin D - which has the following
    Autism Causes, Prevention and Treatment: Vitamin D Deficiency and the Explosive Rise of Autism Spectrum Disorder
    Book April 2015, 192 pages, $16 Dr. Cannell has also written a nice book on Vitamin D and Sports


  • Autism treated by Vitamin D: Dr. Cannell - video June 2013 which includes reasons why Dr. Cannell believes Autism is related to Vitamin D (summarized by VitaminDWiki)

    1. Both have strong inheritance features – Vitamin D about 60%
    2. Both have gotten substantially worse in last 30 years
    3. Vitamin D is known to be involved in brain development
    4. All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
    5. When giving vitamin D to cure children of rickets “mental dullness” decreases as well
    6. Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
    7. Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
    8. Both associated with weak bones
    9. Both worse around the age of weaning
    10. Autism is more common in rich families – more likely to apply sun screen and stay indoors
    11. Autism increases with drugs which lower levels of vitamin D
    12. Seizures are common with Autism - Vitamin D has been shown to reduce seizures
    13. Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
    14. Both worse with latitude
    15. Both vary with Ultraviolet light
    16. Both vary with time of year (more birth of autistics in March in Northern hemisphere)
    17. 2X more urban autism – less UVB in urban environments
    18. Both worse with pollution
    19. Both worse with increased clouds and rain
    20. Both worse with closely spaced pregnancies
    21. Autistics have abnormal immune response – similar to that of vitamin D deficiency
    22. Low levels of vitamin D in mother animals reduces brain function in offspring
    23. Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
    24. Autistic children get less vitamin D in their blood for the same amount of sun exposure
    25. The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
    26. Both worse in African Americans (A-A 2-3 increased autism rate)
    27. Both worse in Dark-skinned immigrants in Europe

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Attached files

ID Name Comment Uploaded Size Downloads
3238 Autism Cannell Grant.pdf PDF - 2013 admin 10 Nov, 2013 19:31 364.70 Kb 440
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