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The genetics of vitamin D – Oct 2018

Bone 126 (2019) 59-77

VitaminDWiki

The study appears to ignore many of the genes which reduce the amount of Vitamin D in the blood which gets to the tissues


CYP27B1 category listing contains the following

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
Blood Test Misses a lot (VDW 3439)


Additional information on the Genes in VitaminDWiki

Gene# of pages Location
CYP27A1449 (Sept 2019) Liver
CYP2R1 826 (Sept 2019)Liver & Tissue
CYP27B11430   (Sept 2019) Kidney & Tissue
CYP24A1 1280   (Sept 2019) excrete excess

Vitamin D Receptor is associated in over 40 autoimmune studies


Vitamin D Receptor and Cancers

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:


Vitamin D Binding Protein category listing has 138 items is mentioned in the study

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,


Vitamin D Binding Protein has a list of health problems

Increased
Risk
Health Problem
11 XPreeclampsia
6 XFood Allergy
5 XPTSD
4 X, 5XKidney Cancer
4 XPoor Response to Oral Vitamin D
3 XEar infection
2 X MS
2 X Colorectal Cancer
2 XProstate Cancer -in those with dark skins
1.3 XInfertility

 Download the PDF fromSci-Hub VitaminDWiki

Heritability

Image

Xia Jianga,b’*, Douglas P. Kiel' -'1-6, Peter Kraft3
a Program in Genetic Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Brookline, Boston 02115, USA
b Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Nobels vagen 13, Stockholm 17177, Sweden
c Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, United States
d Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States
e Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02142, United States

Vitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, cardiovascular conditions and more. However, the causal role of vitamin D beyond its importance for bone health remains unclear and is under much debate.
Twin and familial studies from past decades have demonstrated a nontrivial heritability of circulating vitamin D concentrations.
Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/ DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D. A recent whole genome sequencing (WGS) study, combined with deep imputation of genome-wide genotyping, has identified a low-frequency synonymous coding variant at CYP2R1. Information on these genetic variants can be used as tools for downstream analysis such as Mendelian randomization. Here, we review the genetic determinants of circulating vitamin D levels by focusing on new findings from GWAS and WGS, as well as results from Mendelian randomization analyses conducted so far for vitamin D with various traits and diseases. The amount of variation in vitamin D explained by genetics is still small, and the putative causal relationship between vitamin D and other diseases remains to be demonstrated.

Created by admin. Last Modification: Saturday January 25, 2020 21:57:52 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13406 Heritability.jpg admin 25 Jan, 2020 21:44 87.50 Kb 59
13405 Genes and Vitamin D sci-hub.pdf PDF 2018 admin 25 Jan, 2020 21:44 813.68 Kb 25
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