Bone 126 (2019) 59-77
The study appears to ignore many of the genes which reduce the amount of Vitamin D in the blood which gets to the tissues
CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, Rickets
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
| Gene | # of pages | Location
|
| CYP27A1 | 449 (Sept 2019) | Liver
|
| *CYP2R1 | 826 (Sept 2019) | Liver & Tissue
|
| CYP27B1 | 1430 (Sept 2019) | Kidney & Tissue
|
| CYP24A1 | 28 in title - May 2022] | excrete excess |
Vitamin D Receptor and Cancers
89+ Vitamin D Receptor pages with CANCER in the title
This list is automatically updated
Items found: 93
|
Title |
|
Modified |
|
Soft tissue sarcoma (Cancer) is assocated with poor Vitamin D Receptors and low levels of Vitamin D |
|
25 Apr, 2025 |
|
Soft tissue sarcoma (Cancer) is assocated with poor Vitamin D Receptors and low levels of Vitamin D |
|
25 Apr, 2025 |
|
Vitexin activates the Vitamin D Receptor to fight Colon Cancer - Jan 2025 |
|
15 Jan, 2025 |
|
Breast Cancer prevented in 5 ways via the Vitamin D Receptor – Oct 2024 |
|
02 Nov, 2024 |
|
Poor Vitamin D Receptor does not increase the risk of Breast Cancer (but the opposite is true) – umbrella meta-analysis Sept 2024 |
|
06 Sep, 2024 |
|
Pancreatic Cancer protects itself deactivating HNF4A (which can be reactivated by the Vitamin D Receptor) – April 2024 |
|
29 Jul, 2024 |
|
Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024 |
|
29 Jun, 2024 |
|
Vitamin D Receptor (Cancers OR Viruses) - many studies |
|
02 Mar, 2024 |
|
Oral Cancer and Vitamin D and VDR - several studies |
|
11 Feb, 2024 |
|
Breast Cancer risk reduced if consume butyrate - Dec 2023 |
|
23 Jan, 2024 |
|
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023 |
|
13 Jan, 2024 |
|
Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023 |
|
27 May, 2023 |
|
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 |
|
06 Dec, 2022 |
|
Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022 |
|
31 Oct, 2022 |
|
2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012 |
|
16 Sep, 2022 |
|
Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022 |
|
15 Aug, 2022 |
|
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 |
|
27 Jul, 2022 |
|
Breast Cancer, Vitamin D, and genes – Welsh Nov 2021 |
|
09 Feb, 2022 |
|
How cancer is fought by Vitamin D (Ovarian this time) - Feb 2020 |
|
01 Nov, 2021 |
|
Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021 |
|
25 Oct, 2021 |
|
Cancers and Vitamin D Receptors, including change with race – Feb 2021 |
|
24 Oct, 2021 |
|
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies |
|
18 Oct, 2021 |
|
After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021 |
|
20 Aug, 2021 |
|
Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021 |
|
10 Jul, 2021 |
|
Oral Cancers - increased risk if low vitamin D or poor vitamin D genes |
|
22 Jan, 2021 |
|
Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021 |
|
15 Jan, 2021 |
|
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020 |
|
09 Dec, 2020 |
|
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 |
|
02 May, 2020 |
|
Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020 |
|
22 Jan, 2020 |
|
8 ways that Cancer might be prevented by Vitamin D - June 2019 |
|
26 Dec, 2019 |
|
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 |
|
14 Dec, 2019 |
|
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 |
|
15 Nov, 2019 |
|
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 |
|
09 Nov, 2019 |
|
Cancer is leading cause of death - Vitamin D and Receptor activators help |
|
09 Nov, 2019 |
|
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 |
|
06 Nov, 2019 |
|
Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019 |
|
19 Oct, 2019 |
|
Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019 |
|
23 Aug, 2019 |
|
Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019 |
|
29 Jul, 2019 |
|
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies |
|
14 Jun, 2019 |
|
Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019 |
|
14 Jun, 2019 |
|
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 |
|
13 Jun, 2019 |
|
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 |
|
04 Jun, 2019 |
|
Effects of Resveratrol against Lung Cancer in mice – Nov 2017 |
|
28 Apr, 2019 |
|
The Role of Resveratrol in Cancer Therapy – Dec 2017 |
|
27 Apr, 2019 |
|
Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019 |
|
11 Apr, 2019 |
|
A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019 |
|
26 Mar, 2019 |
|
Breast Cancer and Vitamin D review – March 2018 |
|
17 Mar, 2019 |
|
Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018 |
|
15 Mar, 2019 |
|
Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019 |
|
11 Feb, 2019 |
|
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 |
|
09 Dec, 2018 |
|
Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018 |
|
10 Nov, 2018 |
|
Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018 |
|
01 Nov, 2018 |
|
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 |
|
03 Oct, 2018 |
|
Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018 |
|
15 Aug, 2018 |
|
Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018 |
|
08 Aug, 2018 |
|
Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018 |
|
07 Jul, 2018 |
|
Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018 |
|
16 Jun, 2018 |
|
Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018 |
|
28 Mar, 2018 |
|
Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018 |
|
17 Mar, 2018 |
|
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 |
|
14 Dec, 2017 |
|
Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017 |
|
19 Oct, 2017 |
|
Cancer and the Vitamin D Receptor, a primer – Sept 2017 |
|
01 Oct, 2017 |
|
Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017 |
|
26 Aug, 2017 |
|
Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017 |
|
19 Aug, 2017 |
|
Cancer risks and Vitamin D Receptors – association is unclear – 2017 |
|
19 Aug, 2017 |
|
Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016 |
|
09 Aug, 2017 |
|
Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017 |
|
02 Aug, 2017 |
|
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 |
|
27 Jul, 2017 |
|
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 |
|
25 Jul, 2017 |
|
Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015 |
|
15 Jun, 2017 |
|
Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015 |
|
17 Mar, 2017 |
|
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 |
|
06 Mar, 2017 |
|
2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017 |
|
04 Mar, 2017 |
|
Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 |
|
02 Mar, 2017 |
|
Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017 |
|
01 Mar, 2017 |
|
Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013 |
|
27 Feb, 2017 |
|
Vitamin D receptor may suppress skin cancer – Dec 2013 |
|
27 Jan, 2017 |
|
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 |
|
28 Dec, 2016 |
|
Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016 |
|
06 Dec, 2016 |
|
Vitamin D, Vitamin D Receptor and Cancer – Nov 2016 |
|
05 Dec, 2016 |
|
High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016 |
|
14 Nov, 2016 |
|
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 |
|
14 Nov, 2016 |
|
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 |
|
12 Nov, 2016 |
|
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 |
|
23 Sep, 2016 |
|
Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 |
|
17 Mar, 2016 |
|
Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 |
|
06 Jan, 2016 |
|
Pancreatic Cancer treatment by calcipotriol (a synthetic vitamin D) improves outcome by 57 percent – Sept 2014 |
|
13 Dec, 2015 |
|
Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 |
|
18 Oct, 2015 |
|
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 |
|
03 May, 2015 |
|
Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013 |
|
06 Jan, 2014 |
|
Genes breast cancer and vitamin D receptor - Sept 2010 |
|
08 Jul, 2013 |
|
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012 |
|
08 Jul, 2013 |
|
Vitamin D receptor in breasts and breast cancer vary with race – March 2013 |
|
08 Jul, 2013 |
Vitamin D Binding Protein category listing has 178 items is mentioned in the study
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
Vitamin D Binding Protein has a list of health problems
Download the PDF fromSci-Hub VitaminDWiki
Heritability
Xia Jianga,b’*, Douglas P. Kiel' -'1-6, Peter Kraft3
a Program in Genetic Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Brookline, Boston 02115, USA
b Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Nobels vagen 13, Stockholm 17177, Sweden
c Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, United States
d Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States
e Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02142, United States
Vitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, cardiovascular conditions and more. However, the causal role of vitamin D beyond its importance for bone health remains unclear and is under much debate.
Twin and familial studies from past decades have demonstrated a nontrivial heritability of circulating vitamin D concentrations.
Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/ DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D. A recent whole genome sequencing (WGS) study, combined with deep imputation of genome-wide genotyping, has identified a low-frequency synonymous coding variant at CYP2R1. Information on these genetic variants can be used as tools for downstream analysis such as Mendelian randomization. Here, we review the genetic determinants of circulating vitamin D levels by focusing on new findings from GWAS and WGS, as well as results from Mendelian randomization analyses conducted so far for vitamin D with various traits and diseases. The amount of variation in vitamin D explained by genetics is still small, and the putative causal relationship between vitamin D and other diseases remains to be demonstrated.