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Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019

Polymorphisms within vitamin D binding protein gene within a Preeclamptic South African population.

Hypertens Pregnancy. 2019 Sep 27:1-8. doi: 10.1080/10641955.2019.1667383


Items in all 3 categories Pregnancy, Hypertension, and Vitamin D Binding Protein:

Pregnancy and Vitamin D Binding Protein:

Items in Preeclampsia (categories Pregnancy & Hypertension):

Vitamin D Binding Protein category listing has 177 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,
Africa category listing has 28 items along with related searches

 Download the PDF from Sci-Hub via VitaminDWiki

Authors: Naidoo Y1, Moodley J2, Ramsuran V3, Naicker T4.

  • 1 Discipline of Optics and Imaging, Women's Health and HIV Research Group , Durban , South Africa.
  • 2 KZN Research Innovation and Sequencing Platform, University of KwaZulu-Natal , Durban , South Africa.
  • 3 KwaZulu-Natal Research and Innovation Sequencing Platform, University of KwaZulu-Natal Nelson R Mandela School of Medicine , Durban , South Africa.
  • 4 Department of Optics and Imaging, University of KwaZulu-Natal , Durban , South Africa.

Objectives: The vitamin D binding protein encoded by the GC gene contains two single nucleotide polymorphisms (rs4588 and rs7041) that have been associated with disease outcome, these include periodontitis coronary heart disease and hypertension. In pregnancy, these SNPs influence vitamin D metabolism that could result in hypertensive disorders such as PE. The etiology of PE, still remains elusive. The aim of this study was to evaluate the distribution of rs4588 and rs7041 within the GC gene among PE and normotensive pregnant women, residing in Durban, KwaZulu-Natal, South Africa.

Study design: Our study consisted of n = 600 participants (normotensive (n = 246, N); early onset PE (n = 167, EOPE); and late-onset PE (n = 246, LOPE)). We extracted DNA from whole blood and genotyped for rs4588 and rs7041 SNPs using the TaqMan assay.

Results: Regardless of HIV status, we observed the rs4588 (CC genotype) more frequently in PE (EOPE+LOPE) compared to the normotensive participants with an OD ratio of 0.74 (95% CI, 0.35-1.5; p < 0.001). We report a significant difference in the frequency of rs7041 (GT genotype) in the EOPE group compared to the normotensive group with an OD ratio of 11.48 (95% CI, 2.6-103.7; p < 0.001). The rs7041 GT genotype had a higher frequency in the EOPE compared to the LOPE group, with an OD ratio of 15.15 (95% CI, 2.3-639.2; p < 0.001).

Conclusion: This is the first study to describe the prevalence of SNPs of the rs4588 and rs7041 within the GC gene in women with PE within the high HIV endemic area of KZN, South Africa. Notably, a significant association of the rs7041 (TT genotype) and rs4588 (CC genotype) occurred at a higher frequency in PE compared to the normotensive cohort. Future studies will examine the functional effect of the GC region in relation to pregnancy and vitamin D deficiency.

Created by admin. Last Modification: Saturday October 19, 2019 02:33:06 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12696 Preeclampsia VDBP.jpg admin 29 Sep, 2019 180.16 Kb 657
12695 VDBP preeclampsia South Aftrica Sci-hub.pdf admin 29 Sep, 2019 511.91 Kb 529