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Vitamin D receptor in breasts and breast cancer vary with race – March 2013

Vitamin D Receptor Gene Polymorphisms and Prognosis of Breast Cancer among African-American and Hispanic Women

PLoS ONE 8(3): e57967. doi:10.1371/journal.pone.0057967
Dhruva K. Mishra, Yanyuan Wu, Marianna Sarkissyan, Suren Sarkissyan, Zujian Chen, Xiying Shang, May Ong, David Heber, H. Phillip Koeffler, Jaydutt V. Vadgama

Background: Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among African-Americans and Hispanics. This study examines whether VDR gene polymorphisms are associated with breast cancer in these cohorts.

Methods: Blood was collected from 232 breast cancer patients (Cases) and 349 non-cancer subjects (Controls).
Genotyping for four polymorphic variants of VDR (FokI, BsmI, TaqI and ApaI) was performed using the PCR-RFLP method.

Results: An increased association of the VDR-Fok1 f allele with breast cancer was observed in African-Americans (OR = 1.9, p = 0.07). Furthermore, the FbTA, FbtA and fbtA haplotypes were associated with breast cancer among African-Americans (p<0.05). Latinas were more likely to have the VDR-ApaI alleles (Aa or aa) (p = 0.008). The VDR-ApaI aa genotype was significantly associated with poorly-differentiated breast tumors (p = 0.04) in combined Cases. Kaplan-Meier survival analysis showed decreased 5-year disease-free-survival (DFS) in breast cancer patients who had the VDR-Fok1 FF genotype (p<0.05). The Cox regression with multivariate analysis revealed the independent predictor value of the VDR-FokI polymorphism for DFS. The other three variants of VDR (BsmI, TaqI and ApaI) were not associated with disease outcome.

Conclusions: VDR haplotypes are associated with breast cancer in African-Americans, but not in Hispanic/Latinas.
The VDR-FokI FF genotype is linked with poor prognosis in African-American women with breast cancer.

Received: November 5, 2012; Accepted: January 29, 2013; Published: March 12, 2013

Funding: This work was supported by National Institutes of Health(NIH)/NCI (Grant numbers U56CA101599-01; CA15083-25S3; U54CA14393); NIH/NIDDK (Grant number R25DK067015-01); Department of Defense (BCRP) (Grant number BC043180) – to JVV. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Far more women died of breast cancer with these altered genes

Image
Note: more graphs in the PDF

PDF is attached at the bottom of this page


Suspect that Caucasian women with these VDR genes would need more vitamin D in blood stream to prevent breast cancer.

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
2224 Fok!.jpg admin 20 Mar, 2013 03:08 27.73 Kb 1084
2223 Genes and breast cancer.pdf PDF admin 20 Mar, 2013 00:04 275.33 Kb 713
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