Neuroepidemiology. 2010 Oct 14;35(4):281-290.
Mohr SB, Gorham ED, Garland CF, Grant WB, Garland FC.
Department of Family and Preventive Medicine 0620, University of California San Diego, La Jolla, Calif., USA.
Brain Cancer - Males
Background: The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, modeled 25-hydroxyvitamin D [25(OH)D] levels and incidence rates of cancer of the brain.
Methods: Associations of latitude and UVB irradiance with age-standardized incidence rates of cancer of the brain were analyzed for 175 countries while controlling for proportion of population overweight, energy from animal sources, fish consumption, cigarette and alcohol consumption and per capita health expenditures, using multiple regression. Serum 25(OH)D levels were modeled for each country, and their association with brain cancer also was determined.
Results: The incidence rates of brain cancer were higher at higher latitudes (R(2) for males = 0.45, p ? 0.0001; R(2) for females = 0.35, p < 0.0001). After adjustment for potential confounders, UVB irradiance (p ? 0.0001) and modeled serum 25(OH)D were inversely associated with incidence rates.
Conclusions: Countries with low solar UVB irradiance and estimated mean serum 25(OH)D levels generally had higher age-standardized incidence rates of brain cancer. Since this was an ecological study, further research would be worthwhile on the association of prediagnostic serum 25(OH)D with incidence rate in studies of cohorts of individuals.
The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patients.
Biomed Res Int. 2013;2013:295791. doi: 10.1155/2013/295791. Epub 2013 Apr 17.
Toptaş B, Kafadar AM, Cacina C, Turan S, Yurdum LM, Yiğitbaşı N, Gökçe MO, Zeybek U, Yaylım I.
Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma.
Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP).
Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles.
Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.
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